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Biotech / Medical : Incyte (INCY) -- Ignore unavailable to you. Want to Upgrade?


To: Biomaven who wrote (2674)10/13/2011 11:41:22 AM
From: software salesperson  Read Replies (1) | Respond to of 3202
 
Peter,

Thanks for posting the news from the NEJM. FWIW, I also sold my holdings for these reasons:

(a) while I understand that the article referenced an older trial with a larger dose than the registrational Comfort trials, I don't understand how there can be such a discrepancy in long term use results between the NEJM-referenced trial and the Comfort 1 trial, about which management said in 5/11:

(iii) Comfort 1 patients remain on drug? - - vast majority; minimal dropout rate

(b) also, I don't see how the efficacy can be so different than what management described, especially since the dose was larger in the NEJM-referenced trial

(c) if approved, the market will be substantially smaller

(d) I don't see how the FDA can ignore this new info during their deliberations

sales



To: Biomaven who wrote (2674)10/13/2011 11:56:00 AM
From: Biotech Jim  Read Replies (1) | Respond to of 3202
 
I am completely out of my INCY holdings based in part on this rebound effect news.

It will be interesting for the PFE JAK inhibitor in the RA patient population whether there is a rebound of ACRs upon drug cessation, since this is the patient population that would appear to have the earliest readout.