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Biotech / Medical : VVUS: VIVUS INC. (NASDAQ) -- Ignore unavailable to you. Want to Upgrade?

To: BigKNY3 who wrote (2739)	11/20/1997 11:47:00 PM
From: DR. BOND	Read Replies (2) \| Respond to of 23519

Nice post BigKNY3...But quickly your answer to quesion 1 is somewhat misleading. Viagra has shown to be effective in ~81% of Psychogenic patients which do not make up 81% of the ED population. So this figure is FAR smaller than *81% in relative terms. However I do believe that Viagra will be a BLOCKBUSTER DRUG that will REVOLUTIONIZE the way men embrace ED therapy, and thus other more applicabe ED therapy's will benefit from this, mainly VVUS! "Wife is calling"<ggg> .........Take Care

To: BigKNY3 who wrote (2739)	11/21/1997 2:00:00 AM
From: Andrew H	Read Replies (1) \| Respond to of 23519

>>ED Cause % Responders ................ Placebo...Viagra Mixed .......... 27%.....74% Organic.......... 16%.....59% Psychogenic...... 30%.....81% Diabetes......... 12%.....48% Spinal Cord...... 0%.....75%<< Spinal cord figures are more than remarkable. They are unbelievable. Results as a whole are truly impressive. Is there a website where I can view these as part of a larger report? Thanks. Much appreciated. If these are accurate and respresentative, there is no doubt the PFE has a blockbuster on their hands. I agree the drug will help VVUS.

To: BigKNY3 who wrote (2739)	11/21/1997 10:15:00 AM
From: Cacaito	Read Replies (2) \| Respond to of 23519

Spinal Cord injuries are to be expected to response well to a vasodilator since the penis itself is normal, the central nervous sytem is impaired, but not the autonomic (sympathetic and parasympathetic systems )which is the reason of involuntary erections in normal subjects. In Spinal Cord injuries there is a big unbalance in this system, and when one of then is stimulated, in this case the parasympathetic side then there is a strong reaction to the stimuli. Muse will be almost 100% effective in this cases (theoretically). Of course, there is comunication between the CNS and the Autonomic system, one type of dysruption is the Psychogenic, but when the patient is sleeping without a need of any drugs the autonomic system during REM sleep will trigger an erection. The mixed group, the psychogenic and the spinal cord one are normal penis or very close to normal (mixed). This is why the results are practically the same among the three. Viagra could be a good co-therapy for the psychogenic ED not a bad niche. In the Spinal cord group Viagra is causing an erection, much better than the "enhanced" an erection now popular theory (in viagra favor). The Organic and Diabetes groups do have a decrease response to viagra, BUT the placebo responders in those groups are also significantly smaller, this could be explained (in viagra favor) to a pre-screen population (more organically affected) and the results are a partial indication of effectiveness (more data is needed to a definite conclusion, so is again believe Pfizer or not). Still, we do not have available the age distribution of the groups, or other drug use for other problems. "initially it was thought that they were all impotent due to none physical reasons" Who? Initially the hype was that viagra was 80 something in ED (no groups) and now we are seing a little bit of data. Also, You mentioned that you have not here about patients or investigators complaining of side effects. Of course, neither patients , nor investigators have published anything. The Medical Tribune article about the presentation in Spain gives a range of 40% to 59%. Again, no age distribution and no specification of the organic problem, neither of concomitant drug use for other problems. Not even 100 patients in that trial (I do not remember exact number).