To: 2MAR$ who wrote (29010 ) 7/29/2012 6:45:00 PM From: 2MAR$ Respond to of 69300 The significnce of the fusion of human Chromsome #2 (Hox gene & walking upright ?) from chimp/ape chromsomes 2a & 2b recap : Chromosome #2 may have been associated with the development of bipedalism (walking upright), because the fusion of chromosomes could have altered the function of the Hox B genes which are now found on our chromosome two. The Hox B genes are one of several groups of genes which control morphology, and the Hox B genes (on chromosome 2) specifically control the way the pelvis and lower spine and genitalia develop. Humans have five lumbar vertebrae, chimps have three, so it's very plausible that that's one of the changes that led to walking upright. "They also pointed out that the family structure of chimpanzee-like creatures may well have led to quick speciation. With a dominant male impregnating multiple females, the family clan would quickly have multiple children and grandchildren with at least one fused chromosome, and inbreeding would have led to a number of individuals with two fused chromosomes - and if those individuals with 23 chromosome pairs were better able to walk upright, and this offered a significant survival or reproductive advantage, it might take no time at all before you had a new species, living with their cousins, but perhaps preferring to mate with their like, and eventually competing with and/or separating from the original species. http://richarddawkins.net/discussions/642203-how-did-the-fusion-of-chromosome-2-get-passed-on-to-future-generations#page2 * They also suggested that the considerable brain area devoted to grasping by the panids' feet would pro bably have then be devoted to other skills." When 2A & 2B fuse together, it creates a super-chromosome which attracts a 2A and 2B to the right places. This means that chromosome fusion doesn't affect either mitosis or meiosis The probability of this happening for any one such mutation and the number of generations it will take for that mutation if it does happen are respectively inversely and directly proportional to the population size. Theoretically, if you know how often chromosomes fuse you can calculate how often in 100 million years a chromosome fusion should become "fixed" in a species The fused chromosome will never go to 100% in the current population of almost 7 billion, but if there was a global catastrophe that reduced the human population to just a few thousand, as happened 70,000 years ago with the eruption of Toba, and if the fused chromosome or a new one arose in a few of the individuals, then neutral drift allows it to go to dominance by just chance .You don't need two individuals with the chromosome fusion mating. Just one is enough, as happens with any genetic variation occurring in small populations