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To: koan who wrote (33)	7/31/2012 1:36:04 AM
From: Wharf Rat	Read Replies (1) \| Respond to of 129

There's not enuf to matter. Don't you ever bike in traffic? Docs actually use CO to measure how well lungs work. All methods for measuring diffusing capacity in clinical practice rely on measuring the rate of carbon monoxide uptake and estimating carbon monoxide driving pressure. 12 The most widely used and standardized technique is the single-breath breath-holding technique. In this technique, a subject inhales a known volume of test gas that usually contains 10% helium, 0.3% carbon monoxide, 21% oxygen, and the remainder nitrogen. The patient inhales the test gas and holds his or her breath for 10 seconds. The patient exhales to wash out a conservative overestimate of mechanical and anatomic dead space. Subsequently, an alveolar sample is collected. DLCO is calculated from the total volume of the lung, breath-hold time, and the initial and final alveolar concentrations of carbon monoxide. The exhaled helium concentration is used to calculate a single-breath estimate of total lung capacity and the initial alveolar concentration of carbon monoxide. The driving pressure is assumed to be the calculated initial alveolar pressure of carbon monoxide. The calculated DLCO is a product of the patient's single-breath estimate of total lung capacity multiplied by the rate of carbon monoxide uptake during the 10-second breath hold. clevelandclinicmeded.com