To: Pancho Villa who wrote (918 ) 12/2/1997 7:35:00 AM From: Banjoman Respond to of 1359
>> Please read my previous posts as if anything the evidence that has developed since I started posting further supports my points. [Also read the Barrons piece again if you did not] << Pancho: I also think that the evidence in the news articles so far available are pretty weak (w/r/t Redux), with the exception of the Mayo Clinic report at the Cancun conference. The earlier reports had so few Redux cases that conclusions about Redux were impossible. I think it is likely that IPIC will end up with no liability, on the following basis: 1) Significant probability that Redux will not be found to cause the valve problems based on: long-period of use in Europe without reported problems; small studies of short-term users in US (up to 6 mos) showed no problem (as reported in WSJ); Redux was only on market in US a short-time before withdrawal; Note that the Cancun study undermines this. Even though Neuro determined that the incidence of problems with Redux was less than for other drugs tested, it was still substantially higher than control incidence. If the echo readers were properly blinded, I see no reason for this difference. On the other hand, the 13% incidence of 40 patients (taking Redux alone) means that 5 patients were found to have valve problems - a pretty small number. And these patients, though matched in height/weight could well be different in other ways (diet/lifestyle) from the drug group since they were matched afterwards, and we know they were different in that they were willing to try a drug to reduce their obesity. 2) The limited evidence I have seen suggests that IPIC's liability would be limited even if Redux does cause valve problems. Because: AHP, not IPIC, sold the drug; the recall was immediately on learning of the possibility of valve problems; limited evidence suggests the valve problems may be reversible. I am also comforted by Neuro's investigation and the report from Lehman, since I am confident that both parties did due diligence with attorneys (I have not done so myself). On the other hand, I recognize that these types of suits may have tremendous costs in management time and legal expenses even if no real liability exists, and that settlements may be large even if no real liability exists. So I think there are risks here, as well. To determine if IPIC is a good value, one must figure its value ignoring the Redux issues, and then haircut them (by either increasing discount rates, or based on probability of occurence). I figure that IPIC is worth $30/share ignoring IPIC. If we assume that IPIC is worth $0 if the legal menace pans out, the current market price indicates a 60% chance of IPIC being liable. Based on the information I have, I think that the real probability is lower and IPIC is undervalued.