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Biotech / Medical : Ionis Pharmaceuticals (IONS) -- Ignore unavailable to you. Want to Upgrade?

To: Miljenko Zuanic who wrote (1367)	12/5/1997 1:18:00 AM
From: james	Read Replies (1) \| Respond to of 4676

MZ, thanks <<I think that they are. Highly polar and hydrophilic they are able to penetrate under the skin by diffusion. >> Do you mean current 2302 p2 formula is topical? cream-type? Polar/hydrophilic help skin penetration, since AS works intracellularly, would cell membrane be a problem, which is non-polar/hydrophobic? Would lipo/suger coating of AS help? Please keep me info, this is getting interesting. regards ps systematic delivery << IV max side-effect & mini efficacy, lengthens p2/p3>>, & decreases NDA chance generally (proteins, compounds & AS) for localized & chronical diseases. WAGS (gggggg)