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Biotech / Medical : Depotech(depo) -- Ignore unavailable to you. Want to Upgrade?


To: Czechsinthemail who wrote (343)12/5/1997 1:21:00 PM
From: Tom D  Read Replies (1) | Respond to of 887
 
Did that 45,000 share order today belong to you? I know that it seems like a lot of your postings mention that you bought more shares again. Are you trying to outbuy me or what? My father bought 12,000 DEPO and my brother got 4,000. How many of your relatives are into DEPO? Let me see you top that!

:>)

Tom D



To: Czechsinthemail who wrote (343)12/5/1997 7:29:00 PM
From: chirodoc  Respond to of 887
 
<<<<e Depo formulations of the HIV protease inhibitor cocktails?

.............you asked the right guy--tom instead of me.

............but i think if they get approval on cytarabine they will move ahead with morphine and antibiotics.

.............i would imagine that if one drug gets approval the lipid matrix will be a shoe in for many other types of drugs. IF........IF.......a big if that is

.............if it is true and the lipid sandwich is as innocuous as it sounds, those who sell on the 19th will be buying in when the other products announce positive pII/III trials.



To: Czechsinthemail who wrote (343)12/5/1997 10:13:00 PM
From: Tom D  Respond to of 887
 
I don't think DepoFoam will be adaptable to oral use.

You would have to put an enteric coating on it so that it is resistant to destruction from gastric acid. With or without the coating, the depofoam would be eliminated by the gastrointestinal system within about 24 hours, largely intact.

Best Regards,

Tom D



To: Czechsinthemail who wrote (343)12/6/1997 12:51:00 AM
From: chirodoc  Respond to of 887
 
<<<<<Continuing the creative uses of DepoFoam technology possibilities

<<<<<HIV protease inhibitor

...you have probably seen this--but for those who have not--studying anti-retrovirals and interferon
Publications

Please send the following publications:
(Select all appropriate boxes.)

Product Literature:

DepoAmikacin product literature

DepoCyt product literature

DepoMorphine product literature

Investor Relations Literature:

DepoTech Investor Relations Package, including 1996 Annual Report

DepoTech 1996 Annual Report

Company Publications:

24. Topology of Multivesicular Liposomes, A Model Biliquid Foam,

Langmuir Vol. 12 No. 20: 4704-4708, October 12,1996.
M.S. Spector, J.A. Zasadzinski, M.B. Sankaram.

23. An Electron Microscopy Study of the Structure of Multivesicular Liposomes,
BioMedical Research Foundation, Tokyo,
Progress in Drug Delivery System Vol. 5, 1996.
M.S. Spector, J.A. Zasadzinski, M.B. Sankaram.

22. Sustained-release Morphine for Epidural Analgesia in Rats,
Anesthesiology 85: 331-338, August 1996. Tahehee Kim, Sharad
Murdande, Andras Gruber, Sinil Kim.

21. Soft Tissue Infection Prophylaxis with Gentamicin Encapsulated in
Multivesicular Liposomes: Results From a Prospective, Randomized Trial,
Critical Care Medicine 23: 84-91, January 1995. Lelia S. Grayson, John F.
Hansbrough, Ramon Zapata-Sirvent, Ansgar J. Roehborn, Taehee Kim, Sinil Kim.

20. DepoFoam-Mediated Drug Delivery into Cerebrospinal Fluid,
Methods in Neurosciences 21: 118-131, 1994. Sinil Kim.

19. An Extended-Release Formulation of Methotrexate for Subcutaneous Administration,
Cancer Chemother Pharmacol 33: 303-306, 1994. Andrea Bonetti, Etienne Chatelut, Sinil Kim.

18. Sustained-Release Methotrexate for Intracavitary Chemotherapy,
Journal of Pharmaceutical Sciences 83: 429-432, March 1994. Etienne Chatelut, Peter Suh,
Sinil Kim.

17. Pharmacokinetics of an Extended-Release Human Interferon Alpha-2b Formulation,
Cancer Chemother Pharmacol 33: 258-261, 1993. Andrea Bonetti, Sinil Kim.

16. Liposomes as Carriers of Cancer Chemotherapy: Current Status and Future
Prospects,
Drugs 46 (4): 618-638, 1993. Sinil Kim.

15. Extended-Release Formulation of Morphine for Subcutaneous Administration,
Cancer Chemother Pharmacol 33: 187-190, 1993. Taehee Kim, Joon Kim, Sinil Kim.

14. Extended CSF Cytarabine Exposure Following Intrathecal Administration of
DTC101,
Journal of Clinical Oncology 11: 2186-2193, November 1993. Sinil Kim, Etienne Chatelut,
Joseph C. Kim, Stephen B. Howell, Charles Cates, Patricia A. Kormanik, Marc C. Chamberlain.

13. Prolongation of Drug Exposure in Cerebrospinal Fluid by Encapsulation into
DepoFoam,
Cancer Research 53: 1596-1598, April 1993. Sinil Kim, Shirin Khatibi, Stephen B. Howell,
Cindy McCully, Frank M. Balis, David G. Poplack.

12. Quantitative Cerebrospinal Fluid Cytology in Patients Receiving Intracavitary
Chemotherapy,
Annals of Neurology, 34: 108-112, July 1993. Valentina Russack, M.D.; Sinil Kim, M.D.;
Marc C. Chamberlain, M.D.

11. A Slow-Release Methotrexate Formulation for Intrathecal Chemotherapy,
Cancer Chemother Pharmacol 32: 179-182, 1993. Etienne Chatelut, Taehee Kim, Sinil Kim.

10. Treatment of Leptomeningeal Metastasis with Intraventricular Administration of
Depot Cytarabine (DTC101),
Arch Neurol 50: 261-264, March 1993. Marc C. Chamberlain, M.D.; Shirin Khatibi, D.V.M.;
Joseph C. Kim; Stephen B. Howell, M.D.; Etienne Chatelut, Ph.D.; Sinil Kim, M.D.

9.ÿÿ Pharmacokinetics of DepoFoam Gentamicin Delivery System and Effect on Soft
Tissue Infection,
Journal of Surgical Research 54: 559-564, January1993. Leila S. Grayson, M.D.;
John F. Hansbrough, M.D.; Ramon L. Zapata-Sirvent, M.D.; Taehee Kim, Sinil Kim, M.D.

8.ÿÿ Multivesicular Liposomes Containing Bleomycin for Subcutaneous Administration,
Cancer Chemother Pharmacol 28: 105-108, 1991. Romi Roy, Sinil Kim.

7.ÿÿ Direct Cerebrospinal Fluid Delivery of the Antiretroviral Agent Using Multivesicular
Liposomes,
Journal of Infectious Diseases 162: 750-752, September 1990. Sinil Kim, Shelia Scheerer,
Mark A. Geyer, Stephen B. Howell.

6.ÿÿ Intratumoral Chemotherapy with Multivesicular Liposomes Containing Cytosine
Arabinoside,
Reg Cancer Treat 2: 170-173, 1989. Sinil Kim, Shirin Khatibi, Stephen B.
Howell, Sheila Scheerer.

5.ÿÿ Modulation of the Peritoneal Clearance of Liposomal Cytosine Arabinoside by Blank
Liposomes,
Cancer Chemother Pharmacol 19: 307-310, 1987. Sinil Kim, David J. Kim, Stephen B. Howell.

4.ÿÿ Multivesicular Liposomes Containing Cytarabine Entrapped in the Presence of
Hydrochloric Acid for Intracavitary Chemotherapy,
Cancer Research 47: 3935-3937, August 1987. Sinil Kim and Stephen B. Howell.

3.ÿÿ Multivesicular Liposomes Containing 1--D-Arabinofuranosylcytosine for
Slow-Release Intrathecal Therapy,
Cancer Treatment Reports 71: 705-711, July 1987. Sinil Kim, David J. Kim, Mark A. Geyer,
Stephen B. Howell.

2.ÿÿ Multivesicular Liposomes Containing Cytarabine for Slow-Release Sc
Administration,
Cancer Treatment Reports 71: 447-450, May 1987. Sinil Kim, Stephen B. Howell.

1.ÿÿ Preparation of Multilamellar Vesicles of Defined Size-Distribution by
Solvent-Spherule Evaporation,
Biochimica et Biophysica Acta 812: 793-801, 1985. Sinil Kim, Russell E. Jacobs, Stephen
H. White