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Biotech / Medical : Agouron Pharmaceuticals (AGPH) -- Ignore unavailable to you. Want to Upgrade?

To: Oliver & Co who wrote (3192)	12/7/1997 3:13:00 PM
From: JOHN W.	Respond to of 6136

NEWTOWN, Pa., Dec 5 (Reuters) - CollaGenex Pharmaceuticals Inc said Friday that the National Cancer Institute has filed an Investigational New Drug application for Metastat, the company's lead compound for the inhibition of cancer invasion and metastasis. It is anticipated that clinical studies in patients with metastatic cancer will begin early in 1998, pending approval by the FDA. Metastat is the first of CollaGenex's novel ''chemically modified tetracyclines,'' developed in conjunction with a laboratory at the State University of New York at Stony Brook. These compounds, which have been chemically stripped of their antimicrobial properties, behave as inhibitors of a key group of enzymes known as matrix metalloproteinases (''MMPs''). It said the National Cancer Institute ''has supported this program throughout.'' MMPs are involved in the processes which cause cancer to spread, or metastasize, in the human body.

To: Oliver & Co who wrote (3192)	12/7/1997 5:50:00 PM
From: billkirn	Read Replies (4) \| Respond to of 6136

If Amprenavir(141W94} doesn't show significant improvement over existing PIs, will the FDA put it on a slow approval track? I think fast track would be ~6 months after NDA. I am guessing they will file in March-June time frame and if not on fast track might get approval as late as mid 1999. Any input on this time line appreciated. I also picked up 1k shares at 28. The charts have turned and we should get a few months up. I am looking for mid 40's over this time frame. Can't wait to hear Peter on CNBC tomorrow. Bill