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To: puborectalis who wrote (14114)	12/8/1997 10:23:00 AM
From: margaret tasset	Read Replies (1) \| Respond to of 27012

Stephen, I agree with you that genetics is important (and BTW that was one of my very favorite subjects in school, but I also think that you can have great influence on your health by having healthy lifestyles. I hope that you are having a good day. Go INTEL Health and Prosperity Margaret

To: puborectalis who wrote (14114)	12/8/1997 12:58:00 PM
From: JPR	Read Replies (1) \| Respond to of 27012

Stephen: Greetings OTOTOT <<Paul..genetics are a lot more important than any fatty acids.>>> Genes, Fatty Acids, Cholesterol HDL and Heart Disease Let me narrate a real-life story: Once upon a time (in the 1780s), there lived an Italian , by name Cristoforo Pomaroli and his significant other by name Rosa Giovanelli. Cris and Rosa had a few children. The descendants lived in Limone Italy, not knowing that they had an inherited disease. The 38 descendants of Rosa and Cris had a simple mutation in the carrier protein of the so-called good Cholesterol - HDL Cholesterol. These descendants ranged in age from the teens to octogenarian. They all lived for a long time and never did one die of heart disease or stroke. How is that possible.? They were eating their sausages, red meat and butter and more butter. It is not the olive oil that protected them. News got around and reached Dr. Cesare Sirtoli of the University of Milan. Dr. S wondered , & wandered to Linone to see the lucky Octogeneraian and the rest of the hearty bunch . He thought that there must be something wrong or may something radically right about the longevity of these village people. Dr. Sirtoli did research ,put two and two together and called the mutation as APOLIPOPROTEIN A-1 MILANO. Now Dr. Sirtoli, the Professor of Pharmacology at the University of Milano wondered what if he could confer this protection to everybody to save the world from coronary heart disease. He even thought the unthinkable to transfer somehow these mutant gene to the liver of all those poor high-risk , heart-attack prone people all over the world. Dr.Sirtoli wrote to all the specialists in the ivory-tower Universities in Europe. No body paid any attention and they thought that this Dr. Sirtoli is .......... Eventually The swedish biotechnology firm Pharmacia A.B began producing the lab. version of APO A1 Milano. His fame and name spread to all the right people and Dr. Prediman K.Shah, Director of the cardiac Care unit at Cedars-Sinai Medical Center in Los Angeles got infected with Dr. Sirtoli's enthusiasm. Dr. Shah heads the Swedish- US team working hard to prevent or reduce reclogging of the coronary blood vessels after balloon angioplasty surgery. Dr. Shah then starts injecting a genetically engineered version of this mutant protien . Lo and behold the coronary arteries were not reclogged in his patients. His patients were bunny rabbits! Eight bunnys got injection of APO MILANO attached to the fat molecule and the other poor control group rabbits got only the fat molecule. The APOMILANO with fat molecule, upon injection goes to its receptor site like a key to its lock . He called 4 rabbits and told them that they are the controls with no injections, but he added they can eat their lettuce and carrots. Shah found that the APO MILANO Rabbits had 70% reduction in the artery-clogging plaque than the controls. Shah went one step further and decided to test our distant cousins - the monkeys - the pigs and mice before he will test us the humans. The Limone patients had sky-high cholesterol and triglycerides, but no coronary artery disease, because of mutated gene that conferred a high level of HDL and coronary artery protection. End of the story Paul