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Biotech / Medical : Alteon (ALT) -- Ignore unavailable to you. Want to Upgrade?

To: Jonathan Rothschild who wrote (193)	12/10/1997 10:07:00 AM
From: Mac S. Giballa	Respond to of 318

Wrong on all counts. 1300 compounds have been researched to block AGE production, aminoguanidine was the earliest, and is still the second strongest, ALTN also has the strongest one also. Counterfeiters???- I suggest you get yourself some prescription Haldol. Stick to the real issues, lets not introduce SI garbage onto this one. If you want to make a little money on the short side in the short term give it a shot, but watch out, the biotech analysts have been waiting for a comarketing agreement. You'll next be seeing a series of buy recommendations. Good luck to ya...

To: Jonathan Rothschild who wrote (193)	12/10/1997 10:38:00 AM
From: Rudy Saucillo	Read Replies (1) \| Respond to of 318

Counterfeiters??? That simply should not be a concern when developing sales projections for Pimagedine. No one but ALTN/GNE will have the regulatory approval or legal authority to sell Pimagedine (i.e., assuming the ongoing trials are successful). Yes, other companies are researching AGE formation inhibitors which are structurally different than Pimagedine. I can post more info on these if anyone is interested. All of these are in the early pre-clinical stage and none are competitive with ALTN's. Alteon's second generation program is significantly ahead of these other efforts. I'm not implying there's no competition for marketshare. There's much work ongoing in the areas of diabetic complications and metabolic control. But diabetes is a very complex disease and (short of transplantation for Type I disease) there's no one-therapy cure. Because of the broad systemic effects of Pimagedine, I believe Pimagedine will become a major component in future multi-drug approaches in diabetes treatment. Rudy