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To: John McCarthy who wrote (282)	12/13/1997 3:36:00 PM
From: John McCarthy	Read Replies (1) \| Respond to of 569

Note:Hylan G-F 20 is Synvisc in this study Note:After 26 weeks! At 26 weeks both groups receiving hylan G-F 20 were significantly better than the group receiving NSAIDs alone. A transient local reaction was observed in three patients after hylan G-F 20 injection; only one patient withdrew from the study as a result and all recovered without any sequela. Hylan G-F 20 is a safe and effective treatment for OA of the knee and can be used either as a replacement for or an adjunct to NSAID therapy. ncbi.nlm.nih.gov Regards, John

To: John McCarthy who wrote (282)	12/13/1997 4:24:00 PM
From: John McCarthy	Read Replies (1) \| Respond to of 569

Comments from an MD ... same news site: Hi this is hualuronic acid which is the primary component of joint fluid and a major component of all connective tissue in varing ampunts two products are presently available Hyalgan and Synvisc there are differences in the products but which works best is not really known and probably varies widely form preson to person so far in my early limited experience it has been pretty suscessful in "inproving" the patient those with lesser arthritis seem to respond better which is not surprising no signifigant side effects have been noted by myself nor have many been reported I think that this "stuff" is a good tool to have added to our bag of tricks for dealing with troubled joints it is cleared for the knee only now but there is no reason to think it would not be suscessful elsewhwere and there is literature to support that getting payment for it as well as much of anything else in medicine at this time is kind of problematic happy holidays ken merriman md Griselda <jarnsaxa@localip.net> wrote in article <01bd052b$af5a3860$29d253d1@jarnsaxa.lips.net>... > One of our local news stations broadcast a story tonight about a potential > new treatment for osteoarthritis in the knees, involving an injection of > synovial fluid replacement into the knee joint. > > They said that the technique was derived from a similar technique used on > race horses and show-jumpers to treat their arthritis, and seems to work > rather well on humans, too. They also noted that the procedure was > approved just 2 months ago. > > Has anyone heard anything about this or tried this therapy? I'd be > interested in information both pro and con if any is available. > > Thanks, > > Griselda > --

To: John McCarthy who wrote (282)	12/13/1997 5:26:00 PM
From: John McCarthy	Read Replies (1) \| Respond to of 569

Some pretty harsh NSAIDs numbers .... Overprescription of non-steroidal anti-inflammatory drugs A recent study examined cases in which physicians were thought to overprescribe non-steroidal anti-inflammatory drugs (NSAIDs) for the treatment of arthritis in elderly patients. - experts say use of the drugs by elderly persons results in increased risk of stomach bleeding and ulcers, and note that the drugs are linked to an estimated 7,600 deaths and 76,000 hospitalizations in the U.S. every year. - elderly persons with peptic-ulcer disease and high blood pressure are known to be at up to six-times the risk of NSAID-related complications than others. - Canadian researchers found that of 57 cases in which NSAIDs were prescribed for osteoarthritis, only 19 cases involved assessment of risk factors for the drugs. - according to the American College of Rheumatology, NSAIDs should only be prescribed when other treatments have failed. - the study is in the Annals of Internal Medicine (1997;127:429-438). mediconsult.com Regards, John