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Biotech / Medical : NNVC - NanoViricides, Inc. -- Ignore unavailable to you. Want to Upgrade?

To: DaBoze who wrote (4535)	4/19/2015 1:01:50 PM
From: drkaz	Read Replies (1) \| Respond to of 12871

Keep in mind several factors DaBoze. 1) One of the reasons that the 'Kg' quanties of Flucide are needed for TOX testing is that the compounds appears to be so non-toxic. The theraputically active (the amount needed to be effective as a treatment) dosage is going to be far below the quantity needed to do TOX testing and figure out whether the 'Cide has significant toxic effects in a living animal's system. Synthesis of 'g' quantities of 'Cides has been figured out for quite a while - and for the testing on small animals (mice & rats) those were more than sufficient to get the job done. 2) With emphasis on the 'small animals',.... if a typical mouse weighs ~20-30 g, and a typical adult Beagle weighs ~10 Kg (~20-25 lb) or 10,000 g,..... to get the same per gram dose per animal you will need in the ballpark of 400x as much Flucide. So a given quantity of Flucide will go a lot further in 'small animal' testing or studies in cell cultures. 3) Also keep in mind,.... those 6000+ animals in previous testing were not all done in a single experiment. Small batches would have been more than sufficient. That's what you have to keep in mind in order to wrap your head around these facts. It's really that simple. Do I know the specific quantities that NNVC needed in order to do each set of experiments? No. Could probably estimate it out if I went digging. But the short answer is,.... they didn't need anywhere near as much as they need to get this to the next stages of testing,.... Clinical testing that is.