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To: E. Charters who wrote (12998)11/24/2015 1:43:46 AM
From: Metacomet  Respond to of 17098
 
..agree with the CoQ10, but I suggest the Ubiquinol form as it has an order of magnitude greater bioavailability in that form than straight CoQ10

en.wikipedia.org

..although it costs a more, you can get similar benefit with a much smaller dose, so the benefit/cost ratio is similar

I use this stuff

costco.com



To: E. Charters who wrote (12998)11/24/2015 12:03:15 PM
From: Pogeu Mahone  Respond to of 17098
 
Eat Real Food!

Which Foods are Rich in CoQ1

Last Updated: Jan 10, 2014 | By Melodie AnneCoQ10 is naturally found in high levels in organ meats such as liver, kidney, and heart, as well as in beef, sardines, and mackerel. Vegetarians or vegans who are used to eating these foods should find a suitable alternative. Luckily, vegetable sources of CoQ10 include spinach, broccoli, and cauliflower.


Coenzyme Q-10 helps produce energy and neutralizes harmful free radicals. When you have enough coenzyme Q-10 in your system, the fat-soluble nutrient can help protect all cells, reducing your overall risk of developing chronic diseases. Your body synthesizes some coenzyme Q-10 on its own, but you can get some from your diet as well.

Fatty FishBecause coenzyme Q-10 is fat soluble, requiring fat for absorption and storage, generally the more fat in the fish you prefer, the more coenzyme Q-10 you’ll get. Opt for fatty cold-water fish like salmon, tuna and herring. Three ounces of cooked herring, for example, has 2.3 milligrams. A less fatty variety, such as rainbow trout, has closer to 0.9 milligram of coenzyme Q-10, from a 3-ounce steamed serving.

Beef and chicken are some of the richest sources of coenzyme Q-10. A 3-ounce cooked serving of beef, which is roughly the size of a deck of cards, contains approximately 2.6 milligrams of the nutrient. A similarly sized portion of chicken has about half that amount -- roughly 1.4 milligrams of coenzyme Q-10. You’ll even get a small amount of coenzyme Q-10 from an egg. A medium hardboiled egg offers 0.1 milligram.



To: E. Charters who wrote (12998)11/25/2015 5:26:13 PM
From: Pogeu Mahone  Respond to of 17098
 



To: E. Charters who wrote (12998)12/10/2015 8:44:53 AM
From: Pogeu Mahone2 Recommendations

Recommended By
E. Charters
Yorikke

  Respond to of 17098
 
Ian@SI12/8/2015 8:07:36 PM
1 Recommendation of 45062
Perhaps this explains why [anecdotally] Vitamin D is protective for MS pts.

eurekalert.org

A supplement for myelin regeneration Rockefeller University Press



IMAGE: In a control brain slice (left), most axons (red) have regained a myelin sheath (green) eight days after demyelination. But regeneration is impaired when VDR is inhibited (right). view more

Credit: De la Fuente et al., 2015

Multiple sclerosis patients continually lose the insulating myelin sheath that wraps around neurons and increases the speed of impulses in the central nervous system. Whenever neurons are demyelinated, OPCs migrate toward these cells and differentiate into mature, myelin-producing oligodendrocytes, but this process becomes less and less effective as people age.

A nuclear receptor protein called retinoid X receptor gamma (RXRgamma) is known to promote OPC differentiation and remyelination, but, because nuclear receptors generally function in pairs, a team of researchers led by Robin Franklin at the University of Cambridge, UK, set out to identify RXRgamma's binding partners and investigate their possible role in remyelination.

RXR? bound to several nuclear receptors, including VDR, in OPCs and mature oligodendrocytes. Inhibiting VDR impaired OPC differentiation and reduced the cells' ability to remyelinate axons ex vivo. In contrast, Vitamin D, which binds and activates VDR, boosted OPC differentiation.

Low vitamin D levels have been linked to the onset of multiple sclerosis, and the researchers' findings suggest that the vitamin might also affect disease progression by controlling myelin sheath regeneration, a critical step to alleviate the disease's symptoms that fails as patients age. VDR-activating drugs might therefore be able to enhance remyelination in multiple sclerosis patients and in patients suffering from other demyelinating diseases.

###

De la Fuente, A.G., et al. 2015. J Cell Biol. dx.doi.org

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To: E. Charters who wrote (12998)1/12/2016 7:10:15 PM
From: Pogeu Mahone  Respond to of 17098
 
Health and Hair: The Color ConnectionWhat Your Natural Hair Color Says About Your Health

By Gina Roberts-Grey, Special to Lifescript
Published October 24, 2015

VIEW 58 COMMENTS



Do blondes have more fun? Maybe, but they face a greater risk for eye diseases than brunettes. And redheads? Get ready for pain! Here’s what your natural hair color says about your health…

Does your dentist, ophthalmologist or dermatologist ask, “Is that your natural hair color?”

They’re not being nosy. They’re thinking about your health.

In fact, your health and hair are more interconnected than you may realize. There's a strong link between a woman’s natural hair color and her chances of developing diseases and disorders, a decade's worth of clinical studies show.

The reason: The genes that give your hair a charcoal, chestnut, honey or amber hue also affect health conditions like Parkinson’s, multiple sclerosis and endometriosis, says Cleveland Clinic geneticist Rocio Moran, M.D.

That's because “the melanocytes, or DNA, that produce hair pigment are controlled by genes that have roles in other processes in the body,” she says.

What does your natural hue say about your health? Our experts have color commentary…

Redheads
More sensitive to pain
Before plopping down in the dentist’s chair, you might want to pop an ibuprofen (Advil). And make sure you remind the hygienist and dentist that you’re a natural redhead.

Ginger-haired people tend to be particularly resistant to local anesthetics used in dentistry, according to a 2009 Cleveland Clinic study. Besides making for a painful cleaning – not to mention root canal – that hypersensitivity to pain may lead to anxiety about dental procedures.

Redheads may require up to 20% more local anesthesia (Novocain or other, similar pain-numbing drugs) than other colors, says the study’s lead researcher, Cleveland Clinic anesthesiologist Daniel Sessler, M.D.

That’s because redheads’ melanocortin-1 receptors (the DNA responsible for hair color) are malfunctioning. In fact, red hair itself is the result of a gene mutation.

Painful procedures can lead women to avoid going to the dentist, says Dr. Sessler, who adds that this sensitivity also applies to surgical procedures. Redheads often require more general anesthesia then too.

VIEW 58 COMMENTS



The best way to avoid unnecessary pain: Talk to your dentist before having any work done, says Dr. Sessler.

“Establish a method [before the procedure], for example, raising a finger, to communicate discomfort, so additional pain-block medicine can be administered.”

Higher risk for Parkinson’s
Redheads have nearly a 50% greater chance of developing Parkinson's than people with other hair colors, according to a 2009 Harvard Medical School study. People with black hair have the lowest chance, followed by brunettes, then blondes, researchers found.

The gene responsible for fiery hair hues is headquartered close to a gene that, if mutated, can increase the risk for Parkinson's disease. And proximity can be all it takes to make one gene affect another.

“The lighter the hair, the stronger the likelihood of developing the ‘bad’ variant of the Parkinson’s gene,” says Svetlana Kogan, M.D., an internist at Lenox Hill Hospital – and a natural redhead.

“We found that [people] with a family history of melanoma had an increased risk of Parkinson’s,” says one of the Harvard researchers, Xiang Gao, M.D., Ph.D., instructor in medicine at Harvard Medical School and associate epidemiologist at Brigham and Women's Hospital.

VIEW 58 COMMENTS


Because redheads face higher risk of melanoma, Parkinson’s and melanoma “may share genetic components, most likely the genes related to pigmentation,” Dr. Gao says.

High-strung
Reds are often more anxious than other colors. That’s because the same genetic factors that control melanin production (the DNA that gives hair its color) also affect how your body manages stress.

“The genes responsible for the ability to produce anti-stress hormones live close to melanocortin-1 receptors,” says Margaret Lewin, M.D., a New York internist.

And sometimes the gene mutation that causes red hair can lead the anti-stress genes astray, too, and cause faulty production of anxiety-reducing hormones like pregnenolone. “The decreased production of anti-stress hormones leaves a redhead more likely to be stressed out,” Dr. Lewin says.

Blondes
Prone to eye issues
Buy UV-blocking shades, if you haven’t already. Age-related macular degeneration, an eye disease that may cause blindness, strikes women more often than men, and blondes more than other natural hair colors.

“The fairer your hair, the greater your risk,” Dr. Kogan says. And if you have blue eyes too, you’ve increased the odds.

“Although the exact link isn’t fully understood, the lack of pigment to protect blondes’ eyes from the sun’s retina-damaging rays may be a cause,” Dr. Kogan says.

Greater chance of skin cancer
It’s no secret that fair skin increases your chances of melanoma, but light hair is a risk factor too.

Researchers at Harvard say that no matter your skin tone, blondes should never leave home without slathering on a full-spectrum UVA and UVB sunscreen with at least 30 SPF.

“Blondes produce less melanin, the cells that give your hair and skin its pigment. [It] can leave them especially sensitive to sunburns, sun damage and developing skin cancer,” says dermatologist Joel Schlessinger, M.D., president emeritus, American Society of Cosmetic Dermatology and Aesthetic Surgery.

And just because the sun isn’t shining, that doesn’t mean you’re safe from its rays.

“You can get a nasty sunburn when it’s partly cloudy too,” Dr. Schlessinger says.


Most likely to shine
Blondes always get credit for having all the fun, but now there’s scientific proof that they’re living it up with some of the shiniest hair too.

Blonde hair has different characteristics than brunettes and reds, which allow it to reflect light better while still appearing to have a soft, warm tone, according to a 2009 study published in the Journal of Cosmetic Science.

Brunettes
More likely to smoke
Dark-complected people are more susceptible to nicotine dependence, according to a 2009 Pennsylvania State University study.

The melanin that gives your hair its chocolately color also slows your liver’s ability to metabolize nicotine, making it stay in your system longer. That makes you more likely to become dependent on cigarettes, Dr. Lewin says.

Lower risk of skin cancer
Many studies have linked brunettes with decreased odds of developing a host of health conditions, from melanoma to endometriosis.


And a 2008 Australian study found brunettes have less of a chance of developing multiple sclerosis.

“In most cases, brunettes tend to have darker complexions than blondes and redheads, which seems to provide some protection from multiple sclerosis,” Dr. Schlessinger says.

More likely to get lymphoma
Unless it’s jet-black, the darker your hair, the greater your chances of developing non-Hodgkin’s lymphoma (NHL), according to the National Cancer Institute’s Division of Cancer Epidemiology and Genetics.

“Women with dark hair often have a certain DNA coding that not only affects pigment, it increases the risk for this disease,” says lead researcher Marit Bragelien Veierød, Ph.D., of the Institute of Basic Medical Sciences in Oslo, Norway.

But interestingly, black hair did not carry the increased risk like brunette hair did.

Damsels NOT in distress
Perhaps if she had black hair, Rapunzel wouldn’t have needed rescuing. According to a study published in U.S. journal Perceptual and Motor Skills, women with black hair are least likely to be seen as needy or in distress.



Gray
Your genes don’t change when your hair grays.

The DNA that once made your locks red, blonde or brown is part of your chemical make-up, even if your hair color shifts toward silver.

“If you’re a natural redhead, you’ve still got an increased risk of Parkinson’s,” Dr. Moran says.

Family history and age are the major factors that influence when hair color changes.

But if it goes gray before your peers or seems to change more quickly, that could be the sign of other health issues.

“Stress, smoking - which has been linked to cell damage - vitamin B12 deficiency and thyroid disorders can cause the body to stop making pigment, leading to premature or sudden graying,” Dr. Moran adds.







To: E. Charters who wrote (12998)2/1/2016 7:37:18 AM
From: Pogeu Mahone  Read Replies (1) | Respond to of 17098
 
Young at heart? Not most Americans, government report says

Monday, February 1, 2016
By MIKE STOBBE, AP MEDICAL WRITER ~ TBY


Stock photo

NEW YORK (AP) -- Your heart might be older than you are. A new government report suggests age is just a number -- and perhaps not a very telling one when it comes to your risk of heart attack or stroke.

The Centers for Disease Control and Prevention report takes a new approach to try to spur more Americans to take steps to prevent cardiovascular disease. CDC scientists estimated the average "heart age" of men and women in every state, based on risk factors like high blood pressure, obesity and whether they smoke or have diabetes. Then it compared the numbers to average actual ages.

The results?

Nearly three out of four U.S. adults have a heart that's older than the rest of their body, according to CDC calculations.

For U.S. men on average, the predicted heart age was nearly eight years greater than their real age. For U.S. women, it was about five and a half years.

"This is alarming. Heart disease is the nation's No. 1 killer," says the report's lead author, CDC scientist Quanhe Yang. "But the bottom line is you can do some very simple things" to become younger at heart, he says.

Each year, one in four U.S. deaths is due to heart disease. Many are heart attacks and strokes. The average age of first heart attack is about 64 1/2 for men and 72 for women, according to the American Heart Association.

The nation's heart disease death rate has been falling thanks to advances in prevention and treatment, including drugs to control blood pressure and lower cholesterol.

But heart disease remains America's leading cause of death and health officials have been pushing to get more people to control their weight, quit smoking and take other steps to help their heart and blood vessels.

The CDC is leading a "Million Hearts" campaign, launched in 2012 to prevent 1 million heart attacks and strokes by 2017. CDC scientists were intrigued by a heart age calculation developed by other researchers conducting a large study in Framingham, Massachusetts.

Some research has indicated that Framingham heart age calculations have resonated more with patients than more conventional medical advice and warnings, so CDC researchers used the Framingham model -- and CDC national survey data -- to produce the first report on heart age across the nation.


In this file photo, a patient has her blood pressure checked by a registered nurse in Plainfield, Vermont. Your heart might be older than you are, according to a CDC report that takes a new approach to try to spur more Americans to take steps to prevent cardiovascular disease.

"It gives a stark, simple picture of your future risk of having -- or dying from -- heart attack or stroke," says CDC director Dr. Tom Frieden.

The estimates were specific to adults ages 30 to 74 who have not had a heart attack or stroke.

Mississippi has the highest proportion of adults with advanced heart age, followed by West Virginia, Kentucky, Louisiana and Alabama. Those states also have higher rates of smoking, obesity and other heart disease risk factors.

Utah and Colorado had the lowest proportions of people with a heart age five years or greater than their actual age, followed by California, Hawaii and Massachusetts.

The study also found that for blacks nationally, heart age was 11 years greater than actual age. The gap was much smaller for whites and Hispanics.

CDC also officials shared the Framingham study's online heart age prediction calculator for individuals to assess themselves. People have to know their systolic blood pressure -- the higher of the two measurements -- to generate an estimate.

Online:

CDC report: www.cdc.gov/vitalsigns

Heart age calculator: www.framinghamheartstudy.org/risk-functi...



To: E. Charters who wrote (12998)2/8/2016 11:17:56 AM
From: Pogeu Mahone  Read Replies (3) | Respond to of 17098
 
What have I been saying all along?

Do not supplement, eat real food for your vitamins and minerals.

From the constipated drug addicts thread:

Magnesium levels in hospitalized patients: hyper may be worse than hypo

From a recent huge Mayo Clinic database:

Patients and Methods

All admissions to Mayo Clinic in Rochester, Minnesota, from January 1, 2009, through December 31, 2013 (288,120 patients), were screened. Admission Mg from each unique patient and relevant clinical data were extracted from the institutional electronic database.

Results

After excluding patients aged less than 18 years, those without Mg measurement, and readmission episodes, a total of 65,974 patients were studied. Magnesium levels of 2.1 mg/dL or higher were found in 20,777 patients (31.5%), and levels less than 1.7 mg/dL were noted in 13,320 (20.2%). Hypomagnesemia was common in patients with hematologic/oncological disorders, and hypermagnesemia was common in those with cardiovascular disease. The lowest hospital mortality, assessed by restricted cubic spline and percentage death, occurred in patients with Mg levels between 1.7 and 1.89 mg/dL. An Mg level of less than 1.7 mg/dL was independently associated with an increased risk of hospital mortality after adjusting for all variables except the admission diagnosis; risk for longer hospital stay and being discharged to a care facility were increased in the fully adjusted model. An elevated Mg level of 2.3 mg/dL or higher was a predictor for all adverse outcomes. The magnitude of Mg elevations in patients with levels of 2.3 mg/dL or higher (N=7908) was associated with worse hospital mortality in a dose-response manner. In patients with cardiovascular diseases, Mg levels of 1.5 to 1.69 mg/dL and 2.3 mg/dL or higher both independently predicted poor outcomes including hospital mortality.

Conclusion

Dysmagnesemia in hospitalized patients is common, with hypermagnesemia being most prevalent. Compared with hypomagnesemia, hypermagnesemia is a stronger predictor for poor outcomes. Magnesium supplementation for patients without Mg deficiency should be avoided in the absence of randomized controlled trials documenting a benefit.



To: E. Charters who wrote (12998)3/27/2016 12:53:47 PM
From: Pogeu Mahone  Respond to of 17098
 
Vitamin D deficiency and autoimmune disorders


A study has linked vitamin D deficiency with an increased risk for cancer and autoimmune diseases, such as rheumatoid arthritis MS, and lupus. Researchers found, through mapping vitamin D receptors binding throughout the human genome, that vitamin D deficiency is a major environmental factor in increasing the risk of developing these disorders.

1 billion people don't get enough vitamin D


It's been estimated that 70 percent of children and adults in the U.S. are vitamin D deficient. The cause of deficiency is a combination of not getting enough exposure to the sun and not having enough vitamin D in their diets.

Medications can affect vitamin D absorption


Hydroxychloroquine, or Plaquenil, and corticosteroids, which both can be prescribed for the treatment of rheumatoid arthritis, are among these. Even if you are taking one of these drugs, your doctor can adjust your vitamin D dose to correct the malabsorption.

A blood test can determine your vitamin D level


You can ask your doctor to give you a simple blood test called, 25-hydroxy vitamin D test. It can tell you how deficient you might be in vitamin D.

Vitamin D can lift moods and strengthen bones


Not only does vitamin D play a crucial role in the absorption of calcium, but it can stave off osteoporosis, which can be a risk for people with RA. It also protects those susceptible to seasonal affective disorder from becoming depressed.

Vitamin D and chronic pain


A lack of vitamin D may play a role in chronic pain caused by a variety of conditions. Research has indicated vitamin D deficiency may be implicated in musculoskeletal conditions, such as rheumatoid arthritis, neuropathy, migraine, and inflammation.

Vitamin D can help you manage chronic pain


It's common for people who live with chronic pain to have a vitamin D deficiency. Many doctors routinely check their patients for their levels of vitamin D and often recommend vitamin D supplements as part of a treatment plan. Getting more vitamin D may help you to gradually get partial pain relief and improved mood.

How Vitamin D is Absorbed


Unlike some vitamins that begin working in the body immediately after being consumed, vitamin D must be processed by the liver and kidneys into a form (calcitriol) that can attach to vitamin D receptors in most of the body's cells. Your body stores one form of previtamin D, called dehydrocholesterol, in the skin. When your skin absorbs sunlight, it is transformed into previtamin D3 (cholecalciferol).

Vitamin D and heart disease


Studies have linked low vitamin D levels with heart disease and heart attacks. The systemic inflammation of RA affects internal organs and increases the risk of heart attack and stroke. Managing this risk includes seeing a preventative cardiologist, eating a balanced diet and maintaining a healthy weight, quitting smoking. It may also include getting enough vitamin D.

Access to vitamin D blood test


Getting your vitamin D levels tested may be a challenge. In the last 10 years, demand for the blood test has jumped 4000 percent. Some insurance plans don’t cover it and Medicare has restricted rebates for vitamin D testing to high-risk individuals, such as those with osteoporosis, deeply pigmented skin or chronic lack of exposure to the sun.