To: T L Comiskey who wrote (283454 ) 12/4/2015 12:12:09 PM From: Wharf Rat Respond to IIRC, BP at 18,000 feet is 380 mmHg, , half of sea level. There's a village in Peru named Cerro de Pasco, at about 14.5K feet. Miners work a mine at 16K feet. We'll survive. Our physiology will change. More blood cells, pH, etc. How do I know? Worked for this guy the summer of '67. I think his son is a climatologist at Scripps.5 ]. This led us to study, in ourselves, the role of CSF pH and bicarbonate in acclimatization to high altitude at the UC White Mt (CA) laboratories, a range east of the Sierra Nevada [ 6 ]. We later studied the control of cerebral blood flow (CBF) at altitude, also in each other, joined by Tom Hornbein [ 7 ] soon after his ascent of Everest by the West Ridge. We repeated these acclimatization studies in Peruvian high-altitude natives at the invitation of Alberto Hurtado [ 8 ]. In 1966, Cedric Bainton and I showed that Peruvian altiplano natives have much lower (than normal) peripheral chemoreceptor (carotid body) response to hypoxia [ 9 ]. We showed that CBF was not elevated in high-altitude natives in Bolivia and fell well below normal on oxygen [ 10 ]. With many others, we tried to find the mechanisms of high-altitude pulmonary and cerebral edema. Xu and I reported increased brain tissue vascular endothelial growth factor in acutely hypoxic rats, a possible cause of capillary leakage [ 11 ].extremephysiolmed.com ceaccp.oxfordjournals.org
