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To: Brumar89 who wrote (925621)3/11/2016 9:38:15 AM
From: Brumar89  Respond to of 1573305
 
Breakthrough curing blindness with NON-EMBRYONIC stem cells

Cure for cataracts: scientists use stem cells to grow 'living lens' in eye

Cataracts can be cured by regrowing the lens in the eye using stem cells, a breakthrough hailed as 'remarkable' by scientists

By Sarah Knapton, Science Editor

6:00PM GMT 09 Mar 2016

Cataracts can be cured by using a patient’s own stem cells to regrow a ‘living lens’ in their eye, restoring sight in just three months, scientists have shown.

In research described as ‘remarkable,’ surgeons reversed blindness in 12 infants born with congenital cataracts by removing the damaged lens and coaxing nearby cells to repair the damage.

“This is one of the finest achievements in the field of regenerative medicine until now"
Dr Dusko Ilic, King's College London

It could pave the way for millions of older people in Britain having their sight restored using their own cells.

Currently, cataracts are treated by inserting an artificial plastic lens into the eye, but that can lead to infections, inflammation and a night time halo effect in vision. For babies the risks from surgery are even greater because the eye is still developing.

But using the new technology scientists at the University of California, San Diego, showed that cataracts without the need for a transplant. They now plan to start work on age-related cataracts which occur when clumps of protein build up over time, creating a clouding effect.

The new technique would not requre an artifical lens Photo: Clara Molden/The Telegraph

"An ultimate goal of stem cell research is to turn on the regenerative potential of one's own stem cells for tissue and organ repair and disease therapy," said Dr Kang Zhang, chief of Ophthalmic Genetics and founding director of the Institute for Genomic Medicine at UC San Diego School of Medicine.

"The success of this work represents a new approach in how new human tissue or organ can be regenerated and human disease can be treated, and may have a broad impact on regenerative therapies by harnessing the regenerative power of our own body.

"We believe that our new approach will result in a paradigm shift in cataract surgery and may offer patients a safer and better treatment option in the future."

A diagram of the eye

Cataract surgery is now the most common surgical procedure undertaken in England with around 300,000 operations performed annually on the NHS. The procedure involves removing the clouded lens and inserting an artificial plastic version, called at intraocular lens.

But a large number of patients undergoing surgery are left with poor vision and still need to wear glasses for driving or reading a book.

The new technique removes the lens but leaves behind the lens capsule - a membrane that helps give the lens its required shape to function. Nearby regenerative stem cells are then moved to the membrane where they begin to grow into a new, fully functioning and transparent lens.

The procedure was carried out on 12 infants under the age of two who healed far more quickly and without complication compared with a group of 25 youngsters who had a traditional plastic lens fitted After three months, a clear, regenerated curved lens have developed in all of the trial patients' eyes. Nearly 300 babies are born with congential cataracts each year in Britain.

A patient undergoes testing ahead of a lens implant Photo: David Rose/The Telegraph

Dr Dusko Ilic, Reader in Stem Cell Science, King's College London, described the trial as a ‘remarkable accomplishment.’

“This is one of the finest achievements in the field of regenerative medicine until now,” said.

“The basic science research led to the hypothesis that preserving and stimulating stem cells in the eye might promote regeneration of a surgically removed lens.

“And indeed, their hypothesis was true. They proved it first by testing a new surgical approach in rabbits and primates before successfully treating 12 infants. It is science at its best.”

Prof Graham McGeown, Deputy Head of the School of Medicine, Dentistry & Biomedical Sciences, Queen's University Belfast, said the research could lead to ‘an important new treatment.’

“They showed that this new approach dramatically reduced the risk of sight damaging side effects when compared with the current ‘best practice’ treatment, which involves more destructive surgery followed by implantation of an artificial lens.”

In a separate study, scientist at Cardiff University and Osaka University in Japan showed that they could use stem cells to regenerate several types of tissue from the eye in one go.

When transplanted into a rabbit, the tissue was shown to reverse blindness, paving the way for human trials, which could see vision restored in people with a range of sight problems.

Professor Andrew Quantock, of Cardiff University, said: “This research shows that various types of human stem cells are able to take on the characteristics of the cornea, lens and retina.

“Importantly, it demonstrates that one cell type - the corneal epithelium - could be further grown in the lab and then transplanted on to a rabbit’s eye where it was functional, achieving recovered vision.”

Around 4000 corneal grafts are performed by the NHS annually, which rely on human organ donation.

Prof Julie Daniels, of UCL, said: "These two studies illustrate the remarkable regenerative and therapeutic potential of stem cells. Lens regeneration might also turn out to be possible in ageing adults."

Both studies were published in the journal Nature.

http://www.telegraph.co.uk/news/health/news/12189238/Scientists-use-stem-cells-to-grow-living-lens-in-eye-and-cure-cataracts.html



To: Brumar89 who wrote (925621)3/11/2016 9:40:16 AM
From: gronieel2  Respond to of 1573305
 
...This is changing opinions about abortion....

It sure is. You get more money for the larger ones.



To: Brumar89 who wrote (925621)3/11/2016 9:51:01 AM
From: TideGlider2 Recommendations

Recommended By
Brumar89
locogringo

  Respond to of 1573305
 
I wonder sometimes why people appear to champion a woman being ignorant of the other life within her.



To: Brumar89 who wrote (925621)3/12/2016 10:39:28 PM
From: 2MAR$  Read Replies (1) | Respond to of 1573305
 
What you said was dishonest diversion & pure nonsense, Barbara & Laura Bush were certainly aware of & had viewed ultrasounds of babies in the womb. Most probably Nancy Reagan as well. This did not change a core belief in pro-choice, once again every first lady since Jackie O has been pro choice, Pat Nixon, Nancy Reagan thru Laura Bush.





To: Brumar89 who wrote (925621)3/12/2016 10:48:52 PM
From: 2MAR$2 Recommendations

Recommended By
loantech
rzborusa

  Read Replies (2) | Respond to of 1573305
 
When women can see their unborn children they can see they are babies.This is changing opinions about abortion.

Women who view their unborn via ultrasound at such advanced stages of pregnancy, 99% are not intending to choose abortion in the first place. What you're saying is rubbish, mainly because you're assuming you know what women think & secondly most women already dislike abortion which is why contraceptive use is always so emphasized.

Now imagine human religion that forbids contraception or family planning, think you can? I can name two, both Abrahamic, one has Rome as the capital the other Mecca. Are you really ready for Mexico's population doubling in 2030/35? Irans? But why ask these questions of you, where the answer is sure to be another lie but the human reality is assured. Your lying to yourself is the problem, fantasy worlds vs real world.