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Biotech / Medical : Zonagen (zona) - good buy? -- Ignore unavailable to you. Want to Upgrade?

To: Dauntless who wrote (1440)	12/31/1997 8:58:00 PM
From: Bill Wexler	Respond to of 7041

Zonagen lie #1: This gem was written by Claud B - Ferrari pilot: Message 850205 it is interesting to note that when Claud "My other car is a Ferrari" B wrote this lie, he probably knew full well that in actuallity it was Zonagen's ancient generic drug that was used to treat hypertensives. rxmed.com Here is a short article about Viagra. You may also do a web search under the keyword "Viagra". thepillbox.com

To: Dauntless who wrote (1440)	12/31/1997 9:00:00 PM
From: Bill Wexler	Respond to of 7041

Zonagen lie #2; Dr. Irwin Goldstein is a reputable consultant: abcnews.com

To: Dauntless who wrote (1440)	12/31/1997 9:00:00 PM
From: Bill Wexler	Respond to of 7041

Zonagen lie #3: Bruce Rosen states the following: <<They have a unique formulation of phentolamine called Vasomax..>> Zonagen's drug is phentolamine mesylate. It is not unique. fda.gov Do a search for the word "phentolamine" or "regitine".

To: Dauntless who wrote (1440)	12/31/1997 9:04:00 PM
From: Bill Wexler	Respond to of 7041

Zonagen lie #4: Why would anyone accuse a fine, upstanding corporate citizen like Zonagen of trying to mislead investors? I mean, take a look at this straightforward and honest press release: pslgroup.com I draw the reader's attention to the first paragraph: ---------------------- THE WOODLANDS, Texas, June 24, 1996 -- Zonagen, Inc. (NASDAQ:ZONA, Pacific ZNG) announced today that it has received notification from the United States Patent and Trademark Office that the patent covering the use of VASOMAX(TM) as a treatment for erectile dysfunction (impotency) has been allowed... ----------------------- Oh...and just for grins, Joe Podolski weighs in with a cautious projection for the NDA filing date: --------------------- .....We believe that we will be able to submit our VASOMAX(TM) NDA to the FDA in June of 1997." ------------------------- Message 2985680

To: Dauntless who wrote (1440)	12/31/1997 9:12:00 PM
From: Bill Wexler	Respond to of 7041

Zonagen lie #5: In another press release, Zonagen bravely stands by its claim that it has received a patent for the Vasomax formulation: pslgroup.com ------------------------------ ...Zonagen has received a domestic patent and has filed international patent applications on the Vasomax formulation.... ------------------------------ Message 2986102

To: Dauntless who wrote (1440)	12/31/1997 9:14:00 PM
From: Bill Wexler	Respond to of 7041

Zonagen lie #6: Well, perhaps the word "lie" is a tad too harsh...how about "omission" or "misleading statement". I direct the reader to - again - read the first paragraph of the following press release very carefully: pslgroup.com ---------------------- THE WOODLANDS, Texas, June 24, 1996 -- Zonagen, Inc. (NASDAQ:ZONA, Pacific ZNG) announced today that it has received notification from the United States Patent and Trademark Office that the patent covering the use of VASOMAX(TM) as a treatment for erectile dysfunction (impotency) has been allowed... ----------------------- I think it would be fair to say that when Joe investor receives a phone call from a certain Texas "financial advisor" with a pitch to buy this fine, young company...and then the advisor sends him some promotional literature that includes the aforementioned press release, then Joe investor might...just might...get the impression that Zonagen developed a brand new drug and through its own efforts filed a new patent application which was subsequently approved. After all, Joe investor can be confident that this certain Texas "financial advisor" has Joe's best interst in mind. Now if only Joe investor took a little time to actually dig up the patent and read the title page: patent.womplex.ibm.com Joe then scratches his head and says, "Hey wait a minute, this patent was filed 3 years ago by some Zorgnioti guy, doesn't cover the Vasomax formulation, and Zonagen is only the assignee! Imagine that!" With a little bit more digging, Joe would have found out that the patent was paid for in stock (at much lower prices than Joe is paying). Joe would also be astonished to learn that the certain Texas "financial advisor" in our story also was paid with some cut-rate stock. What a coincidence.

To: Dauntless who wrote (1440)	12/31/1997 9:16:00 PM
From: Bill Wexler	Read Replies (1) \| Respond to of 7041

Zonagen lie #7: Phentolamine is a dandy way to treat ED...right? Well...sort of....maybe. Certain drugs in combination with Phentolamine when injected directly into the penis has shown promise in some studies. It is very important to note that the FDA has not approved Phentolamine for this purpose.. Now let's ask a reasonable quesion: If there is absolutely no evidence that Phentolamine - a vasodilator - works by itself when injected into the penis, and it is not approved for this purpose... ...then why would it work orally? And I'll point out yet one more time that Zonagen's own patent - the patent they purchased that covers the administration of the drug by any means except oral - opines that it is very poor method. And now you understand exactly why Zonagen has obfuscated the results of Phase II and Phase III trials. search.cybermedical.com