To: epicure who wrote (63524 ) 3/30/2018 10:08:54 PM From: koan Respond to I am sure i-node knew all of that off the top of his head and was what her was referring to :)>, nature.com p -value range, as seen in the Manhattan plot (Fig. 1 ), though no SNP reached genome-wide significance (5?×?10-8). The most prominent of these regions were on chromosomes 13 (minimum p ?=?7.5?×?10-7, rs9547443) and 14 (p ?=?4.7?×?10-7, rs1035144), where some SNPs had 10-7?<?p ?<?10-6 (each region with 9 to 10 SNPs with p ?<?10-5, Table S1 ). There are a number of genes of relevance to the trait in and around these regions, which we describe below. We further note that the most significant SNP (rs77013977, p ?=?7.1?×?10-8) in the 23andMe male GWAS 29 was nominally associated (p ?=?4.1?×?10-3) in our own GWAS. We used a meta-analytic statistic that did not need direction of effect, Fisher’s combined probability test 30 , which yielded p ?=?6.7?×?10-9 for this SNP, which is the first reported genome-wide significant association for the trait. As previously noted 29 , rs77013977 is an intronic SNP in NKAIN3 , which is one of a family of four proteins (NKAIN1–4) suggested to be critical for neuronal function 31 ."30 , which yielded p ?=?6.7?×?10-9 for this SNP, which is the first reported genome-wide significant association for the trait. As previously noted 29 , rs77013977 is an intronic SNP in NKAIN3 , which is one of a family of four proteins (NKAIN1–4) suggested to be critical for neuronal function 31 ."
