SI
SI
discoversearch

We've detected that you're using an ad content blocking browser plug-in or feature. Ads provide a critical source of revenue to the continued operation of Silicon Investor.  We ask that you disable ad blocking while on Silicon Investor in the best interests of our community.  If you are not using an ad blocker but are still receiving this message, make sure your browser's tracking protection is set to the 'standard' level.
Pastimes : Diabetic Kitchen -- Ignore unavailable to you. Want to Upgrade?


To: voop who wrote (394)4/29/2018 7:09:38 AM
From: Pogeu Mahone  Respond to of 1096
 
Who would study D3? Can anyone make money with D3? Is medicine a science?

Do you know 60% of FDA approved drugs cannot do a reproducible study!

Link copied…

HEALTH CARE
Scientists' Elusive Goal: Reproducing Study Results

By
Gautam Naik

December 2, 2011

Two years ago, a group of Boston researchers published a study describing how they had destroyed cancer tumors by targeting a protein called STK33. Scientists at biotechnology firm Amgen Inc. quickly pounced on the idea and assigned two dozen researchers to try to repeat the experiment with a goal of turning the findings into a drug.

It proved to be a waste of time and money. After six months of intensive lab work, Amgen found it couldn't replicate the results and scrapped the project.
...



Carry On:O)

Kindle Price:$3.99Save $6.00 (60%)



kindle unlimited logo
Unlimited reading. Over 1 million titles. Learn more

Read for Free
OR
<input id="one-click-button" name="submit.one-click-order.x" class="a-button-input" type="submit" value="Buy now with 1-Click ®" aria-labelledby="checkoutButtonId-announce" style="margin: 0px; font-size: 13px; vertical-align: middle; line-height: 19px; font-family: inherit; transition: all 0.1s linear; position: absolute; border-width: 0px; border-style: initial; border-color: initial; cursor: pointer; height: 29px; width: 238px; left: 0px; top: 0px; opacity: 0.01; outline: 0px; overflow: visible; z-index: 20; -webkit-appearance: button;">Buy now with 1-Click ®

Deliver to your Kindle or other device

Send a free sample

Deliver to your Kindle or other device

Give as a Gift

<div id="add-to-wishlist-button-group" data-hover=" To Add to Your List, choose from options to the left" class="a-button-group a-declarative a-spacing-none" data-action="a-button-group" role="radiogroup" style="box-sizing: border-box; margin-bottom: 0px !important; display: table; font-size: 0px; line-height: 0; outline: 0px; position: relative; white-space: nowrap; width: 234px;"><input id="add-to-wishlist-button-submit" name="submit.add-to-registry.wishlist" title="Add to List" data-action="atwl-splitbutton-main" data-hover=" To Add to Your List, choose from options to the left" class="a-button-input a-declarative" type="submit" aria-labelledby="wishListMainButton-announce" style="margin: 0px; font-size: 0px; vertical-align: middle; line-height: 19px; font-family: inherit; transition: all 0.1s linear; position: absolute; border-width: 0px; border-style: initial; border-color: initial; cursor: pointer; height: 29px; width: 232px; left: 0px; top: 0px; opacity: 0.01; outline: 0px; overflow: visible; z-index: 20; -webkit-appearance: button;">Add to List

Enter a promotion code or Gift Card

Share Facebook Twitter Pinterest <Embed>

Ad feedback






To: voop who wrote (394)4/29/2018 7:22:29 AM
From: Pogeu Mahone  Respond to of 1096
 
Here is what happens to independent thinkers in Medicine in real life:

The FDA and our gov't is not watching out for us
but their own conceived prejudices .

==============================
At 89, legendary psychiatrist and marijuana advocate still wonders about Harvard professorship
7
KEITH BEDFORD/GLOBE STAFF
Dr. Lester Grinspoon, the author of "Marijuana Reconsidered," sits in his home in Auburndale, MA.

By Dan Adams GLOBE STAFF APRIL 28, 2018
For more stories on marijuana, subscribe to our newsletter, This Week in Weed.

“I want a goddamn strong statement on marijuana,” the distinctive voice on the tape growls. “I mean, one on marijuana that just tears the ass out of them.”

It was May 1971, and Richard Nixon was fuming over a review included in his morning news summary of the book “Marihuana Reconsidered,” in which 42-year-old Harvard Medical School psychiatrist Lester Grinspoon savaged the US government’s case for keeping cannabis illegal.

The book was immediately popular — The New York Times called it “The best dope on pot so far” — and the author’s Ivy League pedigree made it hard to dismiss as a hippie screed. But it also raised hackles at Harvard (more on that in a moment) and, plainly, in the White House.

ADVERTISEMENT

“Every one of the bastards that are out for legalizing marijuana is Jewish,” Nixon ranted in a conversation captured by the Oval Office recording system. “What the Christ is the matter with the Jews? . . . I suppose it’s because most of them are psychiatrists.”

Get Fast Forward in your inbox:
Forget yesterday's news. Get what you need today in this early-morning email.

Sign Up

Nixon had circled Grinspoon’s name on the review, writing, “this clown is far on the left.”

Now 89, Grinspoon hadn’t known of the Nixon barb until recently.

“Imagine that,” he said, laughing uproariously. “I got the attention of one of the world’s biggest [jerks]. It’s a red badge of courage.”

Snubbed, twiceA psychiatrist, Vietnam War opponent, and son of a Russian Jew, Grinspoon made a rich target for Nixon. But the book also earned him critics at Harvard Medical School, where colleagues greeted the pro-pot tome skeptically. Though more muted than Nixon’s ravings, their disapproval ultimately had more influence on his career.

ADVERTISEMENT

Grinspoon says he was twice denied a promotion to full professor, once in 1975 and again in 1997, despite a career that included pioneering research on schizophrenia, dozens of books and papers, and leadership roles at the Massachusetts Mental Health Center and other prestigious institutions. He retired in 2000 as an associate professor.

The school never offered him an official explanation, but his allies believe an undercurrent of unscientific prejudice against cannabis among faculty and school leaders doomed his chances; Grinspoon remembers a dean telling him in 1975 the promotions committee “hated” his book because it was “too controversial.”


KEITH BEDFORD/GLOBE STAFF
Dr. Lester Grinspoon holds a can of marijuana in his home in Auburndale, MA.
Today, Grinspoon’s controversial vision — legal marijuana — is the law in nine states, including Massachusetts. And now, his friends and sympathetic former colleagues say, it’s Harvard’s turn. They have mounted a campaign to get the medical school to award Grinspoon a symbolic full professorship, arguing the honor is more than merited by his academic work — not to mention his pivotal role in the movement to legalize marijuana.

“He bore the academic torch through the dark years of the drug war when it was heresy to speak the truth about marijuana,” said attorney Dick Evans, a cannabis advocate who has worked with Grinspoon since the early 1980s.

Recognizing Grinspoon now, Evans added, “would not only be an act of supreme decency, but also an act of institutional humility — and I think Harvard’s capable of both.”

‘Too controversial’

ADVERTISEMENT

Raised in Brookline, Grinspoon joined the Harvard faculty after receiving his medical degree from the school. In the 1950s, he was among the first American doctors to prescribe lithium for bipolar disorder; he later coauthored a book on schizophrenia and cofounded the well-known Harvard Mental Health Letter.

He was something of a campus renegade, speaking out against the Vietnam War. He ran for president of the American Psychiatric Association as head of a liberal faction that thought the group was obligated by professional ethics to oppose the conflict.

His antiwar activism led Grinspoon to befriend another progressive on campus: Carl Sagan.

Sagan, who would later become perhaps the most popular scientist in the United States as the host of television shows such as “Cosmos,” was a prolific but closeted pot-smoker. Writing under the pseudonym “Mr. X,” Sagan said pot enhanced his creative thinking and advanced his scientific work.

In the ’60s, though, Grinspoon was shocked.

“When I saw him smoking for the first time, I said, ‘Carl, you musn’t do that! That’s a very dangerous drug,’?” Grinspoon recalled. “He took another puff and said, ‘Here, Lester, have some, you’ll love it and it’s harmless.’ I was absolutely astonished.”

Grinspoon stormed off to the medical school library to prove Sagan wrong. Instead, he found his assumptions about the drug had little basis.


JOE DENNEHY/GLOBE STAFF
Dr. Lester Grinspoon spoke during a drug hearing at the Massachusetts State House in Boston, March 9, 1971.
“I have concluded,” Grinspoon would later write, “that marijuana is a relatively safe intoxicant which is not addicting, does not in and of itself lead to the use of harder drugs, is not criminogenic, and does not lead to sexual excess.” The real harm, he added, was “the way we as a society were dealing with people who use it,” referring to the incarceration of marijuana users.

Thus began an obsession with the subject that ultimately resulted in “Marihuana Reconsidered,” a blend of literature review and cultural critique rendered in crisp, explanatory prose. The book went through several printings and earned Grinspoon numerous appearances in the media and before lawmakers.

Ironically, Grinspoon came to his conclusions without having, at the time, tried marijuana. He reasoned his credibility would be undermined if he was labeled a “dope-smoker.” He would first try it two years later, around the time he was also administering marijuana to his young son, who was dying of cancer. Eventually, he came out publicly, hoping it would help dispel stoner stereotypes.

“I have and I do smoke marijuana,” Grinspoon said during an appearance on the “Today Show” in 1973, a moment he said was “jaw-dropping” for host Barbara Walters.

Two years later, Grinspoon was rejected for a full professorship. The promotions committee “loved the schizophrenia book, but they hated ‘Marihuana Reconsidered,’ ” he recalls his boss telling him. “‘They said it was too controversial.’”

“I was crushed,” Grinspoon said. “I don’t give a damn now, but it hurt terribly at the time.”

Harvard may have had its reasons. The previous decade, Timothy Leary had embarrassed the school with his questionable research into hallucinogens, often carried out while under their influence. After being dismissed in 1963, he went on to become a counterculture icon.

But Grinspoon was no Timothy Leary. He was an earnest academic who wore a tie, and insisted he never promoted the use of marijuana, but rather the elimination of draconian prohibitions. That distinction was lost on many.

“There always was a feeling that his interest in marijuana was a little out of the way compared to his colleagues,” recalled James Bakalar, Grinspoon’s longtime coauthor and collaborator. “They regarded it as eccentric. It wasn’t ‘mainstream psychiatry.’ ”

Grinspoon would go on to help revive the National Organization for the Reform of Marijuana Laws after its disastrous brush with the Carter administration. He also authored another book on marijuana, and in 1997 even quit Harvard’s addiction-studies program to protest the school’s bestowal of an award on Bill Clinton’s antidrug policy adviser.

After retiring, Grinspoon launched a website where he published occasional reflections on marijuana and his career.

“He’s one of the most important people in the history of marijuana reform,” said Rick Cusack, a former associate publisher of High Times, who was the first to link Nixon’s recorded rant with the publication of “Marihuana Reconsidered.” “His book started the movement.”

Still unrecognizedWhile praising Grinspoon’s work, a Harvard Medical School spokeswoman said the school’s policy “doesn’t allow us to retroactively grant a professorship or any other appointment.”

Several former colleagues backed Harvard, saying full professorships go to candidates who conduct the kind of hard-core science that attracts federal grants. Grinspoon, they said, did little hands-on research, but rather synthesized the work of others.

“You have to have very good, empirical research work, not hearsay,” said Dr. Ming Tsuang, Grinspoon’s chief in the 1990s.

His supporters say this is a blinkered view, arguing Grinspoon conducted work at significant professional risk and helped to inspire new research into medical uses of cannabis. They said Grinspoon helped redefine the relationship between academia and advocacy.

Grinspoon has long blamed former Harvard psychiatry chairman Dr. Joseph Coyle for vetoing his promotion in 1997. Coyle disputes that account, saying a committee of Grinspoon’s peers declined to back him because of a lack of original research.

Still, Coyle acknowledged in an interview that the thinking at the time on marijuana “could have been an element.” While he stopped short of endorsing a full professorship now, Coyle said Harvard could at least go over the matter with Grinspoon.

Supporters also argue that the seeds Grinspoon planted decades ago are only now germinating, with support for legalization recently topping 60 percent in Massachusetts, and pot retailers soon to open for business.

“I wouldn’t be a state marijuana regulator if people like Dr. Grinspoon hadn’t made sacrifices,” said Shaleen Title, one of the five commissioners leading the Massachusetts Cannabis Control Commission. “Harvard should recognize that he was right all along.”


KEITH BEDFORD/GLOBE STAFF
Copies of Dr. Lester Grinspoon's book "Marijuana Reconsidered" sit on a shelf in his home in Auburndale, MA.
But if Grinspoon’s views on marijuana have been, for many, vindicated, and Nixon, for almost everyone, discredited, Harvard Medical School’s role in the drama of Grinspoon’s life is more complex. Despite declining to promote him, it was his professional home for decades. In fact, he supports the campaign to make him a professor mainly out of affection for Harvard.

“Institutions that can acknowledge they’ve made a mistake are always doing something noble,” he said.

Today, Grinspoon lives in a Newton retirement community with his wife, Betsy. His health is declining, but his personality — warm and quick to laugh, with instinctive compassion for the vulnerable but little patience for those he deems fools — hasn’t faded. That’s probably why at the dusk of his life, Grinspoon still finds himself fighting the same old war.

During a recent dinner with friends that concluded with a joint, Grinspoon recounted his attempts to get elderly neighbors to smoke with him and impishly confessed to trying to grow a marijuana plant in the courtyard of the senior living complex.

“It had been there about three weeks, growing nicely, and I came back and somebody cut it down! Who would do that?” Grinspoon said. “That’s all going to change. It’s changing so rapidly I can scarcely believe it.”

DOCUMENT
TEXT

Zoom




To: voop who wrote (394)4/29/2018 8:22:34 AM
From: Pogeu Mahone  Respond to of 1096
 
Linus Pauling makes a Total ASS of himself!!!!

Carry on!
==========================================

Work on quasicrystals[ edit]



Shechtman's Nobel Prize–winning work was in the area of quasicrystals, ordered crystalline materials lacking repeating structures, such as this Al-Pd-Mn alloy. [14]

<div id="mwe_player_0" class="PopUpMediaTransform" videopayload="

" style="position: relative; margin: 0px auto; width: 220px;">

Interview with Dan Shechtman after his Nobel lecture

From the day Shechtman published his findings on quasicrystals in 1984 to the day Linus Pauling died (1994), Shechtman experienced hostility from him toward the non-periodic interpretation. "For a long time it was me against the world," he said. "I was a subject of ridicule and lectures about the basics of crystallography. The leader of the opposition to my findings was the two-time Nobel Laureate Linus Pauling, the idol of the American Chemical Society and one of the most famous scientists in the world. For years, 'til his last day, he fought against quasi-periodicity in crystals. He was wrong, and after a while, I enjoyed every moment of this scientific battle, knowing that he was wrong."[ citation needed]

Linus Pauling is noted saying "There is no such thing as quasicrystals, only quasi-scientists." [15] Pauling was apparently unaware of a paper in 1981 by H. Kleinert and K. Maki which had pointed out the possibility of a non-periodic Icosahedral Phase in quasicrystals [16] (see the historical notes). The head of Shechtman's research group told him to "go back and read the textbook" and a couple of days later "asked him to leave for 'bringing disgrace' on the team." [17] Shechtman felt dejected. [15] On publication of his paper, other scientists began to confirm and accept empirical findings of the existence of quasicrystals. [18] [19]


The Nobel Committee at the Royal Swedish Academy of Sciences said that "his discovery was extremely controversial," but that his work "eventually forced scientists to reconsider their conception of the very nature of matter." [15] Through Shechtman's discovery, several other groups were able to form similar quasicrystals,[ when?] finding these materials to have low thermal and electrical conductivity, while possessing high structural stability.[ citation needed] Quasicrystals have also been found naturally.

A quasiperiodic crystal, or, in short, quasicrystal, is a structure that is ordered but not periodic. A quasicrystalline pattern can continuously fill all available space, but it lacks translational symmetry. [20] "Aperiodic mosaics, such as those found in the medieval Islamic mosaics of the Alhambra palace in Spain and the Darb-i Imam shrine in Iran, have helped scientists understand what quasicrystals look like at the atomic level. In those mosaics, as in quasicrystals, the patterns are regular -- they follow mathematical rules -- but they never repeat themselves." [15]"An intriguing feature of such patterns, [which are] also found in Arab mosaics, is that the mathematical constant known as the Greek letter tau [ sic], or the " golden ratio", occurs over and over aga



To: voop who wrote (394)4/29/2018 9:39:50 AM
From: Pogeu Mahone  Respond to of 1096
 
What doctors do not know another example:

Meet Your 'Interstitium,' A Newfound Organ
By Rachael Rettner, Senior Writer | March 27, 2018 06:55am ET






Scientists discovered the new organ, which consists of fluid-filled spaces, in the body's connective tissue, including in the skin's dermis, which is shown above as the light pink layer at the bottom of this image.
Credit: Eric V. Grave/Getty

With all that's known about human anatomy, you wouldn't expect doctors to discover a new body part in this day and age. But now, researchers say they've done just that: They've found a network of fluid-filled spaces in tissue that hadn't been seen before.
These fluid-filled spaces were discovered in connective tissues all over the body, including below the skin's surface; lining the digestive tract, lungs and urinary systems; and surrounding muscles, according to a new study detailing the findings, published today (March 27) in the journal Scientific Reports.
Previously, researchers had thought these tissue layers were a dense "wall" of collagen — a strong structural protein found in connective tissue. But the new finding reveals that, rather than a "wall," this tissue is more like an "open, fluid-filled highway," said co-senior study author Dr. Neil Theise, a professor of pathology at New York University Langone School of Medicine. The tissue contains interconnected, fluid-filled spaces that are supported by a lattice of thick collagen "bundles," Theise said. [ 11 Body Parts Grown in the Lab]

The researchers said these fluid-filled spaces had been missed for decades because they don't show up on the standard microscopic slidesthat researchers use to peer into the cellular world. When scientists prepare tissue samples for these slides, they treat the samples with chemicals, cut them into thin slices and dye them to highlight key features. But this fixing process drains away fluid and causes the newfound fluid-filled spaces to collapse.

An image of the interstitium beneath the top layer of skin. Researchers say the organ is a body-wide network of interconnected, fluid-filled spaces supported by a lattice of strong, flexible proteins.
Credit: Illustration by Jill Gregory. Printed with permission from Mount Sinai Health System, licensed under CC-BY-ND.
Rather than using such slides, the researchers discovered these fluid-filled spaces by using a new imaging technique that allows them to examine living tissues on a microscopic level.
The researchers are calling this network of fluid-filled spaces an organ — the interstitium. However, this is an unofficial distinction; for a body part to officially become an organ, a consensus would need to develop around the idea as more researchers study it, Theise told Live Science. The presence of these fluid-filled spaces should also be confirmed by other groups, he added.
Official designation aside, the findings may have implications for a variety of fields of medicine, including cancer research, Theise said. For example, the findings appear to explain why cancer tumors that invade this layer of tissue can spread to the lymph nodes. According to the researchers, this occurs because these fluid-filled spaces are a source of a fluid called lymph and drain into the lymphatic system. (Lymph is a fluid that contains infection-fighting white blood cells.)
A new organ?
The human body is about 60 percent water. About two-thirds of that water is found inside cells, but the other third is outside cells and is known as "interstitial" fluid. Although researchers already knew that there is fluid between individual cells, the idea of a larger, connected interstitium — in which there are fluid-filled spaces within tissues — had been described only vaguely in the literature, Theise said. The new study, he said, expands the concept of the interstitium by showing these structured, fluid-filled spaces within tissues, and is the first to define the interstitium as an organ in and of itself.
The new work is based on the use of a relatively new technology called a "probe-based confocal laser endomicroscopy" or pCLE. This tool combines an endoscope with a laser and sensors that analyze reflected fluorescent patterns and gives researchers a microscopic view of living tissues.
Back in 2015, two of the study authors — Dr. David Carr-Locke and Dr. Petros Benias, both of whom were at Mount Sinai-Beth Israel Medical Center in New York City at the time — were using this technology when they saw something unusual while examining a patient's bile duct for cancer spread. They spotted a series of interconnected cavities in the tissue layer that didn't match any known anatomy, according to the report. When a pathologist made slides out of this tissue, the cavities disappeared — a mystery that was later found to be a consequence of the slide-making process.
In the new study, the researchers first used pCLE on cancer patients who were undergoing surgery to remove the pancreas and the bile duct. The imaging technique indeed showed the fluid-filled spaces in the connective tissue. When the tissue samples were removed from the body, they were quickly frozen, which allowed the fluid-filled spaces to stay open so the researchers could see them under a microscope.
Later, the researchers saw these same fluid-filled spaces in other samples of connective tissue taken from other parts of the body, in people without cancer, Theise said. "The more tissues I saw, the more I realized it's everywhere," he said.
The researchers think that the fluid-filled spaces may act as shock absorbers to protect tissues during daily functions, the researchers said.
Theise noted that there may be quite a bit of information already known about this fluid-filled space; it's just that researchers "didn't know what they were looking at." Indeed, the researchers plan to conduct a review of the scientific literature "for all the things we know about this [body part] but didn't know we knew it," Theise said.
Original article on Live Science.



To: voop who wrote (394)4/29/2018 9:51:14 AM
From: Pogeu Mahone  Respond to of 1096
 
In 1999, Dr. Reinhold Vieth, perhaps the world's leading expert on vitamin D toxicity and metabolism, wrote a systematic and scholarly review of the world's literature debunking the hysteria surrounding fears of vitamin D toxicity.

In a reply to critics of his paper, Vieth challenged anyone in the scientific community to present even a single case of vitamin D toxicity in adults from ingestion of up to 1,000 ug (40,000 IU) a day of cholecalciferol saying, "I welcome any discussion of evidence of harm with vitamin D3 (not D2) in adults at doses <1,000 ug/d." Vieth's challenge remains unanswered and his work remains unrefuted."


Here is a reading list if interested:

Doctor Advocates:
Dr. Reinhold Vieth google.com

Dr. William Davis google.com

Dr. Michael Holick google.com



To: voop who wrote (394)4/29/2018 10:13:07 AM
From: Pogeu Mahone1 Recommendation

Recommended By
toccodolce

  Read Replies (1) | Respond to of 1096
 
One of the world's foremost authorities on vitamin d metabolism and physiology recently said, "worrying about vitamin d toxicity is like worrying about drowning when you are dying of thirst."


This guy is pissed: Watch all of it the last 5 minutes he calls the health care industry out:


https://www.youtube.com/watch?v=



To: voop who wrote (394)4/29/2018 10:39:21 AM
From: goldworldnet  Read Replies (1) | Respond to of 1096
 
Below is an excerpt.



ncbi.nlm.nih.gov

Josh

* * *



To: voop who wrote (394)4/29/2018 10:49:41 AM
From: Pogeu Mahone  Respond to of 1096
 
One more
Does your doctor or any doctor

know about

the new lymphatic chart? the answer is NO

On the right is your autoimmune system diagrammed.

I was at 3 hospitals this week in Boston and asked this question

Not one health professional doctor, nurse, PT, OT, etc has heard of this new lymphatic chart!

As to how the brain’s lymphatic vessels managed to escape notice all this time, Kipnis described them as “very well hidden” and noted that they follow a major blood vessel down into the sinuses, an area difficult to image. “It’s so close to the blood vessel, you just miss it,” he said. “If you don’t know what you’re after, you just miss it.”
“Live imaging of these vessels was crucial to demonstrate their function, and it would not be possible without collaboration with Tajie Harris,” Kipnis noted. Harris, a PhD, is an assistant professor of neuroscience and a member of the BIG center. Kipnis also saluted the “phenomenal” surgical skills of Igor Smirnov, a research associate in the Kipnis lab whose work was critical to the imaging success of the study.


=======================

Home

new lymphatic system map
NEUROSCIENCE NEWSJUNE 1, 2015
0 MIN READ



Maps of the lymphatic system: old (left) and updated to reflect UVA’s discovery. Image credit: University of Virginia Health System.