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To: Biotech Jim who wrote (658)	9/14/2018 3:47:29 PM
From: DewDiligence_on_SI	Read Replies (1) \| Respond to of 668

I would think someone's track record at identifying biotech scams would also be relevant.

To: Biotech Jim who wrote (658)	9/14/2018 11:35:25 PM
From: Robohogs	Respond to of 668

Only if folks were willing to tell everyone. Polls are blind. I will think about a list of questions. There is probably a way to do a google form. I will ask my kids lol. I listened to MS. The one big takeway I had was it sounded smoother. I would say both calls were very professionally handled. Not much detail, but is there ever? Furthermore, he point blank acknowledged that using enzymes, etc. would change their ability to use the 361 path so the shorts just say that they do not meet criteria. Well let’s listen to what he must be saying. He point blank says they with their experts (icludes lawyers, Ex officials) believe they meet the criteria. That at some point, if this is a fraud, comes out and proves the lie. I cannot fathom why a guy and team with these professional quals would do this. The SEC and DOJ would ruin their lives. Ok maybe you get 2 years of fun but your life is ruined and running a com-any under attack is not fun. So, if you take the statements at face value they are not doing anything super complex. They talked about scaling manufacturing at MS too. Costs appeared extremely negligible and easy to do everywhere. Add to that the low $ needed for R&D and the ease if transfer to other systems. That tells me there must be some kind of molecular switch these guys found and the secrecy is needed. OR, the whole thing IS an intricate fraud. In some ways, it is the simplest answer. But friends have talked to docs and the evidence seems to say rather strongly it works at some big level. All very confusing tbh. Jon

To: Biotech Jim who wrote (658)	9/17/2018 1:26:07 PM
From: Biotech Jim	Read Replies (1) \| Respond to of 668

I do know there is some patent rejection controversy with COOL, but patents do get rejected quite freqently and need refiling for whatever reason. I hold a bunch of patents, fwiw, US and ex US. In my limited DD on COOL, I did read this patent. freshpatents.com Methods for development and use of minimally polarized function cell micro-aggregate units in tissue applications using lgr4, lgr5, and lgr6 expressing epithelial stem cells Provided herein are constructs of micro-aggregate multicellular, minimally polarized grafts containing Leucine-rich repeat-containing G-protein coupled Receptor (LGR) expressing cells for wound therapy applications, tissue engineering, cell therapy applications, regenerative medicine applications, medical/therapeutic applications, tissue healing applications, immune therapy applications, and tissue transplant therapy applications which preferably are associated with a delivery vector/substrate/support/scaffold for direct application. There is a related publication in the peer reviewed literature on this topic as well. These LGR receptors are interesting such proteins, in my view, and I am a (former) G-protein coupled receptor biogeek and have published on at least 8 GPCRs. I think there may be something key in this patent for the cellular workings of the skin cells and their development. But patents are limited in the information they give, and the levels of relevant products from the conditioned media. LGR GPCRs have cousins in the gonadotropin receptors and related cellular 'trophic' and 'tropic' such receptors. I can see, using my expertise, that there is some interesting stuff here. One key to me is how much such 'stuff' is patented, and how much is trade secret, and how much is hope?