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Biotech / Medical : momo-T/FIF -- Ignore unavailable to you. Want to Upgrade?

To: tuck who wrote (11686)	9/21/2018 6:40:46 PM
From: Miljenko Zuanic	Read Replies (2) \| Respond to of 12215

Tuck, this was peptide, fairly large ( pdfaiw.uspto.gov ), drawing p14 what route they are using, also dose range in P1? Stability? P1 safety will not bring them partner, IMO.

To: tuck who wrote (11686)	9/21/2018 7:10:09 PM
From: scaram(o)uche	Respond to of 12215

You've seen this, correct? Free Radic Biol Med. 2016 Nov;100:182-187. doi: 10.1016/j.freeradbiomed.2016.05.015. Epub 2016 May 20. MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism. Lee C1, Kim KH2, Cohen P3. 1 USC Leonard Davis School of Gerontology, 3715 McClintock Ave., Suite 103, Los Angeles, CA 90089, United States. Electronic address: changhan.lee@usc.edu. 2 USC Leonard Davis School of Gerontology, 3715 McClintock Ave., Suite 103, Los Angeles, CA 90089, United States. 3 USC Leonard Davis School of Gerontology, 3715 McClintock Ave., Suite 103, Los Angeles, CA 90089, United States. Electronic address: hassy@usc.edu. Mitochondria are ancient organelles that are thought to have emerged from once free-living a-proto-bacteria. As such, they still possess several bacterial-like qualities, including a semi-autonomous genetic system, complete with an independent genome and a unique genetic code. The bacterial-like circular mitochondrial DNA (mtDNA) has been described to encode 37 genes, including 22 tRNAs, 2 rRNAs, and 13 mRNAs. Two additional peptides reported to originate from the mtDNA, namely humanin (Hashimoto et al., 2001; Ikone et al., 2003; Guo et al., 2003) [1-3] and MOTS-c (mitochondrial ORF of the twelve S c) (Lee et al., 2015) [4], indicate a larger mitochondrial genetic repertoire (Shokolenko and Alexeyev, 2015) [5]. These mitochondrial-derived peptides (MDPs) have profound and distinct biological activities and provide a paradigm-shifting concept of active mitochondrial-encoded signals that act at the cellular and organismal level (i.e. mitochondrial hormone) (da Cunha et al., 2015; Quiros et al., 2016) [6,7]. Considering that mitochondria are the single most important metabolic organelle, it is not surprising that these MDPs have metabolic actions. MOTS-c has been shown to target the skeletal muscle and enhance glucose metabolism. As such, MOTS-c has implications in the regulation of obesity, diabetes, exercise, and longevity, representing an entirely novel mitochondrial signaling mechanism to regulate metabolism within and between cells. Price:book of ~ 8?? The power of merely mentioning nash, or ??? Every reference, search term "MOTS-c".... ncbi.nlm.nih.gov

To: tuck who wrote (11686)	9/21/2018 7:14:42 PM
From: scaram(o)uche	Respond to of 12215

From one of their old PRs..... >> MENLO PARK, Calif.--(BUSINESS WIRE)-- CohBar, Inc. (TSX-V: COB.U), an innovative biotechnology company focused on developing mitochondria-based therapeutics to treat diseases associated with aging, today provided a corporate update and reported financial results for the full year ending December 31, 2014. << Humble beginnings.