SI
SI
discoversearch

We've detected that you're using an ad content blocking browser plug-in or feature. Ads provide a critical source of revenue to the continued operation of Silicon Investor.  We ask that you disable ad blocking while on Silicon Investor in the best interests of our community.  If you are not using an ad blocker but are still receiving this message, make sure your browser's tracking protection is set to the 'standard' level.
Biotech / Medical : momo-T/FIF -- Ignore unavailable to you. Want to Upgrade?


To: tuck who wrote (11713)10/2/2018 12:31:19 AM
From: scaram(o)uche  Respond to of 12215
 
>> efficacy drops off after treatment <<

Yes, the chances of that were 100%. Not 99%. Not some undefined percentage. Known decades before a SARM was a SARM.

>> So if they are being serious, should they drop this program, and deploy their resources elsewhere? <<

Why? My mom never got back on her feet, despite physical therapy, after five days of hospitalization. She died soon thereafter. I haven't seen mention of any sudden toxic reaction to 5211, perhaps there is room to explore additional indications.

>> They state their trial was not powered for significance on this endpoint. LMAO! <<

Walk tests have large standard deviations. And this trial mixed guys like me in with postmenopausal types with osteoporosis.

I notice that he/she/it chooses not to highlight triglycerides. Nor did h/s/i point to "Hormone levels and lipids returned to baseline after treatment discontinuation." Last, you get the feeling that h/s/i doesn't know that LGD-4033 **is* VK5211??



To: tuck who wrote (11713)10/2/2018 2:48:43 PM
From: Miljenko Zuanic  Read Replies (2) | Respond to of 12215
 
Hi Tuck,

Rick already responded in the way I would. IMO, 12w treatment duration is too short to produce "durable" effects, subject need to change physical activity to "keep" benefit on board.

However, my problem with 5211 is PARTNER! How many times you hear bios continuously talk about partner (laud)...and than ZERO materialize. If one have serious prospective partner...it does not talk about. Period! Partner does not like that and in "anger" my bail out!!!!

I hold all my shares, but wish I sold at least 3/4 @20-22. :-(

Cheers, Miljenko



To: tuck who wrote (11713)10/3/2018 11:16:19 AM
From: scaram(o)uche  Respond to of 12215
 
total cholesterol.....

scr.zacks.com

Largely "unch", so it didn't fit the glamour of the "reduced markers" sentence. Simple.



To: tuck who wrote (11713)10/4/2018 12:08:11 PM
From: Miljenko Zuanic  Respond to of 12215
 
RE: VRTX (2809)
ir.vikingtherapeutics.com

Is this: "too much noise from 45 subjects p2a trial?"

I still have better taste from P2a execution explanation!