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Biotech / Medical : Trillium Therapeutics -- Ignore unavailable to you. Want to Upgrade?


To: tuck who wrote (230)11/15/2018 12:40:25 PM
From: tuck1 Recommendation

Recommended By
ghmm

  Read Replies (1) | Respond to of 294
 
Further color on the CD47 antibody+rituxan combo. Note that the TRIL's advantage in RBC binding seems to have been nullified via priming and maintenance dosing with F59:

Anti-CD47 Antibody Plus Rituximab Demonstrates Efficacy in Half of Patients With Relapsed/Refractory NHL

Now, further depth, as it appears the germline source of the DLBCL really matters, and likely leads to good efficacy with a companion diagnostic to to find the right patients and then triple composing with CHOP (h/t to Dr. Paul DeSantis for the dig):

Expression Defines the Efficacy of Rituximab in Non-Germinal Center B-Cell (non-GCB) Diffuse Large B-Cell Lymphoma

Ways for competition to keep chipping away at TRIL keep showing up.

Cheers, Tuck