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Biotech / Medical : CLDX Celldex Therapeudics -- Ignore unavailable to you. Want to Upgrade?

To: scaram(o)uche who wrote (12)

1/15/2019 6:39:54 PM

From: scaram(o)uche

Respond to of 105

So, you drive proliferation of dendritic cells and then drive their differentiation, only to have Tregs come along and gobble up the presented antigen before it is presented to Tkillers??.....

Published: 14 January 2019

Regulatory T cells mediate specific suppression by depleting peptide–MHC class II from dendritic cells Billur Akkaya, Yoshihiro Oya, Munir Akkaya, Jafar Al Souz, Amanda H. Holstein, Olena Kamenyeva, Juraj Kabat, Ryutaro Matsumura, David W. Dorward, Deborah D. Glass & Ethan M. Shevach
Nature Immunology (2019)

Abstract
Regulatory T cells (Treg cells) can activate multiple suppressive mechanisms in vitro after activation via the T cell antigen receptor, resulting in antigen-independent suppression. However, it remains unclear whether similar pathways operate in vivo. Here we found that antigen-specific Treg cells activated by dendritic cells (DCs) pulsed with two antigens suppressed conventional naive T cells (Tnaive cells) specific for both cognate antigens and non-cognate antigens in vitro but suppressed only Tnaive cells specific for cognate antigen in vivo. Antigen-specific Treg cells formed strong interactions with DCs, resulting in selective inhibition of the binding of Tnaive cells to cognate antigen yet allowing bystander Tnaive cell access. Strong binding resulted in the removal of the complex of cognate peptide and major histocompatibility complex class II (pMHCII) from the DC surface, reducing the capacity of DCs to present antigen. The enhanced binding of Treg cells to DCs, coupled with their capacity to deplete pMHCII, represents a novel pathway for Treg cell–mediated suppression and may be a mechanism by which Treg cells maintain immune homeostasis.