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Biotech / Medical : Zonagen (zona) - good buy? -- Ignore unavailable to you. Want to Upgrade?

To: Anaxagoras who wrote (1841)	1/18/1998 12:12:00 AM
From: poodle	Respond to of 7041

Numbers: From J Urol 1988 Dec;140(6):1415-1416 1mg/ml phentolamine 1 ml injection intracavernous (pennis) Even (!) if you do not consider organ-specific efect of injection. 1mg of phentolamine 5 liters of blood Calculation of final concentration: Remember: 1mg=1000 mkg 1mkg=1000 ng 1000mkg/5000ml=0.2 mkg/ml=200ng/ml Final concentration: 200 ng/ml "With phentolamine alone 1 patiemt (7 per cent) reached full erection. " From asensio.com "Regular phentolamine reached a maximum blood concentration of 33 ng/ml in 30 minutes. Vasomax claims a level of 16.7 ng/ml in 30 minutes." Take the largest number (even): 33 ng/ml Compare with 200 ng/ml which was not effective. Remeber: site of injection was not considered yet. Disclaimer : All data are complete responsibility of authors. It would be nice to see any original data about phentolamine level. My calculations may contain mistakes. DO YOUR OWN. Correction: previously I posted 0.5 ml of phentolamine injection. 0.5 ml was really used in combination with papaverine. When phentolamine was tested alone, 1 ml was used. Good night.