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Biotech / Medical : Ligand (LGND) Breakout! -- Ignore unavailable to you. Want to Upgrade?


To: Andrew H who wrote (13537)1/20/1998 5:31:00 PM
From: Henry Niman  Respond to of 32384
 
CNBC just had Hemat Shah of HKS on and he reiterated what was said earlier. He thought that SBH and AHP had mediocre pipelines and had to spend $2-3 Billion on R&D each year. He also said that there would be significant cuts in overlap areas. He also mentioned smaller pharmas as merger candidates, but said management had to be interested (hostile takeovers would be hard). He listed SGP, WLA, Astra, and PNU.



To: Andrew H who wrote (13537)1/20/1998 6:19:00 PM
From: Henry Niman  Read Replies (3) | Respond to of 32384
 
Website just passed 3000 hits. Here's the numbers for the past 12 hours:

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To: Andrew H who wrote (13537)1/21/1998 12:25:00 AM
From: Henry Niman  Respond to of 32384
 
Here's what Dow Jones said about the combo:
Amer. Home, SmithKline Merger Said
"Logical Combination"

By Jennifer Fron Mauer and Louis Hau

NEW YORK (Dow Jones)--At first glance a merger between American
Home Products Corp. (AHP) and SmithKline Beecham Plc (SBH) appears
to be a "logical combination," according to industry watchers.

Strategically, recent mergers have caused both companies to slip in the
ranks of the world's biggest pharmaceutical companies.

Operationally, both companies have obvious strengths in several areas that
could benefit from merging. Analysts see significant cost savings by
combining marketing, research and development and administrative
operations.

Each has strong presence in the over-the-counter drugs and vaccine
manufacturing areas. American Home Products, which sells Robitussin
cough syrups and such painkillers as Advil and Anacin, has clearer strengths
in marketing in the U.S, while SmithKline Beecham, which sells Aquafresh
line of oral care products, is strong in Europe. Together they would be
strong across the board, according to Kenneth Nover, an analyst with A.G.
Edwards.

Combining their vaccine business would create a powerful force in this
lucrative, high growth industry, according to Steven Gerber, an analyst at
CIBC Oppenheimer. American Home Products, with its line of childhood
vaccines would provide the foundation, while SmithKline Beecham with its
adolescent and adult vaccines targeting such diseases as Hepatitis-B, and
plans for Lyme disease and herpes shots, would provide the sizzle, he said.

In addition, both companies have similar philosophies when it comes to
embracing newer technologies. Both have invested heavily in biotechnology.

American Home Products owns a majority interest in Immunex Corp.
(IMNX), and in December 1996, it paid $1.25 billion to buy the 40% of
Genetics Institute Inc. that it didn't already own. SmithKline Beecham, made
a $125 million investment in Human Genome Sciences Inc. (HGSI) in 1993.

And both companies come to the table with proven ability to complete
mergers and acquisitions that lead to cost savings, analysts said.

SmithKline Beckman Corp., Philadelphia, and Beecham Group PLC of
London merged in 1989 to form SmithKline Beecham PLC. American
Home acquired A.H. Robbins in 1989 and American Cyanamid Co. in
1993.

Analysts say the combined company could slash 30% or more of its
operating costs. If merged, the companies are likely to divest several
non-core units. American Home Products, which has been selling off its
medical products units, is likely to continue doing so. In addition, American
Home would likely consider selling its animal health and agricultural products
business, A.G. Edward's Nover said.

At the same time, SmithKline could sell its clinical lab testing business, he
said.

SmithKline has been making a big research push into the lucrative
osteoporosis market, where American Home has a major presence with its
estrogen-replacement treatment Premarin, according to Lisa Tuckerman, a
portfolio manager with Spears Benzak Salomon & Farrell.

SmithKline has research partnerships with a number of biotechnology
companies, such as NPS Pharmaceuticals Inc. (NPSP) and Human Genome
Sciences Inc. (HGSI), to develop osteoporosis therapies, among other
products.

American Home would give SmithKline "an instant sales force" familiar with
gynecologists and general-practice physicians who prescribe osteoporosis
drugs, Tuckerman said.

"SmithKline clearly wants to get into women's health," she said.

American Home has sharply raised its research & development spending
during the last few years and completed its ownership of biotech concern
Genetics Institute Inc. in December 1996.

Nonetheless, the company hasn't been known as a major innovator of new
products. Tuckerman described American Home as "a decent company but
clearly not a top-tier company" such as SmithKline, Merck & Co. (MRK),
Eli Lilly & Co. (LLY), Pfizer Inc. (PFE) and Glaxo Wellcome PLC (GLX).

Without the same research efforts as those leading players, American Home
could find it "difficult to be super-competitive over the long-term,"
Tuckerman said. A merger with SmithKline could help address this concern,
she said.

Steven Weisman, practice director for the U.S. pharmaceutical practice at
the Weinberg Group, a scientific consulting firm in Washington, D.C., said
that one area of controversy might be SmithKline and American Home
Products' investments in Human Genome Sciences and Immunex,
respectively. He suggested one or the other investment might have to be
spun off if SmithKline and American Home merge.

SmithKline was rumored to have offered to swap its vaccine business four
years ago to American Cyanamid Co. for that company's therapeutics
business, which included anti-infectives and oncology drugs, according to
Charlie Beever, a pharmaceutical consultant for Booz Allen & Hamilton Inc.
However, he noted, those negotiations were interrupted by American
Home's acquisition in 1994 of American Cyanamid.

"Probably some of the same rationale that drove those talks are driving these
talks," said Gerry Michel, also a pharmaceutical consultant for Booz Allen.

In the field of oncology drugs, American Home and SmithKline are both
"midsize, but you put them together and they get interesting," Beever said.

SmithKline's DPS pharmacy-benefit management subsidiary probably isn't a
major topic of interest in the merger talks, Beever said.

DPS, formerly known as Diversified Pharmaceutical Services, hasn't had the
positive impact on SmithKline's sales that had been expected, he said.

More successful pharmacy-benefit managers, such as Merck's Medco unit,
derive a large portion of their sales from mail-order pharmaceutical
purchases, Beever explained. He noted that DPS is "not very large in
mail-order."

A dark cloud of potential legal liability looms over any merger involving
American Home, analysts said. More than 200 lawsuits have been filed
against the company since it withdrew fenfluramine, a drug that when used
with another drug called phentermine, created the popular weight-loss drug
combination fen-phen. Phentermine is made by drug companies including
SmithKline, Medeva PLC and others.

American Home also withdrew Redux, another weight-loss drug, last year.
Redux had been linked to primary pulmonary hypertension, a rare,
sometimes fatal, lung condition.

Linda Miller, who manages the $120 million John Hancock Global Rx Fund,
says such a merger makes sense. Consolidation within the pharmaceutical
industry would create obvious economies of scale, she said.

"Both managements have a great deal of expertise, both have been at the
forefront of consolidation," she said.

Miller said that while there are always last-minute items that could break up
such a deal, it is likely the two will combine operations in some way.
Companies of this size and stature typically don't announce they're in talks
unless they are close to announcing something, she said.

"Today the market is saying it's gone through," she said, noting investors
bought up shares of both companies.

Shares of American Home Products were up 13 9/16, or 16.8%, at 94 1/4,
while SmithKline Beecham gained 2 9/16, or 4.5%, to 59 9/16.

-Jennifer Fron Mauer; 201-938-5287

-Louis Hau; 201-938-5240



To: Andrew H who wrote (13537)1/21/1998 12:31:00 AM
From: Henry Niman  Respond to of 32384
 
Here's more on mergers:

Amer Home, SmithKline Deal Would
Benefit Two Wall St. Firms

By Jeff Benjamin and Gaston F. Ceron

NEW YORK (Dow Jones)--Two Wall Street firms stand to reap a windfall
if American Home Products Corp. (AHP) merges with SmithKline Beecham
PLC (SBC).

American Home and SmithKline Beecham have confirmed they are
discussing a possible merger, but have not released any details and said they
will not make further comments unless an agreement is reached.

Sources familiar with the situation told Dow Jones that Morgan Stanley,
Dean Witter, Discover & Co. (MWD) is the financial adviser for
SmithKline, and Bear Stearns Cos. (BSC) is American Home's adviser.

Officials at Morgan Stanley and Bear Stearns did not immediately return
phone calls.

While much depends on the structure of the anticipated deal, such as
whether the transaction involves cash and/or stock, securities analysts
estimate that such a merger of equals could possibly generate as much as
$50 million in fees for financial advisers.

Analysts say there is no standard payment structure in a merger transaction.
But they note that a deal which involves companies with more than $100
billion in market capitalization would likely be kept below 50 basis points.

According to analysts, a merged SmithKline and American Home, with a
market capitalization of about $115 billion based on Friday's closing prices,
would be the second-largest drug company behind Merck & Co. (MRK),
with a market capitalization of $131.5 billion, according to First Call Corp.

The sources also said the New York law firm of Simpson Thacher &
Bartlett is working as the principle legal counsel for American Home, with
the U.K. law firm of Freshfield as a secondary counsel.

SmithKline's legal team is headed by Linklaters & Paines of the U.K., along
with the New York law firm of Sherman & Sterling.

According to statistics from Securities Data Co., the top five world-wide
merger and acquisition transactions of all time are:

- WorldCom Inc.'s (WCOM) $41.9 billion bid for MCI Communications
Corp. (MCIC), announced in October 1997.

- Mitsubishi Bank Ltd.'s 1996 acquisition of Bank of Tokyo Ltd. for $33.8
billion.

- Kohlberg Kravis Roberts & Co.'s 1989 acquisition of RJR Nabisco Inc.
for $30.6 billion.

- Sandoz AG's 1996 acquisition of Ciba-Geigy AG for $30.1 billion.

- Mitsui Bank Ltd.'s 1990 acquisition of Taiyo Kobe Bank Ltd. for $23
billion.

These are the top five domestic merger and acquisition transactions of all
time:

- WorldCom Inc.'s (WCOM) $41.9 billion bid for MCI Communications
Corp. (MCIC), which was announced on October 1997.

- Kohlberg Kravis Roberts & Co.'s 1989 acquisition of RJR Nabisco Inc.
for $30.6 billion.

- Bell Atlantic Corp.'s (BEL) 1997 acquisition of NYNEX Corp. for $21.3
billion

- Walt Disney Co.'s (DIS) 1996 acquisition of Capital Cities/ABC Inc. for
$18.8 billion.

- First Union Corp.'s (FTU) $17.1 billion bid for CoreStates Financial
Corp. (CFL), which was announced on November 1997.

The top five drug industry merger and acquisition transactions of all time are:

- Sandoz AG's 1996 acquisition of Ciba-Geigy AG for $30.1 billion.

- Glaxo Holdings PLC's 1995 acquisition of Wellcome PLC for $14.3
billion.

- Bristol-Myers Co.'s 1989 acquisition of Squibb Corp. for $12.1 billion.

- Roche Holding AG's $11 billion bid for Corange Ltd., announced in May
1997.

- American Home Products Corp.'s (AHP) 1994 acquisition of American
Cyanamid Co. for $9.6 billion.

-Jeff Benjamin; 201-938-2118

-Gaston F. Ceron; 201-938-5174



To: Andrew H who wrote (13537)1/21/1998 12:35:00 AM
From: Henry Niman  Respond to of 32384
 
OOther merger candidates:
SmithKline-Amer Home Not Seen Giving
Drug Cos Urge To Merge

By Jill Goldsmith

NEW YORK (Dow Jones)--A possible merger of SmithKline Beecham
PLC (SBH) and American Home Products Corp. (AHP) isn't necessarily a
harbinger of another consolidation wave in the pharmaceutical business
although a handful of companies still appear ripe to be bought out or to buy
someone else, analysts said.

Vaunting record earnings and stellar stock market valuations, most drug
companies don't have a pressing need to get any bigger, noted Cynthia
Beach of Gerard Klauer Mattison & Co. With stocks at record highs,
drug-company mergers would be quite expensive.

Also, there is much less of an imperative to consolidate than existed in the
late 1980s and early 1990s, when the shadow of health-care reform
prompted many companies to seek cost savings through consolidation, said
Michael Krensavage of Brown Brothers Harriman & Co.

"The market is reacting favorably but I don't see this as a big foreteller of
what's going to happen - because it doesn't make sense," Beach said.
"Earnings growth is the best it's ever been. PE (price-to-earnings multiples)
and valuations are at an all-time high. Bigger is not always better."

The stock market, hopeful for fresh deals, boosted the entire group of
pharmaceutical companies - several to new 52-week highs - on Tuesday.

Beach and others acknowledged, however, that the industry could well see
some merger-and-acquisition movement whether or not talks between
SmithKline and American Home Products do indeed end in a deal that
would form the world's second-largest drug concern.

One candidate that appears ripe for a takeover is Pharmacia & Upjohn Inc.
(PNU). Created by the combination of Upjohn Co. of the U.S. and
Sweden's Pharmacia AB in 1995, Pharmacia has been swept by
management turmoil for the past year. Former American Home Products
executive Fred Hassan was named Pharmacia's chief executive in July. "It's
been one of the poorest performers in the group and has had difficulty
making the merger work," noted Louis Webb of Fahnestock & Co.

It isn't clear who would be the likeliest buyer. Krensavage said he would like
to see the company split in two once again, with the European operations
going back to Europe and the American business sold to a U.S. concern.

Another thing that could push a company to consider a merger is the loss of
patent protection on individual drugs - a potentially dangerous situation for
drug companies and one that helped spur the corporate mergers that
became Bristol-Myers Squibb Co. (BMY), Hoffman-La Roche & Co. and
Glaxo Wellcome PLC. (GLX). Krensavage noted that Merck & Co.
(MRK) faces some significant patent expirations in 2000. That means, he
said, "they may be interested in making an acquisition" that could insulate it
from the competition from generic brands that follows patent expiration.

All the analysts noted that takeover rumors have been dogging smaller-cap
drug companies like Warner-Lambert Co. (WLA), Schering-Plough Corp.
(SGP) and Zeneca Group PLC (ZEN) for years. But they don't seem to
think deals are any more likely now than they have been in the past.

-Jill Goldsmith; 201-938-5234



To: Andrew H who wrote (13537)1/21/1998 1:11:00 AM
From: Henry Niman  Respond to of 32384
 
Here's what AP had to say:
Drug Stocks Rally on Takeover Talks
Drug Giants Discuss Merger

BUSINESS NEWS


QUOTES

Stocks
by name
by symbol
Mutual Funds
by name
by symbol




E-mail
ABCNEWS.com

Quote delayed at
least 20 minutes

By John Hendren
The Associated Press
N E W Y O R K, Jan. 20 - SmithKline Beecham
and rival drug maker American Home Products
said today they are considering the biggest
corporate merger ever. The news sent stocks of
other pharmaceutical companies higher as Wall
Street poised for another round of merger mania.
Investors speculated that if two of the world's biggest drug
makers combine, the deal would set off a repeat of the drug
industry's 1996 frenzy among drug makers.
"There will be another wave of consolidation," said
Hemant K. Shah, an independent drug industry analyst in
Warren, N.J. "If this goes through, some other companies will
have to think. How do you compete?"
In separate statements, American Home and SmithKline
Beecham said there are no guarantees the talks will lead to a
merger. The drug makers declined further comment until the
discussions are concluded.

Deal Eclipses MCI Takeover
It remains unclear how the deal would be structured, but
analysts say the combined company would likely be a merger
of equals based somewhere in the drug corridor that stretches
from New York to Philadelphia.
At today's stock price, American Home is worth about
$58 billion. If SmithKline, valued at more than $63 billion,
were to buy American Home, the deal would eclipse the
most expensive merger announced to date, the planned
buyout of MCI Communications by WorldCom for stock
valued at about $37 billion.
The combined company would have combined sales of
about $24 billion, giving it the most health-care revenues of
any company. Five other companies, including Nestle, have
more overall sales, but much of their revenue comes from
outside the health care business.
"On top of that they will become the leading consumer
brand company in over-the counter products," Goldman
Sachs analyst Prem Lachman said.

Opposites Attract
A merger would also unite two companies divided by history
and an ocean. Madison, N.J.-based American
Home-whose vast product line includes Robitussin cough
medicines, Advil pain relievers and the nation's
most-prescribed drug, the estrogen compound Premarin-is
82-years old.
Its drug-making division, Wyeth-Ayerst Laboratories,
goes back to 1860, when John Wyeth and his brother Frank
established a drugstore in the unit's current home of
Philadelphia.
London-based SmithKline-maker of the antidepressant
Paxil and over-the-counter products such as Aquafresh
toothpaste, Geritol vitamins, the Nicoderm anti-smoking
patch and Tum's antacids-was created in the 1989 merger
of SmithKline Beckman and Britain's Beecham Group.
Its roots go back to 1830, when John K. Smith opened
his first drug store in Philadelphia, where the company keeps
its U.S. headquarters.

News Boosts Drug Stocks
News of the talks drove up the price of American Home
Products' stock $9.81 to $90.50 on the New York Stock
Exchange by midafternoon, and SmithKline Beecham's
U.S.-listed shares rose $2.31 to $59 on the NYSE.
SmithKline's 4 percent increase followed a 7 percent rise
on the NYSE Friday.
Shares of the nation's largest drug companies bolted on
news of the talks, led by Warner-Lambert Co., up $7.56 to
$136 11/16 on the NYSE. Shares of Bristol-Myers
Squibb, Glaxo Wellcome, Eli Lilly & Co., Pfizer,
Pharmacia & Upjohn and Schering-Plough all saw
substantial gains.

Bigger Is Better
The potential deal highlights a fact of life in the drug industry:
size matters.
The combined company's mass would make it a
powerhouse in cardiovascular, central nervous system and
arthritis drugs, antibiotics and vaccines and give it competitive
advantage in several areas.
It could cut 20 to 25 percent of its operating expenses in
by eliminating duplication in research, manufacturing and
administration, Shah said.
Its combined $3 billion in annual research and
development funds, the key to future earnings growth, would
exceed the $1.7 billion spent by Whitehouse Station,
N.J.-based Merck & Co. and the nearly $2 billion spent by
New York-based Pfizer.
The new company's research spending would likely be $2
billion to $2.5 billion after it ends some duplicated projects,
analysts said.

Pharmacy Benefits Impacted
American Home would also gain one of the nation's largest
pharmacy benefit managers, SmithKline's Diversified
Pharmaceutical Services Inc. PBMs contract with health
maintenance organizations to buy prescription drugs at
discount prices.
PBMs can use their influence to help get their parent
company's drugs on the list of medicines HMOs approve for
their patients. Merck and Eli Lilly already own pharmacy
benefit businesses.
At 60, American Home's chief executive, John R.
Stafford, could be ready for a successor such as his friend,
SmithKline CEO Jan Leschly, 57.
American Home's stock has been pummeled since it
recalled two diet drugs, Redux and Pondimin, at the U.S.
Food and Drug Administration's request in July. A Mayo
Clinic study had linked the drugs with heart-valve damage.
The company also faces lawsuits from 50,000 women who
claimed the company failed to warn them adequately about
the side-effects of its Norplant surgically implanted
contraceptive.



To: Andrew H who wrote (13537)1/21/1998 2:47:00 PM
From: celeryroot.com  Read Replies (2) | Respond to of 32384
 
It is bad enough to have to worry about Asia, now we have to worry about a zipper