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Biotech / Medical : Zonagen (zona) - good buy? -- Ignore unavailable to you. Want to Upgrade?

To: poodle who wrote (1871)	1/20/1998 6:50:00 PM
From: Dr. Voodoo	Read Replies (1) \| Respond to of 7041

No blood level data in the abstract. I would believe Asensio's data regarding blood levels--JMO. Two things come into question though. 1.) Asensio quoted from a 1975 study of Phentolamine levels in blood. I do not believe that this study had anything to do with ED. It has just been used to show that the pills that are being produced are not any more fast acting than eating pure phentolamine. He says that Zonagen has claimed novelty in their patent application because they have developed a fast acting phentolamine tablet. A word of caution in interpreting Asensio's release: I have not seen from this any data that compares intitial dosage of phentolamine given to patients, the method used to measure phentolamine in the blood etc. This is the information that I would like to glean from the patent application. The war of words comming from both sides has failed to address these issues. 2.) As I said before, and I will expound more clearly, I do not doubt Zona's data regarding clinical trials. I looked, albeit not very hard, and could not find one study other than Zona's that shows oral phentolamine as a therapy for ED. Some very knowledgable people who post on the VVUS and other threads have stated that phentolamine oral therapy for ED is likely to not work. Some of these people have patents and patent applications in the ED field. The clinical data suggests that there could be more to ED than "local hydrolics". But again what can you make of clinical data where 30% of the patients respond to placebo. I have not taken a position in ZONA. I will likely wait quite a while to figure out which side of the whipsaw I want to be on. I am still digging through the literature. If anyone who reads this post and finds any misconception on my part please feel free to respond with literature references and patent applications ;-).