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To: skinowski who wrote (708043)3/23/2020 10:20:03 AM
From: carranza21 Recommendation

Recommended By
locogringo

  Read Replies (2) | Respond to of 793845
 
Remember our discussion about ACE-2?

Quoting from a 2005 peer reviewed article: virologyj.biomedcentral.com

In addition to the well-known functions of chloroquine such as elevations of endosomal pH, the drug appears to interfere with terminal glycosylation of the cellular receptor, angiotensin-converting enzyme 2.

Note/edit: Glycosylation refers to the attachment process, so in layman’s terms, quinine-derived stuff prevents attachment. I wish these guys would write in a way an interested amateur could comprehend.

Message 32612971

Obviously, SARS to which the article refers is not cv-19. But it is a corona virus. Quinine and it’s artificial analogues should have been a serious focus of research from the git-go. If I could find the article, virologists could too.



To: skinowski who wrote (708043)3/23/2020 10:34:11 AM
From: D. Long6 Recommendations

Recommended By
lightshipsailor
pak73
skinowski
Thehammer
Tobias Ekman

and 1 more member

  Read Replies (1) | Respond to of 793845
 
And importantly - it is legal for prescribers to use the drug off-label, but it is illegal for manufacturers to market and sell it for off-label use. That is a huge area of liability for Bayer, Teva, and others if they sell mass quantities knowingly for off-label use. The FDA needs to move to approve and sanction these drugs asap.