To: arun gera who wrote (155942 ) 4/4/2020 11:03:36 AM From: sense 2 RecommendationsRecommended By Pogeu Mahone THE ANT
Read Replies (1) | Respond to of 218882 I don't know why otherwise intelligent and sensible people like you get sucked into the political propaganda (in this case with underlying religious undertones). By "propaganda" you mean, this: President Clinton's Clean Water Initiative ? I "get sucked into the political propaganda" of believing that's what happened... because that's what happened. It appears Trump derangement syndrome is a powerful enough temporal functional narcotic that it now extends its deranging impacts all the way back to the Clinton era ? FWIW... I worked for the Clinton White House at the time... and the initiative was in part a response to my own inputs. Not sure how you get "religious undertones" out of a post on the science of drugs and biochemical functions of minerals... but apparently... religious bigots are easily incited by things imaginary that they find threatening. As a general rule, if you want to criticize people successfully... it would be useful to know what you're talking about before making the attempt ? Google it. Just not that had. And then you throw around buzz words - flocculation, clarifiers, precipitating, etc. Your lack of scientific depth in water processes is showing LOL!!! Yeah. I worked my way through college... including 2+ year of upper level organic chemistry... in part by working at a water treatment company... and later, provided the scientific and engineering validation for my own community's water system improvement plans... as we worked to implement our program to attain full compliance with the Clinton's changed standards ? And, it was that very same system that had made me aware enough of the nature of the problem... to highlight the nature of the problem to others ? The Clinton's improvement plans were, as is often true of government programs, overly "one size fits all"... initially based in assuming "water is water"... when water is inconveniently non-uniform. But the motivation in the implementation was driven primarily by terrorism concerns... having identified water sources as an obvious weak point, they proceeded to "fix it"... which was mostly a very good idea. The issues with water treatment chemistry... vs. upgraded physical infrastructure... not unlike others in which unintended consequences might prove problematic. None of that is a function of an upgraded physical infrastructure ? You also seem to suffer under the illusion that minerals in biochemistry are "alchemy"... ? That's deranged... probably an artifact of too much fluoride in your toothpaste... but, OK. The issue in Alzheimer's... at least as far as memantine's functions... are all about management of mineral flows in nerve cells. The NMDA (N-Methyl-D-Aspartate)-receptor subtype of glutamate receptors are gates of channels for calcium flows, which are normally carefully limited in how much calcium they allow past, gated in part by the presence of magnesium blocking the channels... but Alzheimer's, for some reason, excites the NMDA gates... loosing the magnesium... allowing too much calcium to flow in. Too much calcium is highly toxic... and it quickly kills cells. Programmed cell death uses the same method to get rid of cells... flooding them with calcium to kill them. In Alzheimer's brain cells that shouldn't die are killed by excess calcium. Memantine modifies the gates to "calm them down"... so the magnesium that's there blocks calcium better again. But, you can accomplish the same thing just by ensuring there's more magnesium present to be there and compete for access to the site to block it... ? So in proving the drug works to the FDA... they'll compare it with X amount of magnesium for a % comparability in quantifying impact... but when they test the drug for proofs of effectiveness they compare it instead to placebo ? Gee I wonder why. See for instance: Memantine ncbi.nlm.nih.gov The NMDA receptor is a voltage-gated cation channel that in the physiologic unstimulated state is blocked by magnesium ions. Stimulated magnesium is displaced allowing calcium influx and activation. In Alzheimer disease, there is pathologic overstimulation of the receptor causing it to be in a chronically active state. Memantine helps to counteract the excessive stimulation. [1] Memantine helps some people... at early to mid stages of disease progression. Others not at all. It's a very limited improvement enabled, too... but it clearly is meaningful for those it helps. Oddly, though, no one seem interested in studying other things with the same or similar function... like altering how much magnesium Alzheimer's patients should have in their diet ? Or, limiting calcium ? Or, other drugs known the same function... like... I stand corrected... someone HAS done a study on dextromethorphan. .. basic cough syrup ingredient... which also works better than memantine... and for more people... with broader impacts in its effects... but including modification of glutamate receptors.