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Strategies & Market Trends : 2026 TeoTwawKi ... 2032 Darkest Interregnum -- Ignore unavailable to you. Want to Upgrade?

To: stsimon who wrote (156234)	4/9/2020 8:50:27 AM
From: sense	Respond to of 218144

Too early to say what's behind it... Given the "unusual" aspects of this virus, though, I don't think you can assume that it's systemic functions are necessarily the same as its site specific functions... It might well be holing up and hiding out in some particular organ as a reservoir... Are the "re-eruptions" all males ? Lots of questions to ask... known sex differences suggest that as a place to start. My guess is... the traditional vector that medicine takes in solving a puzzle like this won't be helpful enough. Instead, we're going to have to see a line by line decoding of the genome lined up against the structures of the proteins on the surface... a re-interpretation of the viral proteins and their functions... and from that... and other information on similarities found in the sequences and functions of other pathogens... try to determine specific site affinities other than the ACE2... which accounts for only one of the four unique "inserts" known to be present on the "evolved" virus relative to others similar. Doesn't even need to be accelerated reproduction in the host site as occurs in ACE2... just a protected corner from which it can run at a low rate and enable an island as a survival colony... a "sticky" site... Sure would speed things up, now... if someone had taken (and published) solid notes describing origins/functions of the known protein sequences in relation to others known... Lyme disease... and AIDS virus... two other things known to have proteins that give them that sort of an ability to hide and survive unseen in hidden corners that are hard to get to in order to treat them. Lyme disease is another spirochete driven problem, like malaria... so the success of the malaria drugs might be relevant to spirochete type proteins more broadly... a survey effort perhaps not wasteful. The site specific protein linked issues might well be tied to the same/similar concern as the number of people who are found actively shedding virus without ever having become ill themselves... and the reason some get sicker than others ? Why are the age related and sex related issues... so obvious ? What is it about older vs. younger age, and the sex difference... that makes the virus more potent, or less so ? Each of those puzzles... will relate to a particular protein sequence and its interactions with some element of the genome of people having those different responses to the virus... those not becoming ill... or those potentially acting as a host or reservoir that makes them able to reinfect themselves... and others. Genetic similarities found between people in those different categories might provide clear clues... Half that puzzle is solved... if you can say why some people get sicker and others not at all... Solving one half... should help solve the other half...