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Politics : Formerly About Advanced Micro Devices -- Ignore unavailable to you. Want to Upgrade?

To: Brumar89 who wrote (1221730)

4/17/2020 4:36:02 PM

From: Brumar89

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rdkflorida2

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Hydroxychloroquine Trial for Treating COVID-19 Disappoints"The best available evidence does not support the use of hydroxychloroquine in COVID-19." RONALD BAILEY | 4.16.2020 3:10 PM

(Amlan Mathur | Dreamstime.com)

A just-reported Chinese study compares the clinical outcomes of COVID-19 patients treated with hydroxychloroquine with those of patients receiving standard of care. The results, alas, are disappointing.

I summarized that study in my roundup yesterday of COVID-19 therapeutic research, pointing out that this randomized controlled trial of 150 patients "found no difference in the rate of viral load reduction or symptom alleviation between the group treated with hydroxychloroquine and the one that had not been." Now the University of Vermont pulmonologist Josh Farkas has published his own analysis of the results, delving more deeply into the data.

The patients in both arms of the study were well-matched demographically and clinically, Farkas notes. Most suffered relatively mild cases of the disease, and treatment was initiated fairly late—about 16 to 17 days after disease onset. Twenty-eight days into the trial, the researchers found essentially no difference between the two cohorts with respect to the percent of patients in which the virus was undetectable.

Tang et al.

Farkas adds:

This endpoint most directly addresses the question: does hydroxychloroquine exert anti-viral activity in vivo? The answer seems to be: nope. Even if the drug were administered too late to affect the clinical course of the infection, if it exerted any anti-viral activity then we might expect to see that effect here. If anything, there might be a trend towards delayed viral clearance in patients treated with hydroxychloroquine.

The study also found that fever and respiratory symptoms did not abate any faster in patients who had been treated with hydroxychloroquine.

Farkas acknowledges the study's limits, including its small size and that the researchers were not blinded—that is, they knew which patients were being given the treatment. "Nonetheless," he says, "this study currently represents the highest available quality of evidence regarding hydroxychloroquine."

"For now, the best available evidence does not support the use of hydroxychloroquine in COVID-19," Farkas concludes. "It seems prudent to restrict the use of hydroxychloroquine to randomized controlled studies for the time being." He does acknowledge that future studies in which COVID-19 patients are treated earlier in the course of their infections may yet find that hydroxychloroquine offers some therapeutic benefits. Fingers crossed.

reason.com

To: Brumar89 who wrote (1221730)

4/17/2020 5:04:18 PM

From: Maple MAGA

3 Recommendations

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FJB
Mick Mørmøny
Winfastorlose

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Matthew 6:1-6, Jesus says:

“Be careful not to practice your righteousness in front of others to be seen by them. If you do, you will have no reward from your Father in heaven.

2 “So when you give to the needy, do not announce it with trumpets, as the hypocrites do in the synagogues and on the streets, to be honored by others. Truly I tell you, they have received their reward in full. 3 But when you give to the needy, do not let your left hand know what your right hand is doing, 4 so that your giving may be in secret. Then your Father, who sees what is done in secret, will reward you.

5 “And when you pray, do not be like the hypocrites, for they love to pray standing in the synagogues and on the street corners to be seen by others. Truly I tell you, they have received their reward in full. 6 But when you pray, go into your room, close the door and pray to your Father, who is unseen. Then your Father, who sees what is done in secret, will reward you.