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Biotech / Medical : Zonagen (zona) - good buy? -- Ignore unavailable to you. Want to Upgrade?

To: Cacaito who wrote (2089)	1/27/1998 10:19:00 PM
From: Dr. Voodoo	Respond to of 7041

Thanks for your post. Now your going to make me show off my ignorance by explaining my guess. Here's what I am thinking. DISSOLVED Phentolamine absorption in the gut is controlled by one thing and one thing only--phentolamine. Whether or not you put it in a rapidly dissolving pill or in a slow dissolving pill may or may not make much difference as long as you do not give a toxic dose. Is 26.33 minutes versus 1 minute dissolution regarding absorption into the bloodstream significant? Maybe, but only if the drug is metabolized before in enters the bloodstream or the rate of dissolution limits the drug concentration in blood. Here's the guess--I do not have data on this, my guess is that roughly the same amount get's absorbed(based on physiological data), it just takes longer, thus shifting the time points but not the blood concentration. Just a guess, let me know where the flaw is.