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Biotech / Medical : CLDX Celldex Therapeudics -- Ignore unavailable to you. Want to Upgrade?

To: Miljenko Zuanic who wrote (73)	6/7/2020 3:54:56 PM
From: wood_ny	Read Replies (2) \| Respond to of 105

DCM is another good target for 0159 Diffuse cutaneous mastocytosis (DCM) is seen in children and is the most severe form of cutaneous mastocytosis. The skin is diffusely thickened and discolored, generally without individual distinct lesions. Additional symptoms associated with DCM include itching, blistering, decreased blood pressure (hypotension), diarrhea, gastrointestinal bleeding, reddening of the skin (flushing), and anaphylactic shock. The most common c-kit mutation in mastocytosis is D816V and is believed to cause the abnormal proliferation and accumulation of mast cells in tissues. Approximately >90% of adults and 40% of children also express this mutation whereas another 40% of children have mutations involving other areas of KIT. rarediseases.org.