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Biotech / Medical : Neurobiological Tech (NTII) -- Ignore unavailable to you. Want to Upgrade?


To: Dr. John M. de Castro who wrote (235)1/28/1998 9:02:00 PM
From: John Wright  Read Replies (1) | Respond to of 1494
 
John, thanks for the good news update. Also some interesting and positive comments from Paul Freiman i.e. "....and I expect it to generate considerable interest in the pharmaceutical community. We are now in negotiations with potential partners regarding collaborations...."

Thoughts, opinions, anyone?

John



To: Dr. John M. de Castro who wrote (235)1/28/1998 9:38:00 PM
From: Cacaito  Read Replies (1) | Respond to of 1494
 
The P value is probably wrong (less than 0.10) should be 0.01 to be
statistically significant.

Good news.

The lack of action in post herpetic (varicella/zoster) neuralgia is interesting since the phisiology is quite different to the diabetic cases.

Probably dynorphin A will be more effective in pain reduction.

Could Memantine protect the diabetic patients before all the damage or halt the ongoing process? They are trying to use it as a central neuroprotective.

Could the pain relief be an early evidence of this protective effect?

Just for the fun of thinking and guessing

Lets see how the market like it.



To: Dr. John M. de Castro who wrote (235)8/16/1999 2:09:00 PM
From: BRAVEHEART  Read Replies (1) | Respond to of 1494
 
Another Article...John this one is directed at you & Terry...

See:

Message 3286833

Given the prior P-2 trial success of 30% reduction in pain for Nocturnal Diabetic Neuropathies in a mixed trial. What percentage in the current more specific trial would suggest statistical significance and result in advancing to Phase Three testing. Would a similar result give rise to a Phase Three trial?

Thanks
Jeffrey