I'd be dubious of taking a vaccine not tested properly, the first Polio vaccine was a disaster
The tainted polio vaccine that sickened and fatally paralyzed children in 1955
It was ‘one of the worst biological disasters in American history,’ one scholar wrote
On Aug. 30, 1954, Bernice E. Eddy, a veteran scientist at the National Institutes of Health in Bethesda, Md., was checking a batch of a new polio vaccine for safety.
Created by Jonas Salk, the vaccine was hailed as the miracle drug that would conquer the dreaded illness that killed and paralyzed children. Eddy’s job was to examine samples submitted by the companies planning to make it.
As she checked a sample from Cutter Laboratories in Berkeley, Calif., she noticed that the vaccine designed to protect against the disease had instead given polio to a test monkey. Rather than containing killed virus to create immunity, the sample from Cutter contained live, infectious virus.
Something was wrong. “There’s going to be a disaster,” she told a friend.
As scientists and politicians desperately search for medicines to slow the deadly coronavirus, and as President Trump touts a malaria drug as a remedy, a look back to the 1955 polio vaccine tragedy shows how hazardous such a search can be, especially under intense public pressure.
Despite Eddy’s warnings, an estimated 120,000 children that year were injected with the Cutter vaccine, according to Paul A. Offit, director of the Vaccine Education Center at Children’s Hospital of Philadelphia.
Roughly 40,000 got “abortive” polio, with fever, sore throat, headache, vomiting and muscle pain. Fifty-one were paralyzed, and five died, Offit wrote in his 2005 book, “The Cutter Incident: How America’s First Polio Vaccine Led to the Growing Vaccine Crisis.”
It was “one of the worst biological disasters in American history: a man-made polio epidemic,” Offit wrote.
In those days, polio, or infantile paralysis, was a terror.
“A national poll … found that polio was second only to the atomic bomb as the thing that Americans feared most,” Offit wrote.
“People weren’t sure how you got it,” he said in an interview last week. “Therefore, they were scared of everything. They didn’t want to buy a piece of fruit at the grocery store. It’s the same now. … Everybody’s walking around with gloves on, with masks on, scared to shake anybody’s hand.”
“I remember my mother … wouldn’t let us go to a public swimming pool,” said Offit, 69. We “all had to go into one of those little plastic pools in the back so that we wouldn’t be in a public place.”
The worst polio outbreak in U.S. history struck in 1952, the year after Offit was born. It infected 57,000 people, paralyzed 21,000 and killed 3,145. The next year there were 35,000 infections, and 38,000 the year after that.
Many survivors had to wear painful metal braces on their paralyzed legs or had to be placed in so-called iron lungs, which helped them breathe. There was no vaccine and few treatments. (One bogus approach was to spray acid into the noses of children to block the virus. All it did was ruin the sense of smell.)
Often polio victims were children, but the most famous affected American was President Franklin D. Roosevelt, who got polio and was paralyzed from the waist down in 1921 when he was 39.
In 1951, Jonas Salk of the University of Pittsburgh’s medical school received a grant from the National Foundation for Infantile Paralysis to find a vaccine. During intense months of research, he took live polio virus and killed it with formaldehyde until it was not infectious but still provided virus-fighting antibodies.
When tests showed that the vaccine was safe, Salk told his wife, “I’ve got it,” Offit wrote.
Word of his success soon leaked out. Public pressure grew for the vaccine and for a large-scale trial.
In 1953, Salk tested it on himself, his wife and three children.
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On April 26, 1954, Randy Kerr, a 6-year-old second-grader from Falls Church, Va., stood in the cafeteria of the Franklin Sherman Elementary School in McLean and became the first to be vaccinated in a massive field study.
Salk’s vaccine was given to 420,000 children. A placebo was given to 200,000. And 1.2 million were given nothing.
The study found that children who did not get the vaccine were three times more likely to be paralyzed with polio than those who received the vaccine.
A year later, on April 12, 1955, when officials announced the results at a news conference at the University of Michigan, there was jubilation. Reporters hollered: “It works! It works!” Offit wrote.
The news made front-page headlines across the country. “People wept,” Offit said. “There were parades in Jonas Salk’s honor. … That’s what contributed to the tragedy of Cutter more than anything else … the irony.” |
