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Biotech / Medical : Zonagen (zona) - good buy? -- Ignore unavailable to you. Want to Upgrade?

To: Tokyo VD who wrote (2161)	1/30/1998 12:02:00 PM
From: Cacaito	Read Replies (2) \| Respond to of 7041

Voodoo, As per Zonagen's Joe P. CC: 1. IV phantolamine does not work. This was stressed to the point of saying something like "Dr Goldstein was worry at the beggining but then noticed the beauty of it, quick oral works, bypassed the liver (conjugation) and gets enough drug to the penis" not exact words. 2. There is only one phantolamine supplier in the world and is under contract with Zonagen. Could this supplier turn around and market by themselves? 3. Zonagen's supplier is the cheapest (I do not know how he compared this to, since there are not other suppliers.) But Joe wanted to stressed that even if somebody else comes after zonagen will still be the cheapest. NOT from CC: Then only Gwinup and Imhof (the prior art people) could challenge the existing patent? are they alive? Could Ciba-Geigy (now Novartis) claim rights they discovered the vasodilation effect? Zorgniotti argue with himself if the drug works due to the receptors in the brain, he discarded that idea, but no proof about it, since he only patented the "direct" penis effect, could somebody else claim the central (brain) receptor as the real mode of action and a new patent? It is not such a weird idea because it seems (if it does) to work only in mild ED or psychogenic ones. Blood levels is only a measure of the "fast" action pill, not of effectiveness. Gwinup got his numbers with the old pill (very few patients). Patent again, Zonagen's patent (the Zorgniotti one) listed at least Gwinup in the references. Somebody could check if they listed Imhof. Blood levels, the quicker levels, especially if repeated could lead to severe gastric bleeding. This is one of the less common, but most dreaded side effects of phentolamine. If patients has gastroduodenal ulcers it is contraindicated. I wish I were sure it does not work (or does) but I am left only to observe. The stock is still undergoing heavy distribution (bop tc 2000, and IBD change from A (best) to D (almost worst). Is there any evidence that the $10 millions from Schering are already in Zonagen hands. The PR release talk about undisclosed financial arragements. Is it possible to have a fineprint line and Schering get away with their money up to a certain date or "milestones"?