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Biotech / Medical : North American Vaccine -- Ignore unavailable to you. Want to Upgrade?

To: aknahow who wrote (260)	1/30/1998 2:15:00 PM
From: Rick Strange	Read Replies (1) \| Respond to of 507

The Dutch vaccine that failed gave immunity chiefly to strains of B. pertussis that carry normal pertactin. This vaccine did not have: pertussis toxoid (PI); filamentous hemagglutinin (FHA) or fimbriae (FIM). In the new strain, a point mutation in its genome has changed one of the amino acids in pertactin, a protein the bacterium carries on its surface. This disguise seems to fool an immune system primed to recognise normal strains of B. pertussis. If a child was vaccinated with a vaccince containing any of the other components listed above, that child would be immunised against this mutant strain. The vaccines used in Britain, France and Finland contain other components in addition to pertactin and that's why they work. The Dutch epidemic was caused because they relied upon the antibody responce to a single component and B. pertussis pulled a "hail Mary" leaving the Dutch in deep Polder.

To: aknahow who wrote (260)	1/30/1998 3:56:00 PM
From: Don W Stone	Read Replies (3) \| Respond to of 507

George: You'll right. It was the other nice guy, David B. We'll have to get him in the loop. Now to help you better understand what is not being said here I'll try to clarify one thing. 1) I certainly am not saying or even implying that the use of a multicomponent DTaP vaccine will cause an epidemic. That is senseless. There isn't a single vaccine out there that will cause an epidemic that i am aware of.. well Saddam mite have one,:-} George; go back to trying to sort out truth from fiction in that "SPECIAL REPORT" that came over your fax this morning.i.e. Stop the bleeding. Good Luck. :-}