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To: Copeland who wrote (735613)12/22/2020 9:37:57 PM
From: frankw1900  Respond to of 793883
 
I think this is outdated conclusion:

They passed out ivermectin like candy In Brazil and South America and didn't see much of an effect. It kills the virus in vitro but need much higher levels in the bloodstream to kill it reliably in vivo.
Up to date presentation by Pierre Kory which includes some statistical treatment of SA data:

Review of the Emerging Evidence For Use of Ivermectin in the Prophylaxis and Treatment of COVID



Research paper above presentation is derived from:


Review of the Emerging Evidence Demonstrating the Efficacy of Ivermectin in the Prophylaxis and Treatment of COVID-19






Authors
  • Pierre Kory
  • G. Meduri
  • Jose Iglesias, DOJoseph Varon, MDKeith Berkowitz, MDHoward Kornfeld, MD
  • Eivind Vinjevoll
  • Mitchell Scott
  • Fred Wagshul, MDPaul E. Marik, MD


    osf.io

    This will download paper in PDF form:

    osf.io

    ABSTRACT
    Abstract In March 2020, an expert panel called the Front Line COVID-19 Critical Care Alliance (FLCCC) was created and led by Professor Paul E. Marik, with the goal of continuously reviewing the rapidly emerging basic science, translational, and clinical data in order to gain insight into and to develop a treatment protocol for COVID-19. At the same time, many centers and groups employed a multitude of novel therapeutic agents empirically, and within clinical trials, often during inappropriate time points during this now well-described multi-phase disease. Either as a result of these frequent trial design failures, or due to the lack of their insufficient anti-viral or anti-inflammatory properties, nearly all trialed agents have proven ineffective in treating COVID-19 as of November 11, 2020. Based on a recent series of negative published therapeutic study results, in particular the SOLIDARITY trial, they now virtually eliminate any treatment role for remdesivir, hydroxychloroquine, lopinavir/ritonavir, interferon, convalescent plasma, tocilizumab, and monoclonal antibody therapy. Despite this growing list of failed therapeutics in COVID-19, the FLCCC recently discovered that ivermectin, an anti-parasitic medicine, has highly potent real-world, anti-viral, and anti-inflammatory properties against SARS-CoV-2 and COVID-19. This conclusion is based on the increasing numbers of study results reporting effectiveness, not only within vitro and animal models, but also in numerous randomized and observational controlled clinical trials. Repeated, large magnitude improvements in clinical outcomes have now been recorded when ivermectin is used not only as a prophylactic agent but also in mild, moderate, and even severe disease states. The review that follows of the existing evidence for ivermectin relies on “emerging” data in that, although compelling, only a minority of studies have been published in peer-reviewed publications with the majority of results compiled from manuscripts uploaded to medicine pre-print servers or posted on clinicaltrials.gov



    To: Copeland who wrote (735613)12/22/2020 10:30:09 PM
    From: Maple MAGA   Read Replies (1) | Respond to of 793883
     
    Apparently the manufacturer of this Ivermectin horse product is aware it may be used for humans.

    "Apple flavor that horses love! Removes worms and bots with a single dose. Safe to use on all horses, including broodmares, breeding stallions, and young foals. Paste-gel that is easy to administer. Allows horses to reach their full potential by providing effective, safe parasite protection. Convenient, easy-to-use syringe allows for fast, fool-proof application. INGREDIENTS: Ivermectin..........1.87% DIRECTIONS: One syringe contains sufficient paste to treat one 1250 lb horse at the recommended dose rate of 91 mcg ivermectin per lb (200 mcg/kg) body weight. Each weight marking on the syringe plunger delivers enough paste to treat 250 lb body weight. Please refer to label for complete use directions. WARNINGS: Keep out of reach of children! NOT SAFE OR APPROVED FOR HUMAN USE, WHICH COULD CAUSE SEVERE PERSONAL INJURY OR DEATH. COVID-19 ALERT CONCERNING DURVET IVERMECTIN PRODUCTS: WARNING! A number of Durvet products including Duramectin Equine Dewormer, Ivermectin Equine Dewormer, Ivermectin Sheep Drench, Ivermectin Pour On, Ivermectin Injection and Ivermectin Plus Injection contain the anti-parasite active ingredient Ivermectin. Despite media reports that Ivermectin could potentially be used to treat people with COVID-19, these products are not safe or approved for human use, which could cause severe personal injury or death."