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Biotech / Medical : Ligand (LGND) Breakout! -- Ignore unavailable to you. Want to Upgrade?


To: CYBERKEN who wrote (14028)2/1/1998 11:28:00 AM
From: Henry Niman  Respond to of 32384
 
Here's more from the Sunday's Time:

February 1 1998
BUSINESS NEWS

City to cheer
œ100bn drug deal

DRUG COMPANY shares are expected to soar when the
market opens tomorrow following the shock
announcement over the weekend of plans for a merger
between Glaxo Wellcome and SmithKline Beecham
(SKB) to create a company worth œ100 billion.

Analysts reacted enthusiastically to the deal, saying it
would create a formidable British force in one of the
world's largest industries.

"The stock market will welcome this deal," said Robin
Gilbert of Panmure Gordon.

The market reaction had been muted when 10 days ago
SmithKline announced it was in merger talks with
American Home Products, another drugs giant.

"That was a company that just grew by acquisition and had
a different culture from SmithKline," said Gilbert. "The
stock market will view this merger much more positively."

Few details of the merger have yet been worked out, but
already the market is calculating some of the potential
consequences. Some market watchers believe the
companies may pay out a special dividend to sweeten the
deal for shareholders.

This weekend both companies stressed that the main driver
of the deal was the hunt for critical mass in research and
development (R&D). Together, the merged business will
be spending œ2 billion a year on R&D, the biggest
expenditure of any company in the world.

It is understood Sir Richard Sykes, chairman of Glaxo
Wellcome, was particularly concerned about the plans by
SmithKline to abandon Britain and relocate to America.
He was keen to put forward an alternative plan that would
keep the company British.

The two companies have talked from time to time over the
past few years, and 18 months ago they agreed a
collaboration on antibiotics. Followers of corporate history
will also note the irony that in 1971 Beecham launched a
hostile bid for Glaxo that was blocked on competition
grounds. This deal is unlikely to fall on those grounds, but
competition regulators may insist that some drugs made by
the combined group are sold. The main areas of overlap
are anti-herpes drugs - Glaxo's Vatrex against SKB's
Fanvir - and anti-nausea drugs - Glaxo's Zofran against
SKB's Kytrel. When Glaxo took control of Wellcome, it
was forced to abandon several products.

Although the merged company will be by far the biggest
drugs player by any measure, it will still control only a small
percentage of the industry. The combined sales of the two
businesses will be less than 8% of the world market, but
that will be double its nearest rival, the Swiss giant
Novartis.

Job losses will be an inevitable consequence of the merger.
After the Glaxo Wellcome deal 8,000 jobs were lost from
the combined group, and up to 15,000 jobs could be lost
in the latest deal. Between them Glaxo and SmithKline
employ more 100,000 worldwide. "The combined
company can eliminate 25% of duplicate costs," said
Hemant Shah, an analyst with the American firm HKS.

The deal will give investors in Glaxo, advised by Lazards,
59.5% of the merged business. SmithKline's investors will
take 40.5%. Reflecting this balance, Sykes will be
executive chairman, and Jan Leschly, SmithKline's chief
executive, will be chief executive and chairman of the
executive management committee. Two other directors will
come from Glaxo, one from SmithKline.

Advisers believe the rivalry between Sykes and Leschly
has been put to one side. "You would be amazed at how
good the chemistry is between them," said one.

Although the key issues have been agreed, it will still be
several weeks before the deal is finally wrapped up. Even
the name has yet to be chosen.



To: CYBERKEN who wrote (14028)2/1/1998 11:31:00 AM
From: Henry Niman  Respond to of 32384
 
Here's more Reuter's:
Saturday January 31, 7:33 pm Eastern Time

SmithKline/Glaxo merger seen likely to spur peers

By Ransdell Pierson

NEW YORK, Jan 31 (Reuters) - A record-setting merger of British drug giants SmithKline
Beecham Plc (quote from Yahoo! UK & Ireland: SB.L) and Glaxo Wellcome Plc (quote from Yahoo! UK
& Ireland: GLXO.L), if consummated, is seen by Wall Street analysts as likely to incite a mating
dance among other major pharmaceutical companies.

SmithKline jilted New Jersey company American Home Products Co (AHP - news) Friday by
ending their two-month-old merger talks and announcing it was considering tying the knot instead
with London neighbor Glaxo after barely a week of courtship.

The $165 billion union -- SmithKline's market capitalization of $69 billion added to Glaxo's $96
billion -- would eclipse the record $37 billion merger sealed in November between WorldCom Inc
(WCOM - news) and MCI Communications Corp (MCIC - news).

''A merger of SmithKline and Glaxo would create a company with dramatic critical mass, which will
put pressure on all other top pharmaceutical companies to consider merging as well to increase their
market share,'' said Sven Borho, a drug analyst for OrbiMed Advisors in New York.

He said bigger was better, particularly in research and development, adding SmithKline and Glaxo
together would have a R&D budget of $3 billion -- 50 percent higher than any competitor.

''It would allow them to go after every single area of technology and every single therapeutic area,
whereas a lot of medium size companies can't afford all the cutting-edge technologies like genomics
and gene sequencing.''

Similarly, Borho said a combination of the SmithKline and Glaxo sales forces would create a
marketing juggernaut capable of launching drugs more quickly and into wider markets.

John Borzilleri, a drug analyst for State Street Research of Boston, said a matchup between
SmithKline and Glaxo would indeed have an aphrodisiac effect on other companies.

''It would put pressure on some to follow suit,'' he said, especially those unlikely to match 15-20
percent annual earnings growth seen in coming years for U.S. industry leaders such as Pfizer Inc
(PFE - news) and Warner-Lambert Co (WLA - news).

He and other analysts said outright purchases of larger drug companies would be almost impossible
because of their high valuations, leaving mergers as the alternative.

Borzilleri said a likely merger candidate was Merck & Co (MRK - news), the largest U.S. company
with a capitalization of $141 billion, which has enjoyed high-teen earnings growth in the past year
but faces an earnings slowdown because of patent expirations on five of its key drugs by the year
2001.

Likewise, he said American Home Products faces earnings pressure from a paucity of blockbuster
drugs, a lackluster pipeline of future drugs and possible multibillion-dollar liability for two obesity
drugs recalled last year because of heart-valve damage seen in some patients.

He said Bristol-Myers Squibb Co (BMY - news), with a $99 billion valuation, has had only average
earnings growth of about 13-14 percent and might ponder a merger as long as the New Jersey
health care giant held the dominant role.

But Neil Sweig, an analyst for Southeast Research Partners, said he did not believe a
SmithKline/Glaxo merger would spur widespread consolidation in the United States, adding that
most U.S. companies had nothing to gain from hooking up with others.

''Things couldn't be going better for them. They're reporting record profits, so why should they risk
upsetting their excellent business conditions today for the possibility of no gains or small gains
tomorrow,'' Sweig said.

Sweig said Merck, Bristol Myers, Pfizer, Warner-Lambert, Schering-Plough Corp (SGP - news)
and Eli Lilly and Co (LLY - news) all said in 1997 they had no interest in making major acquisitions,
adding he presumed they were also disinterested in mergers.

Borho disagreed, saying recent company statements amount to ancient history in view of Friday's
startling announcement by SmithKline and Glaxo.

''It's a whole changed landscape now and now everyone is going to feel more pressure to adapt,''
Borho said.

Sweig said American Home Products had special difficulties which behooved it to find a partner,
perhaps with a company in another industry such as consumer products or chemicals.

He added Pharmacia & Upjohn (PHU.ST) (PNU - news) might also need to team up with another
company because of its poor performance and sliding profits since being created by the merger of
Sweden's Pharmacia and U.S. company Upjohn in late 1995.

P&U is now based in Stockholm but will shift its headquarters to New Jersey in 1998.



To: CYBERKEN who wrote (14028)2/1/1998 12:01:00 PM
From: Henry Niman  Respond to of 32384
 
Here's more from London:

Huge job losses in drugs merger
By Neil Bennett

See graphic: Glaxo SmithKline- the new colossus

UP to 10,000 jobs will be lost in the œ100bn merger of Glaxo Wellcome
and SmithKline Beecham, as analysts predicted that the new group would
plan to cut costs by more than œ1bn a year.

The enlarged group is expected to shed at least a tenth of its workforce by
merging its research and development and sales and marketing operations
in Europe and America. About 2,000 of the jobs will be lost in Britain, out
of a 21,000 workforce. The cuts are forecast to boost group profits to
more than œ5bn by 2000.

Glaxo and SB announced plans late on Friday to merge and create the
world's largest pharmaceutical group, with sales of more than œ16bn a
year. SB also announced it was abandoning its earlier plans for a merger
with American Home Products, the US drugs group.

The new group, which is expected to be named Glaxo SmithKline, will
have its head office in London and will keep Glaxo's research centre in
Stevenage, Hertfordshire, and SB's in Harlow, Essex. But SB's head
offices and many of its other operations in Brentford, West London are
expected to be closed.

Yesterday it emerged that the two companies first held protracted merger
talks a year ago, but these broke down after the two sides failed to agree a
price and also could not decide on a role for Sean Lance, Glaxo's then
chief executive. It was only then that SB decided to look at US companies
for potential merger partners.

Last year's detailed discussions took place over several weeks and both
companies used the data from the talks as a basis for the rapid negotiations
about this merger that started last Monday when Sir Richard Sykes,
Glaxo's chairman, met Jan Leschly, SB's chief executive, in New York.
The deal became possible following the departure of Lance last October.

Sykes and Leschly hammered out the broad outline of the deal between
Monday and Wednesday last week in secret, even though SB was still
negotiating a merger with AHP. Leschly telephoned Jack Stafford, AHP's
president, on Friday night to tell him SB was pulling out of the deal.

AHP is now said by analysts to be in play and many expected to find
another merger partner, such as Pharmacia & Upjohn, or to be bid for.

Under the terms of the deal, Glaxo will be the senior partner in the merger.
Its shareholders will take 59.5 per cent of the shares of the enlarged group,
while SB will take 40.5 per cent. Sykes will become executive chairman
with Leschly as chief executive.

Both Sir Peter Walters, SB's chairman, and Hugh Collum, the finance
director, are expected to leave, although they may be offered posts as
non-executive directors.

Union leaders reacted with shock to news of the deal and said they were
planning emergency meetings to discuss the implications. "It has all been
done in secret," said Roger Lyons, general secretary of the Manufacturing
Science and Finance Union.

Glaxo shares are expected to soar when the stockmarket opens tomorrow
morning, on forecasts that the merger could lead to a massive boost to the
group's earnings. But analysts also warned that the competition authorities
would look closely at the merger.

Among the areas the new group will be strongest in is anti-viral medicine
and some analysts predict the group will have to sell Famvir, SB's
anti-herpes drug, to meet anti-trust guidelines.

The enlarged group is also expected to review the SB portfolio of
consumer businesses since Sykes is committed to maintaining Glaxo as a
pure pharmaceutical business.

A series of SB's products, including Lucozade and Ribena soft drinks and
Aquafresh toothpaste could come up for sale.



To: CYBERKEN who wrote (14028)2/1/1998 8:58:00 PM
From: Henry Niman  Respond to of 32384
 
It looks like the FT has 5 or 6 articles in tomorrow's edition. Monday should be very exciting. Here's one:

SmithKline Beecham-Glaxo: Prescription for
the future

MONDAY FEBRUARY 2 1998

By Daniel Green

At 2 o'clock on Friday afternoon a telephone rang in an office high above
Franklin Plaza, central Philadelphia. The call was from Berkeley Square,
London.

The conversation was brief, but its effect will be felt for years. The man from
London simply said that the world's biggest corporate deal was on.

In Philadelphia was Jan Leschly, former Danish Man of the Year and Davis
Cup tennis star. A tall, lean, blond, his combative nature had taken him to the
chief executive's position at the UK's second biggest drugs company
SmithKline Beecham.

His caller was Sir Richard Sykes, an even leaner Yorkshire microbiologist
who had driven up through the drugs industry's ranks to be chairman of Glaxo
Wellcome, the UK number one.

Their deal was to create a company that would be worth more than œ100bn.
That would make it the biggest drugs company in the world and the third
biggest in the world after General Electric of the US and the oil group Royal
Dutch/Shell.

The two men had known each other for many years. In the 1980s, both
worked for US company Squibb, with Mr Leschly the senior of the two.

Although they were rivals running UK drugs companies headquartered in
West London, both men got on well, serving on the same industry committees.
Indeed, Mr Leschly seemed to be able to deal with Sir Richard's aggressive
style better than other pharmaceuticals executives.

The two had a similar strategic view as well - that the drugs sector was
destined to consolidate sooner or later. The two had held brief and
inconclusive merger talks early in 1997. But Glaxo was only two years out of
its hostile takeover of UK rival Wellcome and was not ready for another
upheaval.

The trigger for the resumption of talks was the revelation last weekend that
SmithKline was considering a merger with US rival American Home Products.

It galvanised Sir Richard into calling Mr Leschly to suggest there might be a
better deal on offer. The two agreed to meet.

On Tuesday, Mr Leschly and Sir Richard were talking face-to-face in New
York. Such was the secrecy that SmithKline staff were simultaneously
publishing official confirmation of AHP talks.

By Wednesday, a few senior executive were told of the plans so that discreet
preparations could be made for the massive task of telling the two companies'
110,000 employees of the merger.

On Thursday SmithKline's board met at its US headquarters in Philadelphia to
give the deal the nod.

On Friday Glaxo's board met at its Greenford site, west of London, with the
same result. At 7pm London time, Sir Richard made that call to Mr Leschly.

Not everyone in the industry is shocked by the news. Senior executives at
Novartis, the Swiss drugs company, see it as confirmation of the wisdom of
their 1996 decision to create the company out of former Basle rivals Ciba and
Sandoz.

The parallels between the two deals are striking. Ciba and Sandoz were
neighbours; SmithKline and Glaxo have headquarters a few miles from each
other in West London, and their main research centres are a few miles apart
to the north of the city.

Top management at both companies are well-acquainted and share a social
and industrial culture. Their view is that there is plenty more consolidation to
come in the fragmented sector.

A combination of Glaxo and SmithKline would have a global market share of
more than 8 per cent, far ahead of Novartis, and Merck at about 5 per cent.

So if the destiny of the industry is to consolidate, what better than to pluck up
the courage to find a willing partner, rather than risk being a wallflower at the
pharmaceuticals industry ball?

If Novartis is indeed the model for Glaxo SmithKline - as the company is
likely to be called - then about 10 per cent of the new company's 110,000
workforce can expect to lose their jobs over the next two to three years.
About 20 per cent went from Novartis in Switzerland.

Novartis cut staff largely through early retirement. That might not be so easy at
Glaxo, which has just emerged from the takeover of Wellcome in which 1,700
jobs went in the UK alone.

Not all drugs industry chiefs share Sir Richard and Mr Leschly's confidence in
merger.

Only last Thursday, Jean-Ren‚ Fourtou, chairman of France's
Rh“ne-Poulenc, warned that mergers would boost profits only for two years,
while costs were being cut.

After that, the new company would be thrown back once again on research
and development to create new products. Therein lies the drugs industry's long
term problem: R&D is not producing enough new products to sustain historic
levels of growth.

Indeed, work by Andersen Consulting last year suggested that productivity
needed to jump eightfold for the average company to grow at 10 per cent a
year. No wonder the drugs industry has signed thousands of partnership
agreements with biotechnology companies: they are effectively contracting out
an increasing slice of R&D.

Mr Fourtou's caution is not likely to dissuade chief executives across the
industry from re-examining their merger options, not least because the
biotechnology sector is an unproven way of boosting R&D productivity.

There have been large mergers and acquisitions every year since 1993. As
well as Glaxo and Novartis, American Home Products paid almost $10bn for
American Cyanamid; Merck and Eli Lilly of the US paid $6.3bn and $4bn
respectively for drug distributors; SmithKline paid $2.3bn for a distributor and
more than $4bn for Kodak's Sterling Health operation.

Last year was quieter. The $11bn takeover by Switzerland's Roche of the
privately held German company Boehringer Mannheim was the largest
transaction.

The 1980s had been different. Only in 1989 was there anything comparable:
Beecham of the UK merged with SmithKline Beckman of the US, and
Bristol-Myers merged with US rival Squibb.

The reasons for change lies in the economics of healthcare.

Drug company profits accelerated quickly in the 1980s as the advanced of
post-war science led to big-selling new products such as Glaxo's ulcer drug
Zantac.

In the 1990s healthcare became one of the biggest burdens to developed
countries. The US healthcare bill is about $1,000bn a year.

Bill Clinton came to power in 1992 promising to reform healthcare. This
coincided with the realisation that patents of important drugs such as Tagamet
and Zantac would start to expire in the 1990s.

Pharmaceuticals company share prices fell rapidly. For the first time in a
decade, share valuations assumed growth rates worse than the market
average.

The industry's response was mergers and acquisitions, although it remains to
be seen whether Mr Fourtou's reservations hold true and that cost-cutting and
product based growth are not linked.

Glaxo and SmithKine insist this merger is "not about cost-cutting". They
emphasise the combined R&D budget of almost œ2bn a year.

However, the counter argument against this has been put on more than one
occasion by Mr Leschly himself: doubling a company's size means that twice
the new product launches are needed to grow at a given rate, and there is no
evidence to suggest that a bigger R&D set-up is more efficient.

Perhaps more importantly, the marketing muscle of the two companies would
be combined. Drugs companies have recruited thousands of new sales
representatives in the US alone over the past two years and have shown
commercials for drugs on prime time television.

Sir Richard has admitted that there was a close correlation between sales of
the ulcer drug Zantac and the number of sales people assigned to selling it.
The constraint was one of resources.

The new emphasis on marketing, has helped the drugs industry's prospects, as
has the failure of health reform plans in the US and the modesty of efforts
elsewhere.

But the mergers and acquisitions culture has stayed: Glaxo made no significant
acquisitions from 1958 until 1995 when it made two.

Few companies these days - Merck is a rare exception - rule out the big deal
happening to them sooner or later.

Indeed, a pattern seems to be emerging. The deals that have worked best are
those between companies that are culturally and geographically close, such as
Novartis. Those that have had troubles were very different, such as Pharmacia
& Upjohn.

That means that crystal ball gazers should focus on Bayer, Hoechst and
Schering in Germany, Rh“ne-Poulenc, Sanofi and Synth‚labo in France, and
Zeneca in the UK.

In the US, the names to watch are ScheringPlough, American Home
Products, Bristol-Myers Squibb, Pfizer, Amgen, Abbott and several others.

These are companies either driven by ambition to be in the industry's top
half-dozen or fearful that they will be squashed by behemoths with
unstoppable research, development and marketing power.

The obstacles remain geography and the human factor: which chief executive
will run the show? SmithKline and Glaxo appear to have found a workable
answer - Sir Richard would be executive chairman, with Mr Leschly as chief
executive - as did Novartis. For others, such as Pharmacia & Upjohn,
Bristol-Myers and Squibb, and SmithKline and Beecham, serious problems
damaged the companies.

All the chief executives would rather be the one to make the telephone call
than to receive it. That call, it seems, is increasingly likely to come from the
competitor around the corner.



To: CYBERKEN who wrote (14028)2/2/1998 5:22:00 AM
From: Henry Niman  Respond to of 32384
 
Here's what the NY Times had to say this morning:

February 2, 1998

Huge Drug-Merger Proposal Sends
Industry Into Shock

Related Articles
Drug Makers Are Weighing Mega-Merger (Jan. 31)
Wave of Mergers Recasts the Face of Business (Jan. 19)

Forum
Join a Discussion on Merger Mania

By DAVID J. MORROW

he proposed merger of SmithKline PLC and Glaxo Wellcome PLC
is beginning to send a shock through the pharmaceutical industry.

The combined company, which would be formed in the largest corporate
merger ever, would have a stock-market capitalization of $166 billion
and would dwarf its competitors in worldwide pharmaceutical sales.

In virtually every category, the combination is huge. SmithKline and
Glaxo, which are already two of the world's largest drug companies,
would have $19 billion in worldwide pharmaceutical sales, according to
IMS America Ltd., which tracks industry statistics, some 40 percent
more than the No. 2 Merck & Co.'s $11.4 billion.

In an industry heavily dependent on research and development, Glaxo
and SmithKline would have a $3 billion annual budget, roughly $1 billion
more than Pfizer.

The proposed deal, which was announced on Friday night, has already
drawn opposition. A British labor union urged the British government on
Sunday to block the deal.

The Manufacturing, Science and Finance Union, which represents more
than 20,000 people employed by both companies, complained that the
merger could result in the loss of 10,000 jobs in Britain and severely
diminish the country's pool of skilled scientists.

A spokeswoman for SmithKline said the merger and its impact on
employment would be examined by regulators, but refused to say
anything more. Neither company would disclose how many employees
might lose their jobs in a merger. Analysts have predicted that 10 percent
of the companies' combined work force could lose their jobs.

Analysts also expect that regulators may question the market dominance
that SmithKline combined with Glaxo would have in some product
categories -- pain killers and ulcer medications, for example -- but they
otherwise expect the deal to pass.

One problem with SmithKline's proposed merger discussions with
American Home Products Corp., which the British company announced
had ended on Friday, were British regulators' concerns that one of their
largest companies might move to the United States. That was especially
alarming to some British institutional investors, some of whom are allowed
to invest only in companies headquartered in Britain.

While Britain's unions may have concerns over the merger, two of
Europe's top investment banks may reap record fees from the deal.
Analysts estimate that Lazard Brothers & Co., which is advising Glaxo
Wellcome, and Morgan Stanley, Dean Witter, Discover & Co.,
SmithKline's handler, could split some 100 million pounds, or $164
million, if the merger was successful.

If the merger does go through, a combined SmithKline-Glaxo may be
able to successfully challenge Merck at the United States' doctors' offices
and pharmacies. The envy of the industry, Merck can deploy its national
sales force and have a drug in virtually all of the nation's outlets within
days of receiving approval from the Food and Drug Administration.

"Glaxo Wellcome has been heavily sales-focused," said Myron Holubiak,
general manager of Plymouth Group, the consulting arm of IMS America.
"Some 29 percent of their U.S. employees are in the sales force,
compared to around 15 percent at Lilly. Glaxo and SmithKline will have
more sales people than Merck."

In an era of blockbuster drugs, marked by annual sales of $1 billion or
more, a SmithKline merger with Glaxo would enable the combined
company to dominate several product categories and reverse slides in
others. Glaxo's top drug, the anti-ulcerant Zantac, lost its patent in August
and its $1.7 billion peak sales in the United States have shrunk to some
$1.1 billion, according to IMS America.

Zantac remains one of Glaxo's best sellers, but other drugs are also
strong players. Imitrex, Glaxo's anti-migraine drug, had $710 million in
sales through November, according to IMS America. The company also
has several popular antiviral medications, including AZT for HIV, the
virus that causes AIDS, and Valtrex for herpes. The anti-viral drug
segment is projected to grow some $500 million in the United States
annually.

SmithKline's two biggest drugs are Paxil, an anti-depressant with $851
million in sales through November, and the antibiotic Augmentin, with
$707 million in sales, according to IMS America. The two drugs make up
43 percent of SmithKline's U.S. pharmaceutical sales for last year.

"Glaxo's merging with SmithKline will simply redefine the playing field
among the big pharmaceutical companies," said Mark Becker, a
European pharmaceuticals analyst with J.P. Morgan Securities Ltd. in
Boston. "To create another company this size, Merck would have to
merge with Pfizer."

The merger talks between Glaxo Wellcome and SmithKline Beecham
represent an abrupt turn of events. Historically, there has been little love
lost between the two companies since Beecham, as it was known at the
time, made a hostile bid for Glaxo in 1971.

The deal was eventually blocked by the British government on the
grounds that it would create a monopoly, but that was some 15 years
before the industry embarked on a series of megadeals.

A merger of Glaxo and SmithKline would also reunite the two top
executives of those companies. Sir Richard Sykes, the chairman of Glaxo
Wellcome, was the vice president of infectious and metabolic diseases at
Squibb at the same time that Jan Leschly, SmithKline's chief executive,
headed the company's commercial development division.

Sykes eventually left Squibb to head research at Glaxo, while Leschly
stayed through the company's merger with Bristol-Myers in 1989. Once
it was clear that Bristol-Myers executives had the inside track to the top
jobs at the merged company, Leschly quit to study philosophy at
Princeton.

Some analysts and drug-industry executives are curious about how well
Leschly and Sykes will get along if the merger is successful. The
proposed merger would make Leschly the chief executive and Sykes the
executive chairman.

While there was speculation that the two men did not like each other from
their Squibb days, executives within Bristol-Myers said that if there was
any animosity between the two, it was strictly personal, not professional.

"That's one thing executives from all drug companies should keep in
mind," said Becker, the Morgan analyst. "If one company is going to
court another, you never know who you might be working with, or for."

Executives who know both Sykes and Leschly are quick to point out
their differences. Sykes, 55, is a research zealot who is most comfortable
in a research lab. Sykes frequently oversees a drug's entry to the market
through all its stages. He usually arrives at his office before 7 a.m. and
works so hard that he has often been at the point of collapse.

Leschly, 57, is Danish and notoriously intense. A former world-class
tennis player, Leschly is fiercely competitive, especially with possible
corporate rivals. One troubling point in SmithKline's merger talks with
American Home Products was that Leschly was not willing to give up the
chief executive's title.