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Biotech / Medical : Univec (UNVC) -- Ignore unavailable to you. Want to Upgrade?


To: Courtney Willfore who wrote (132)2/3/1998 6:05:00 PM
From: r. peter Dale  Read Replies (1) | Respond to of 181
 
Your suggestion about order announcements would be consistent with all available evidence. (How 'bout those new preview and spell check functions. Those Dryer bros., ain't they somethin...)

Peter



To: Courtney Willfore who wrote (132)2/12/1998 10:06:00 PM
From: squetch  Read Replies (2) | Respond to of 181
 
Didn't want you to miss this paper CW
ncbi.nlm.nih.gov
Science 1998 Feb 6;279(5352):863-867

Impaired Locomotion and Dopamine Signaling in Retinoid Receptor
Mutant Mice.

Kr&ecedil;zel W, Ghyselinck N, Samad TA, Dup‚ V, Kastner P, Borrelli E, Chambon P

Institut de G‚n‚tique et de Biologie Mol‚culaire et Cellulaire, CNRS, INSERM, Universit‚
Louis Pasteur, CollŠge de France, Boite Postale 163, 67404 Illkirch Cedex, France.

[Record supplied by publisher]

In the adult mouse, single and compound null mutations in the genes for retinoic acid receptor beta and retinoid X receptors beta and gamma resulted in locomotor defects related to dysfunction of the mesolimbic dopamine signaling pathway. Expression of the D1 and D2 receptors for dopamine was reduced in the ventral striatum of mutant mice, and the response of double null mutant mice to cocaine, which affects dopamine signaling in the mesolimbic system, was blunted. Thus, retinoid receptors are involved in the regulation of brain functions, and retinoic acid signaling defects may contribute to pathologies such as Parkinson's disease and schizophrenia.

PMID: 9452386



To: Courtney Willfore who wrote (132)2/18/1998 10:44:00 AM
From: Henry Niman  Read Replies (1) | Respond to of 181
 
CW, It's interesting that you and peter have these "relatives" that conveniently make off line remarks that can be quoted as a means of hyping stocks that you happen to be interested in. Do these "relatives" also have aliases (or have their names been changed to protect the innocent)? By the way, I'm still interested in how your "father" is doing. You and "Peter" certainly seem to have quite a bit "in common".