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Biotech / Medical : Caprius(CAPR), Breast MRI(former ANMR/MAMO) -- Ignore unavailable to you. Want to Upgrade?

To: luis a. garcia who wrote (2458)	2/8/1998 7:32:00 PM
From: luis a. garcia	Respond to of 2615

Breast MR Imaging: Leading Cancer Treatment in the Next Century (Arkansa (Steve's machine due to ship this month)) Steven E. Harms, MD The diagnostic capabilities of breast MR imaging are outlined, along with potential applications of this new technology in clinical management algorithms. 1. Recent serial section mastectomy correlations reveal an approximately twofold increase in sensitivity and a threefold increase in specificity of RODEO (rotating delivery of excitation off resonance) breast MR imaging over those of mammography. 2. Specific patterns have been demonstrated with high-resolution RODEO images that can be used to accurately identify ductal carcinoma in situ (DCIS), determine the probability of an infiltrating component, and establish the extent of disease. 3. The Accurate depiction of disease extent by MR imaging can be used to optimize breast conservation treatment. 4. Since radiation therapy accounts for a substantial portion of the cost and morbidity associated with breast-conserving surgery, breast MR imaging may aid in the selection of patients likely to benefit from radiation therapy. 5. MR imaging is a highly accurate method for determining chemotherapeutic response and presence of residual disease following induction chemotherapy. 6. Interstitial hyperthermia and cryotherapy have been used as minimally invasive treatment of cancer. Pathologic correlations with RODEO breast MR imaging have demonstrated a high degree of accuracy in delineating tumor margins and determining extent of disease. (S.E.H. receives research support from Bracco Diagnostics; is a consultant to Nycomed, Berlex, and Advanced Magnetics; and is a software licensee with MRI Devices.) luis