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Strategies & Market Trends : 2026 TeoTwawKi ... 2032 Darkest Interregnum -- Ignore unavailable to you. Want to Upgrade?

To: maceng2 who wrote (181492)	12/15/2021 10:46:07 PM
From: Roads End	1 Recommendation Recommended By marcher Read Replies (5) \| Respond to of 218043

I'm just now winding down a case of Covid. I used Ivermectine, Hydroxychloroquine, Azithromycin, monoclonal antibodies (regeneron) and a steroid inhaler. Not sure if any one of those made a difference by themselves but would use them again except maybe the Ivermectin after reading this article. Tollovid looks like it might do a better job as explained. Ivermectin Fans Have a New Champion to Root For - 3CL Protease Inhibitor Tollovid

To: maceng2 who wrote (181492)	12/19/2021 6:42:26 PM
From: Pogeu Mahone	Respond to of 218043

Omicron may sideline two leading drugs against COVID-19 The delta variant still accounts for more than 95% of estimated U.S. cases, according to the Centers for Disease Control and Prevention. Edited by: AP WashingtonUpdated on: December 19, 2021 23:34 IST Follow us on Image Source : APOmicron variant may sideline two leading drugs against COVID-19 HIGHLIGHTSThe delta variant still accounts for more than 95% of estimated U.S. casesThe Omicron variant has now been identified in 89 countries As strained U.S. hospitals brace for a new surge of COVID-19 cases caused by the fast-spreading omicron variant, doctors are warning of yet another challenge: the two standard drugs they’ve used to fight infections are unlikely to work against the new strain. For more than a year antibody drugs from Regeneron and Eli Lilly have been the go-to treatments for early COVID-19, thanks to their ability to head off severe disease and keep patients out of the hospital. But both drugmakers recently warned that laboratory testing suggests their therapies will be much less potent against omicron, which contains dozens of mutations that make it harder for antibodies to attack the virus. And while the companies say they can quickly develop new omicron-targeting antibodies, those aren’t expected to launch for at least several months. A third antibody from British drugmaker GlaxoSmithKline appears to be the best positioned to fight omicron. But Glaxo’s drug is not widely available in the U.S., accounting for a small portion of the millions of doses purchased by the federal government and distributed to states. “I think there’s going to be a shortage,” said Dr. Jonathan Li, director of the Harvard/Brigham Virology Specialty Laboratory. “We’re down to one FDA-authorized monoclonal antibody” with omicron because of the reduced effectiveness of Regeneron and Lilly’s drugs. The delta variant still accounts for more than 95% of estimated U.S. cases, according to the Centers for Disease Control and Prevention. But agency leaders say omicron is spreading faster than any past variant and will become the dominant strain nationwide within weeks. Delivered by injection or infusion, antibodies are laboratory-made versions of human proteins that help the immune system fight off viruses and other infections. Glaxo’s drug, developed with Vir Biotechnology, was specifically formulated to bind to a part of the virus that is less likely to mutate, according to the companies. Early studies of laboratory-simulated omicron by the drugmakers and outside researchers show promising results. A spokeswoman for the U.S. Department of Health and Human Services said the agency stopped shipping the Glaxo drug late last month to “conserve supply” of the only antibody drug that is likely to be effective against omicron while delta is still dominant. HHS is now preparing to ship 55,000 doses of the drug, called sotrovimab, to state health departments, with the doses arriving as early as Tuesday. “Current supply of sotrovimab is limited, however, we expect it to grow to approximately 300,000 additional doses in January,” the spokeswoman said in a statement. Prior to the pause in shipments, Glaxo’s drug accounted for about 10% of the 1.8 million antibody doses distributed to state health officials between mid-September and late November, according to federal figures. The spokeswoman didn’t elaborate on how the government will decide on where to send the drug. Those decisions could be particularly complex in coming weeks if different parts of the country see varying levels of delta and omicron strains. Dr. James Cutrell said officials are likely to allocate Glaxo’s antibody based on federal surveillance data showing which variant is circulating where. “Once certain regions cross a percentage of omicron they’re likely to start distributing the product to those regions,” said Dr. Cutrell of the University of Texas Southwestern Medical Center. “That’s really going to be the treatment of choice once omicron becomes dominant.” London-based Glaxo says it is on track to produce 2 million doses by May, under contracts with the U.S., Canada, the U.K., Japan and several other countries. The company is working to add more manufacturing capacity next year.The loss of two leading antibody therapies puts even more focus on a pair of highly anticipated antiviral pills that U.S. regulators are expected to soon authorize. The drugs from Pfizer and Merck would be the first treatments Americans can take at home to head off severe disease. Pfizer’s drug in particular has shown a powerful effect, curbing hospitalizations and deaths by nearly 90% in high-risk patients. “If it’s rolled out effectively this has a real big potential,” to make up for antibody treatments, said Andrew Pekosz, a virologist at Johns Hopkins University. “That’s an immediate place where these antivirals could minimize the impact of omicron.” Still, initial supplies of both drugs are expected to be limited. The shrinking toolbox of treatments is a painful reminder that the virus still has the upper hand in the U.S., even with more than 200 million Americans fully vaccinated. Scientists around the world are racing to understand omicron, including whether it causes more or less severe disease and how easily it evades protection from prior infection, vaccination, and antibody drugs. “We’re certainly going to see hospitalizations rise,” Cutrell said. “If we have a lack of antibodies that’s certainly going to contribute to that many more patients needing to be in the hospital.” Also Reads I Omicron alert: UK reports 10,000 fresh Covid cases, highest daily surge so far 0 seconds of 18 minutes, 36 secondsVolume 25% Latest India News OMICRON VARIANT COVID 1

To: maceng2 who wrote (181492)	12/19/2021 9:26:07 PM
From: Pogeu Mahone	1 Recommendation Recommended By maceng2 Read Replies (1) \| Respond to of 218043

Pfizer COVID-19 pill may not see approval for 'months' despite 'impressive' data. "It's going to be months," Fauci explained. "If you look, it's a very complicated synthetic process to make the drug. It is not something that's simple." fox35orlando.com current #vaccines even with #boosters are insufficient to neutralize live #omicron virus. As expected, pseudoviruses most labs are using are overestimating vaccine potency Striking Antibody Evasion Manifested by the Omicron Variant of SARS-CoV-2 twitter.com biorxiv.org just announced that due to the prevalence of Omicron and its resistance to Monoclonal Antibodies they will no longer be providing them as treatment. We are literally back at the beginning. Without a single available early intervention. We knew this was coming!! twitter.com There is one Monoclonal Antibodies treatment that does work I think just approved but it is hard to get now, called Sotrovimab