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Strategies & Market Trends : 2026 TeoTwawKi ... 2032 Darkest Interregnum -- Ignore unavailable to you. Want to Upgrade?


To: Cogito Ergo Sum who wrote (184493)2/27/2022 12:02:39 PM
From: Pogeu Mahone2 Recommendations

Recommended By
Ben Smith
maceng2

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When Hoffmann-La Roche wanted to give Leo a $60,000 bonus for Valium,

he refused it saying he wanted his children to earn their own money.

Valium synthesized 1959

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Leo Sternbach



Leo Sternbach, the medicinal chemist who soothed the anxieties of a generation of Americans with the invention of Librium and Valium, died Wednesday at his home in Chapel Hill, N.C. He was 97.Oct 1, 2005

Leo Sternbach, 97; Invented Valium, Many Other Drugs - Los ...

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While working for Hoffmann-La Roche in Nutley, New Jersey, Sternbach did significant work on new drugs. He is credited with the discovery of chlordiazepoxide (Librium), diazepam (Valium), flurazepam (Dalmane), nitrazepam (Mogadon), flunitrazepam (Rohypnol), clonazepam (Klonopin), and trimethaphan (Arfonad). Librium, based on the R0 6-690 compound discovered by Sternbach in 1956, was approved for use in 1960. In 1963, its improved version, Valium, was released and became astonishingly popular: between 1969 and 1982, it was the most prescribed drug in America, with over 2.3 billion doses sold in its peak year of 1978. With Moses Wolf Goldberg, Sternbach also developed "the first commercially applicable" method for synthesizing biotin. [6]

Sternbach held 241 patents, and his discoveries helped to turn Roche into a pharmaceutical industry giant. He did not become wealthy from his discoveries, but he was happy; he treated chemistry as a passion and said, "I always did just what I wanted to do". He was active in his career until the age of 95. Sternbach was a longtime resident of Upper Montclair, New Jersey, from 1943 to 2003. He then moved to Chapel Hill, North Carolina, where he died in 2005. [7] [8]