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Biotech / Medical : VVUS: VIVUS INC. (NASDAQ) -- Ignore unavailable to you. Want to Upgrade?

To: Zebra 365 who wrote (5373)	2/9/1998 10:56:00 PM
From: Zebra 365	Read Replies (4) \| Respond to of 23519

We made the Ladies Home Journal !! Some may recall, (Linda K. quoted me) that I said about a month ago that VVUS ads need to be in Ladies Home Journal for real effect. But I actually figured that we would probably get a play in one of the "Medical articles" in LHJ, I was right. March 1998 issue, page 17 "MY HUSBAND IS IMPOTENT" under, I believe, a recurring column entitled "Can This Marriage be Saved?" At the end three treatments are discussed, Caverject, the vacuum pump and MUSE, by name. Also, On the horizon, pills to take an hour before sex. Only one flaw, they implied that MUSE was also "on the horizon" with the "pills". Believe me this can have more impact on sales than the WSJ ads. No name was given for the "pills" Zebra

To: Zebra 365 who wrote (5373)	2/11/1998 12:05:00 AM
From: Tunica Albuginea	Read Replies (1) \| Respond to of 23519

Zebra,thanx, for the short info.Here is from the "other Vivus" thread: Message 3397794 ***************** To: +BigKNY3 (64 ) From: +Tunica Albuginea Tuesday, Feb 10 1998 11:55PM EST Reply # of 69 BigKNY3, here is the reference you requested. It is more authoritative than your source.The reason why doctors have a hard time evaluating the true efficacy of drugs is because of the blue smoke and mirrors emanating from the PR Depts of most Drug Cos and the uninformed support they get from lay people, including those with MBAs or PhDs but not MD degrees.This is why also we have the other big scam: the health food industry, but that is another issue.This data was previously posted by me and this posting would not have been necessary if you had taken the time to read them ( or at least the original textbook ).Somewhere along the line you need to explain the " blue halo " effect of Viagra on patients ( you haven't so far ). PS Don't spend too much time trying to convince DrDale Russell in your lonesome corner of all this mumbojumbo on PDE selectivity. DrRussell knows better than that. Maybe you should read his preface to this thread. TA ============================================================= From GOODMAN & GILLMAN'S THE PHARMACOLOGICAL BASIS OF THERAPEUTICS NINTH EDITION, 1997 ( The no 1 , US Medical School, Textbook of Pharmacology ) I abstracted in quotation, verbatim, the specific answer to your questions; I capitalized important points. ********************* Chapter 34 Page 833 . " MANY organs, including cardiac muscle, contain members OF ALL KNOWN PDE isoenzyme families (Bode et al., 1991: Nicholson et al., 1991)." "The SPECIFICITY of the "selective" inhibitors noted in Table 34-8 is RESTRICTED for most PDE isoenzymes to a RELATIVELY NARROW concentration range, with NON-SPECIFIC INHIBITION evident at HIGHER concentrations. " (tab;e 34-8 is from Nickolson 1991, summarized as follows: PDE-I: CNS modulation PDE-III: Positive inotropism PDE- IV: Airway smooth muscle relaxation PDE- V: Penile erection PDE-VI: Photoreceptor PDE-VII: Skeletal muscle "In addition, MOST of these inhibitors have OTHER known pharmacoloaical activities ' ****************** The original posts for the above:: - phosphodiesterase ( PDE ) sideffects - PDE ):Taken from Goodman & Gillman 1996 ED.Textbook of pharmacology. www3.techstocks.com - www3.techstocks.com TA