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Biotech / Medical : Agouron Pharmaceuticals (AGPH) -- Ignore unavailable to you. Want to Upgrade?

To: Zirdu who wrote (3794)	2/10/1998 2:22:00 PM
From: tommysdad	Read Replies (1) \| Respond to of 6136

<<Maybe, because of it's small molecular size and less "extraneous" material, for example, the "Crix belly" and "buffalo hump" problems will not be a side effect of Viracept, or maybe it will cause less severe effects.>> Huh? Crixivan is C36H47N5O4-H2O4S. Viracept is C32H45N3O4S-CH4O3S. Not a big diffrence in "molecular size" there. Neither is a particularly small molecule -- that term is usually reserved for molecules with molecular weights less than 400-500, and both Viracept and Crixivan beat that by a lot. There is nothing about the molecular structure of these molecules that would have anticipated this problem. It is certainly safe to assume that the "buffalo hump" effect will be different for the various PI's, but that difference will have to come from empirical observations in the clinic rather than guesses from molecular structure. Just curious: what part of either molecule do you consider to be "extraneous"?

To: Zirdu who wrote (3794)	2/10/1998 8:03:00 PM
From: Oliver & Co	Respond to of 6136

Ahahh! Diagnosed my first "Cryx Belly" today. A woman with full blown AIDS, who has been doing pretty well on triple Rx, increasing CD4, who has reactivated CMV retinitis. However, she has been putting on a lot of weight, getting a very "fat" belly. Increasing lipids, and GGTP. Liver, GB , Pancreas US done last week because of the increasing LFTs,only show "Fatty Liver". She is on Cryx, Zerit and Epivir (had allergy to Viracept). This type of fat is different than the one in my other patients. Also, she has no "Buffalo Hump". By the way, when she came to me a year ago from UM, she was dying.