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To: 5,17,37,5,101,... who wrote (518)	2/11/1998 11:34:00 PM
From: flickerful	Respond to of 756

unflappable. wouldn't you love to have seen that cigar explode looney tunes style ? thanks jackson, off to read the vanity piece. randy

To: 5,17,37,5,101,... who wrote (518)	2/11/1998 11:56:00 PM
From: flickerful	Respond to of 756

oh brother. that was an exercise... anyway, jackson, i am glad you showed your welcome smile here again. regards, randy

To: 5,17,37,5,101,... who wrote (518)	2/12/1998 4:25:00 AM
From: flickerful	Read Replies (1) \| Respond to of 756

for old time's sake: Taxol May Fight Kidney Disease as Well as Cancer Copyright c 1994-1996, The Trustees of the University of Pennsylvania ------------------------------------------------------------------------ Taxol, approved by the FDA for treatment of ovarian and breast cancer, may also be an effective medication for treatment of polycystic kidney diseases, as was recently published by David D.L. Woo et al. [Nature 368: 750(1994)]. Polycystic kidney diseases are the most common hereditary diseases of the human kidney and account for 10% of all kidney transplant or dialysis patients. There is currently no treatment for the formation and enlargement of renal cysts. Woo et al. developed an in vitro model of spontaneous cyst formation and found that taxol inhibits the process. Mice with polycystic kidney disease normally die of uremia (toxic levels of was products in their bloodstream) by 4-5 weeks of age. Similar mice treated weekly with taxol are still alive after 200 days. This "suggests that taxol or its analogs may be useful in the treatment of human polycystic kidney diseases," the researcher said. Because taxol acts on microtubules (large cytoskeletal filaments), "our data implicate the microtubule network in the genesis of polycystic kidney disease cysts in both in vitro and in vivo." ------------------------------------------------------------------------ OncoLink Home Page Disclaimer Please send comments on the OncoLink "Cancer News" Resource to: onco-news@oncolink.upenn.edu