Speaking of Ligand's future, here's an interesting patent that issued earlier this month (Jim Darnell is a LGND consultant and in 1992 LGND licensed the STAT (Signal Transducers and Activators of Transcription) technology from the Rockefeller):
United States Patent
5,716,622
Darnell, Jr., et. al.
Feb. 10, 1998
Functionally active regions of signal transducer and activators of transcription
Inventors:
Darnell, Jr.; James E. (Larchmont, NY); Wen; Zilong (New York, NY);
Horvath; Curt M. (New York, NY); Zhong; Zhong (New York, NY).
Assignee:
The Rockefeller University (New York, NY).
Appl. No.:
369,796
Filed:
Jan. 6, 1995
Intl. Cl. :
A61K 39/385, C07K 14/715, C07K 17/02
Current U.S. Cl.:
424/185.1; 424/193.1; 530/350; 530/403
Field of Search:
530/350, 403; 424/185.1, 193.1
References Cited | [Referenced By]
Foreign Patent Documents
WO 93/19179
Sept., 1993
WO
Other References
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Primary Examiner: Chan; Christina
Assistant Examiner: VanderVegt; F. Pierre
Attorney, Agent or Firm: Klauber & Jackson
Abstract
The present invention relates generally to intracellular receptor recognition proteins or factors,
termed Signal Transducers and Activators of Transcription (STAT), to methods and compositions
utilizing such factors, and to the antibodies reactive toward them, in assays and for diagnosing,
preventing and/or treating cellular debilitation, derangement or dysfunction. More particularly, the
present invention relates to particular functional domains of molecules that exhibit both receptor
recognition and message delivery via DNA binding in receptor-ligand specific manner, i.e., that
directly participate both in the interaction with the ligand-bound receptor at the cell surface and in
the activity of transcription in the nucleus as a DNA binding protein. The invention likewise relates to
the antibodies and other entities that are specific to the functional domain of a STAT protein and that
would thereby selectively modulate its activity.
16 Claims, 31 Drawing Figures
The research leading to the present invention was supported by National Institute of Health Grant
Nos. AI34420 and AI32489. Accordingly, the Government may have certain rights in the invention. |
