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To: Stock Puppy who wrote (39063)1/18/2025 11:46:12 AM
From: Stan1 Recommendation

Recommended By
Stock Puppy

  Respond to of 39305
 
This is an interesting discussion.



To: Stock Puppy who wrote (39063)1/18/2025 2:31:04 PM
From: Stock Puppy1 Recommendation

Recommended By
Thomas M.

  Respond to of 39305
 
Another interesting tidbit about DMSO:

PPE such as nitrile or latex gloves are permeable to DMSO -
SOP for a researcher handling a compound dissolved in DMSO - if any gets on the glove, stop everything and remove the glove ASAP. It's just a few seconds before it begins going through the glove and onto skin. The longer the glove is on, the larger the exposure/dose.
And any toxins on the glove...
if it's not seen, then the researcher knows some went on the glove - DMSO on the skin quickly causes a unique taste in your mouth - so the researcher knows there is a problem and can limit exposure by removing gloves as soon as the taste appears.



To: Stock Puppy who wrote (39063)1/18/2025 4:47:14 PM
From: russet1 Recommendation

Recommended By
Stock Puppy

  Respond to of 39305
 
This is taking me back a couple of decades but the exact molecule weights could probably be found in a search starting with the documents below. Some studies were done by a company called Dimethaid. They were using the Diclofenac NSAID and DMSO to treat arthritic bones. From memory, virus's, proteins and DNA were not absorbed, by I am not sure of the sizes.



Dimethyl sulfoxide: an effective penetration enhancer for topical administration of NSAIDs

Karrie Marren 1

Affiliations Expand


Abstract
Dimethyl sulfoxide (DMSO) is a molecule with a long history in pharmaceutics and is now well established as a penetration enhancer in topical pharmaceutical formulations. It is currently used for this purpose in diclofenac sodium topical solution (approved in the United States to treat signs and symptoms of osteoarthritis) and idoxuridine topical solution (approved in Europe for the treatment of herpes zoster). This article reviews the mechanism of action of DMSO as a pharmaceutical penetration enhancer, the characteristics of the molecule that facilitate transdermal drug delivery, and studies of efficacy and safety. The clinical use of pharmaceutical-grade DMSO as a penetration enhancer is supported by the robust data that have accumulated over the past 3 decades demonstrating the favorable safety and tolerability profile. Dimethyl sulfoxide is a safe and effective mechanism for facilitating the transdermal delivery of both hydrophilic and lipophilic medications to provide localized drug delivery.

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Publication types

  • Research Support, Non-U.S. Gov't


  • Review


MeSH terms

  • Administration, Topical


  • Anti-Inflammatory Agents, Non-Steroidal / administration & dosage*


  • Dimethyl Sulfoxide / administration & dosage*


  • Drug Delivery Systems


  • Drug Synergism


  • Herpes Zoster / drug therapy*


  • Humans


  • Osteoarthritis / drug therapy*


  • Skin Absorption


  • Solvents / administration & dosage*


Substances

  • Anti-Inflammatory Agents, Non-Steroidal


  • Solvents


  • Dimethyl Sulfoxide


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