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To: Les H who wrote (47897)	9/22/2025 5:56:33 PM
From: Les H	Read Replies (1) \| Respond to of 48927

What the research says about autism and Tylenol use during pregnancy3 Essential Questions with Dr. Zeyan Liew, Associate Professor of Epidemiology (Environmental Health Sciences); Yale Center for Perinatal, Pediatric, and Environmental Epidemiology By Colin Poitras September 22, 2025 Does acetaminophen (Tylenol) use during pregnancy cause autism?? Dr. Zeyan Liew: We do not know yet for sure whether Tylenol causes autism. Indeed, there have been multiple observational studies conducted across different populations that show associations between frequent use of Tylenol in pregnancy and some negative effects on a child’s neurodevelopment. However, not all studies are specific about autism. Further, whether other possible factors related to Tylenol use are driving these associations needs to be thoroughly evaluated. Are there alternative pain relievers that women can use during pregnancy?? ZL: Unfortunately, there is no equivalent alternative for Tylenol at the moment, as other over-the-counter pain medications, such as ibuprofen, are recommended to be avoided during pregnancy, especially after 20 weeks of gestation. It is important that people understand our knowledge in this area is constantly evolving. While acetaminophen is currently recommended by regulatory and clinical agencies as safe to use in pregnancy, we need to convey the possibility that these guidelines may be challenged if new and stronger research data emerge that suggest potential?risks during pregnancy and child development. These are nuances in medication safety communication. We do not want people to fear using a treatment—but we also need to be mindful about limiting potential harm and risks. In this case, frequent and prolonged use of Tylenol during pregnancy is a potential risk. That said, untreated maternal fever or pain can pose risks to pregnancy and child development. Thus, it is recommended that pregnant women consult with their health care providers and, if pain relief is necessary, that they use the lowest effective dose and duration for Tylenol to alleviate these conditions. ysph.yale.edu The last sentence contains the current guidance for using Tylenol during pregnancy as seen in the conclusions sections of the studies.