To: maceng2 who wrote (1562951 ) 10/5/2025 12:01:41 AM From: Wharf Rat 2 RecommendationsRecommended By Eric rdkflorida2
Read Replies (1) | Respond to of 1576329 "While most people realise that the Human Race somehow got along for a while without mRNA vaccines" We got along without a lot of things, including disinformation spread over the internet. == "the worst incidence of adverse reactions ever" AI Overview The Cutter Incident of 1955 is widely considered the worst incidence of adverse vaccine reactions in history. Due to a manufacturing error, a batch of polio vaccines contained live poliovirus instead of inactivated virus, leading to approximately 40,000 non-paralytic cases, 56 paralytic cases, and five deaths among vaccinated children. The Cutter Incident (1955)The error: After the Salk polio vaccine was licensed for widespread use, a batch produced by Cutter Laboratories in California was improperly inactivated, meaning it still contained live poliovirus.The outcome: The contaminated vaccines were administered to approximately 120,000 children. As a result, 40,000 developed "abortive" polio (a non-paralytic form of the disease), 56 were paralyzed, and five children died. Some of the vaccinated children also transmitted the virus, causing additional cases.The impact: This tragedy severely damaged public trust in the new polio vaccine. However, it also led to significant improvements in vaccine manufacturing standards and federal oversight through the Food and Drug Administration (FDA), preventing similar disasters in the future. Other notable historical vaccine incidents While the Cutter Incident is the most famous for its scale and severity, other historical incidents involving contaminated or improperly made vaccines also caused serious adverse events:Tetanus contamination (1901): In separate incidents, batches of diphtheria antitoxin and smallpox vaccine were contaminated with tetanus. This resulted in the deaths of 13 children in St. Louis, Missouri, and nine children in Camden, New Jersey. These events spurred the creation of the 1902 Biologics Control Act, the precursor to modern vaccine regulation.Swine flu vaccine and GBS (1976): Following a 1976 swine flu vaccination campaign in the US, an increased risk of Guillain-Barré Syndrome (GBS)—a rare neurological disorder—was observed. The vaccination program was halted, but a subsequent review concluded that the risk was small, at about one extra GBS case for every 100,000 people vaccinated.RotaShield and intussusception (1999): The first licensed rotavirus vaccine, RotaShield, was withdrawn from the market after it was linked to an increased risk of intussusception, a type of bowel obstruction, in infants. A safer vaccine was later developed and introduced.Fatal vaccination error in Samoa (2018): A deadly error occurred in Samoa where two children died after receiving an MMR vaccine that was improperly prepared with an expired muscle relaxant instead of the correct diluent. The accident led to a steep decline in vaccine confidence and a subsequent measles epidemic that killed dozens of children. Adverse reactions today Modern vaccines are subject to far more stringent manufacturing standards and safety protocols. As a result, serious adverse reactions are extremely rare. For example, a severe allergic reaction like anaphylaxis occurs in only about 1 to 2 people per million doses administered. Continued monitoring by agencies like the Centers for Disease Control and Prevention (CDC) and the FDA ensures that any rare safety concerns are quickly identified and addressed.