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Non-Tech : Enamelon (ENML) - Does anyone follow this? -- Ignore unavailable to you. Want to Upgrade?

To: Dr. Seuss who wrote (456)	3/3/1998 8:00:00 PM
From: chester lee	Respond to of 863

Dr Seuss, This is the first I've heard of this rumor. I've actually heard rumors (on AOL boards) that ENML is effective against sensitive teeth, rendering the teeth less sensitive after use. If this rumor proves out over time (and from their clinical trials), then I say... SO WHAT. I use to have sensitive teeth, as did my father. He used Sensodyne and that have helped him. He has had sensitive teeth for over twenty years, so using Sensodyne helps him, but does NOT completely take away teh sensitivity. Sensodyne, by the way, has data and scientific proof on why their product works. I will go no further, since I know everyone is familiar to Sensodyne. In my case, I went to my dentist (who also happens to be my sister), and she gave me a flouride rinse to use 2X a day after brushing. After using about 4 oz of the rinse slution, my sensitive teeth are no longer sensitive to hot or cold. My point: There are already effective treatments for sensitive teeth. If ENML's product also help improve someone's sensitivity to hot or cold, then they have another "me too" product. If it turns out that your rumor is correct, and that ENML causes teeth to turn grey, then look out below because no one wants grey looking teeth. Chester P.S. Wasn't the anniversary of the first Dr Suess book Yesterday??

To: Dr. Seuss who wrote (456)	3/4/1998 8:12:00 AM
From: Greg B.	Respond to of 863

Dr. Seuss, First I heard of this rumor. Heard other rumors, but they seem groundless, like teeth falling out. This sounds like another one, because no one in my "study group" reported an increase in sensitivity with heat and cold. They noticed a reduction in sensitivity - not an increase. As for teeth coloration, there was no noticeable difference. As for a cover up, that seems very unlikely. When P&G present their findings on Friday, any color changing phenomenon should also be reported. This "story" is not containable if it were true, don't you think? Your source should not fear being identified, or tagged a whistle blower. For others can confirm the story. (Unlike the situation at the Oral office.) Greg

To: Dr. Seuss who wrote (456)	3/4/1998 12:25:00 PM
From: matthew lamberson	Respond to of 863

I HAVE BEEN USING IT FOR SOME TIME NOW AND HAD THE EXACT OPPOSITE EFFECTS.

To: Dr. Seuss who wrote (456)	3/4/1998 1:53:00 PM
From: Greg B.	Respond to of 863

Dr. Seuss, There's nothing like a good rumor. So I spoke with two sources, each on the know of both sides of the battlefield. I'm staying out of the politics, except to mention: First, this "rumor" is just in fact that. No wonder why your source wants to remain anonymous. Second, P&G is concerned about ENML, especially in light with Colgate's differentiation with triclosan. Third, the P&G studies comparing Enamelon are already being questioned. These are the rat model testing and reminearlization/acid resistance findings. BTW, Just found out that there are 6 ENML papers (not 5 studies - add 1126 to the list). That makes 10 studies in total (including 4 peer reviewed from last years meeting). Fourth, for the sensitive teeth argument, one of the studies showed that there was a 20% reduction in the number of sensitive teeth; while with control toothpaste showed no change (actually an increase in sensitivity, but nothing can be drawn from that). Guess who was the control? Fiifth, there are 5 large scale clinical studies underway as part of FDA approval process. However, in the meantime, ENML is in compliance with monograph. So far, the FDA has not challenged ENML, nor has requested review of the battery of tests required to keep on file. (This info continues to be consistent with info solicited from FDA earlier.) Anyhow, I'm going to sit back and watch the toothpaste wars escalate. But be careful of those rumors. They can come back to haunt you! Nevertheless, I still want to hear them. At least they are great for a laugh. Greg